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J Infect Dis
; 225(10): 1861-1864, 2022 05 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34971376
RESUMO
A safe and effective vaccine against multidrug-resistant gonorrhea is urgently needed. An experimental peptide vaccine called TMCP2 that mimics an oligosaccharide epitope in gonococcal lipooligosaccharide, when adjuvanted with glucopyranosyl lipid adjuvant-stable emulsion, elicits bactericidal immunoglobulin G and hastens clearance of gonococci in the mouse vaginal colonization model. In this study, we show that efficacy of TMCP2 requires an intact terminal complement pathway, evidenced by loss of activity in C9-/- mice or when C7 function was blocked. In conclusion, TMCP2 vaccine efficacy in the mouse vagina requires membrane attack complex. Serum bactericidal activity may serve as a correlate of protection for TMCP2.
Assuntos
Gonorreia , Neisseria gonorrhoeae , Animais , Vacinas Bacterianas , Proteínas do Sistema Complemento , Modelos Animais de Doenças , Feminino , Gonorreia/prevenção & controle , Lipopolissacarídeos , Camundongos
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