AI model for predicting adult cochlear implant candidacy using routine behavioral audiometry.

OBJECTIVE: To describe an AI model to facilitate adult cochlear implant candidacy prediction based on basic demographical data and standard behavioral audiometry. METHODS: A machine-learning approach using retrospective demographic and audiometric data to predict candidacy CNC word scores and AzBio sentence in quiet scores was performed at a tertiary academic center. Data for the model were derived from adults completing cochlear implant candidacy testing between January 2011 and March 2023. Comparison of the prediction model to other published prediction tools and benchmarks was performed. RESULTS: The final dataset included 770 adults, encompassing 1045 AzBio entries, and 1373 CNC entries. Isophoneme scores and word recognition scores exhibited strongest importance to both the CNC and AzBio prediction models, followed by standard pure tone average and low-frequency pure tone average. The mean absolute difference between the predicted and actual score was 15 percentage points for AzBio sentences in quiet and 13 percentage points for CNC word scores, approximating anticipated test-retest constraints inherent to the variables incorporated into the model. Our final combined model achieved an accuracy of 87 % (sensitivity: 90 %; precision: 80 %). CONCLUSION: We present an adaptive AI model that predicts adult cochlear implant candidacy based on routine behavioral audiometric and basic demographical data. Implementation efforts include a public-facing online prediction tool and accompanying smartphone program, an embedded notification flag in the electronic medical record to alert providers of potential candidates, and a program to retrospectively engage past patients who may be eligible for cochlear implantation based on audiogram results.

Transparent exopolymer particles: from aquatic environments and engineered systems to membrane biofouling.

Transparent exopolymer particles (TEP) are ubiquitous in marine and freshwater environments. For the past two decades, the distribution and ecological roles of these polysaccharide microgels in aquatic systems were extensively investigated. More recent studies have implicated TEP as an active agent in biofilm formation and membrane fouling. Since biofouling is one of the main hurdles for efficient operation of membrane-based technologies, there is a heightened interest in understanding the role of TEP in engineered water systems. In this review, we describe relevant TEP terminologies while critically discussing TEP biological origin, biochemical and physical characteristics, and occurrence and distributions in aquatic systems. Moreover, we examine the contribution of TEP to biofouling of various membrane technologies used in the desalination and water/wastewater treatment industry. Emphasis is given to the link between TEP physicochemical and biological properties and the underlying biofouling mechanisms. We highlight that thorough understanding of TEP dynamics in feedwater sources, pretreatment challenges, and biofouling mechanisms will lead to better management of fouling/biofouling in membrane technologies.

Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers: Results of a Longitudinal Cohort.

OBJECTIVE: The aim of the study is to evaluate COVID-19 risk factors among healthcare workers (HCWs) before vaccine-induced immunity. METHODS: We conducted a longitudinal cohort study of HCWs ( N = 1233) with SARS-CoV-2 immunoglobulin G quantification by ELISA and repeated surveys over 9 months. Risk factors were assessed by multivariable-adjusted logistic regression and Cox proportional hazards models. RESULTS: SARS-CoV-2 immunoglobulin G was associated with work in internal medicine (odds ratio [OR], 2.77; 95% confidence interval [CI], 1.05-8.26) and role of physician-in-training (OR, 2.55; 95% CI, 1.08-6.43), including interns (OR, 4.22; 95% CI, 1.20-14.00) and resident physicians (OR, 3.14; 95% CI, 1.24-8.33). Odds were lower among staff confident in N95 use (OR, 0.55; 95% CI, 0.31-0.96) and decreased over the follow-up. CONCLUSIONS: Excess COVID-19 risk observed among physicians-in-training early in the COVID-19 pandemic was reduced with improved occupational health interventions before vaccinations.

Development and Application of a Polydimethylsiloxane-Based Passive Air Sampler to Assess Personal Exposure to SARS-CoV-2.

Exhaled respiratory droplets and aerosols can carry infectious viruses and are an important mode of transmission for COVID-19. Recent studies have been successful in detecting airborne SARS-CoV-2 RNA in indoor settings using active sampling methods. The cost, size, and maintenance of these samplers, however, limit their long-term monitoring ability in high-risk transmission areas. As an alternative, passive samplers can be small, lightweight, and inexpensive and do not require electrical power or maintenance for continual operation. Integration of passive samplers into wearable designs can be used to better understand personal exposure to the respiratory virus. This study evaluated the use of a polydimethylsiloxane (PDMS)-based passive sampler to assess personal exposure to aerosol and droplet SARS-CoV-2. The rate of uptake of virus-laden aerosol on PDMS was determined in lab-based rotating drum experiments to estimate time-weighted averaged airborne viral concentrations from passive sampler viral loading. The passive sampler was then embedded in a wearable clip design and distributed to community members across Connecticut to surveil personal SARS-CoV-2 exposure. The virus was detected on clips worn by five of the 62 participants (8%) with personal exposure ranging from 4 to 112 copies of SARS-CoV-2 RNA/m3, predominantly in indoor restaurant settings. Our findings demonstrate that PDMS-based passive samplers may serve as a useful exposure assessment tool for airborne viral exposure in real-world high-risk settings and provide avenues for early detection of potential cases and guidance on site-specific infection control protocols that preempt community transmission.

Bots' Activity on COVID-19 Pro and Anti-Vaccination Networks: Analysis of Spanish-Written Messages on Twitter.

