RESUMO
In recent years it has been reported that the chemotherapeutic CYVADIC regime has contributed well to the treatment of advanced soft tissue sarcomas. We treated a patient with a large gastric epithelioid leiomyosarcoma with a combination of surgery and the CYVADIC regime. We believe that our result warrants further investigation in this field.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Leiomiossarcoma/terapia , Neoplasias Gástricas/terapia , Terapia Combinada , Ciclofosfamida/administração & dosagem , Dacarbazina/administração & dosagem , Doxorrubicina/administração & dosagem , Humanos , Leiomiossarcoma/tratamento farmacológico , Leiomiossarcoma/patologia , Leiomiossarcoma/cirurgia , Masculino , Pessoa de Meia-Idade , Fatores Sexuais , Neoplasias Gástricas/tratamento farmacológico , Neoplasias Gástricas/patologia , Neoplasias Gástricas/cirurgia , Vincristina/administração & dosagemAssuntos
Gangrena/patologia , Doenças do Pênis/patologia , Escroto/patologia , Adulto , Infecções Bacterianas/patologia , Infecções Bacterianas/terapia , Gangrena/microbiologia , Gangrena/terapia , Humanos , Masculino , Doenças do Pênis/microbiologia , Doenças do Pênis/terapia , Fenômeno de Shwartzman/patologiaAssuntos
Injúria Renal Aguda/induzido quimicamente , Cefaloridina/efeitos adversos , Adulto , Idoso , Feminino , Humanos , MasculinoRESUMO
The elimination of ciprofloxacin from serum was studied in 16 patients (10 F, 6M, age 44-70 years) with end stage renal disease, treated with haemodialysis. The dosage of ciprofloxacin was 200 mg i.v. given by bolus injection (10 patients) or 250 mg orally (6 patients) on a day without and a day with dialysis (8 hours before dialysis was started). Samples were taken at regular intervals from the arteriovenous shunt and from venous peripheral blood. Concentrations of ciprofloxacin were measured by a biological assay. The mean peak serum levels after 200 mg i.v. were 3.5 mg/l measured 0.5 hour after the gift. After an oral dose of 250 mg the mean peak serum level measured one hour after the gift amounted to 1.5 mg/l. The serum half life was 8.5 h without dialysis and 5.5 h with dialysis. It was calculated from AUC values during dialysis that about 15% of the drug was eliminated by the artificial kidney.