This study aims to analyze the role of bots in the dissemination of health information, both in favor of and opposing vaccination against COVID-19. Study design: An observational, retrospective, time-limited study was proposed, in which activity on the social network Twitter was analyzed. Methods: Data related to pro-vaccination and anti-vaccination networks were compiled from 24 December 2020 to 30 April 2021 and analyzed using the software NodeXL and Botometer. The analyzed tweets were written in Spanish, including keywords that allow identifying the message and focusing on bots' activity and their influence on both networks. Results: In the pro-vaccination network, 404 bots were found (14.31% of the total number of users), located mainly in Chile (37.87%) and Spain (14.36%). The anti-vaccination network bots represented 16.19% of the total users and were mainly located in Spain (8.09%) and Argentina (6.25%). The pro-vaccination bots generated greater impact than bots in the anti-vaccination network (p < 0.000). With respect to the bots' influence, the pro-vaccination network did have a significant influence compared to the activity of human users (p < 0.000). Conclusions: This study provides information on bots' activity in pro- and anti-vaccination networks in Spanish, within the context of the COVID-19 pandemic on Twitter. It is found that bots in the pro-vaccination network influence the dissemination of the pro-vaccination message, as opposed to those in the anti-vaccination network. We consider that this information could provide guidance on how to enhance the dissemination of public health campaigns, but also to combat the spread of health misinformation on social media.

Non-monotonic dependence of water reorientation dynamics on surface hydrophilicity: competing effects of the hydration structure and hydrogen-bond strength.

The reorientation dynamics of interfacial water molecules was recently shown to change non-monotonically next to surfaces of increasing hydrophilicity, with slower dynamics next to strongly hydrophobic (apolar) and very hydrophilic surfaces, and faster dynamics next to surfaces of intermediate hydrophilicities. Through a combination of molecular dynamics simulations and analytic modeling, we provide a molecular interpretation of this behavior. We show that this non-monotonic dependence arises from two competing effects induced by the increasing surface hydrophilicity: first a change in the hydration structure with an enhanced population of water OH bonds pointing toward the surface and second a strengthening of the water-surface interaction energy. The extended jump model, including the effects due to transition-state excluded volume and transition-state hydrogen-bond strength, provides a quasi-quantitative description of the non-monotonic changes in the water reorientation dynamics with surface hydrophilicity.

Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines.

Reverse vaccinology is an evolving approach for improving vaccine effectiveness and minimizing adverse responses by limiting immunizations to critical epitopes. Towards this goal, we sought to identify immunogenic amino acid motifs and linear epitopes of the SARS-CoV-2 spike protein that elicit IgG in COVID-19 mRNA vaccine recipients. Paired pre/post vaccination samples from N = 20 healthy adults, and post-vaccine samples from an additional N = 13 individuals were used to immunoprecipitate IgG targets expressed by a bacterial display random peptide library, and preferentially recognized peptides were mapped to the spike primary sequence. The data identify several distinct amino acid motifs recognized by vaccine-induced IgG, a subset of those targeted by IgG from natural infection, which may mimic 3-dimensional conformation (mimotopes). Dominant linear epitopes were identified in the C-terminal domains of the S1 and S2 subunits (aa 558-569, 627-638, and 1148-1159) which have been previously associated with SARS-CoV-2 neutralization in vitro and demonstrate identity to bat coronavirus and SARS-CoV, but limited homology to non-pathogenic human coronavirus. The identified COVID-19 mRNA vaccine epitopes should be considered in the context of variants, immune escape and vaccine and therapy design moving forward.

Correlational study of psychological variables self-confidence and anxiety / Estudo da correlação das variáveis psicológicas autoconfiança e ansiedade / Estudio correlacional de las variables psicológicas autoconfianza y ansiedad

The purpose of this study is to analyze the concurrent validity of the psychological variables self-confidence and anxiety among the psychological measurement instruments: Psychological Characteristics Questionnaire related to Sports Performance (CPRD); Competitive State Anxiety Inventory-2 (CSAI-2); and Sports Psychological Inventory LOEHR. For this purpose, a correlational study was conducted between the selected variables and pertinent aspects of the measurement instruments. The study has revealed that the psychological variables self-confidence and anxiety are relevant in all three instruments, although not in all of the selected items.

O objetivo deste estudo é analisar a validade concorrente das variáveis psicológicas de autoconfiança e ansiedade entre os instrumentos de medição psicológica: Questionário de Características Psicológicas relacionadas ao Desempenho Esportivo (CPRD), Inventário de Ansiedade Estado Competitivo-2 (CSAI-2) e Inventário Psicológico Esportivo LOEHR. Para isso foi realizado um estudo de correlação entre os itens selecionados e coincidentes em tais instrumentos. A análise revelou que as variáveis psicológicas autoconfiança e ansiedade guardam relação nos três instrumentos, mas não em todos os itens selecionados.

El objetivo del presente estudio es analizar la validez concurrente de las variables psicológicas autoconfianza y ansiedad entre los instrumentos de medición psicológica: Cuestionario de Características Psicológicas relacionadas con el Rendimiento Deportivo (CPRD), Competitive State Anxiety Inventory-2 (CSAI-2) e Inventario Psicológico Deportivo LOEHR. Para ello, se ha llevado a cabo un estudio correlacional entre los ítems seleccionados y coincidentes en dichos instrumentos. El estudio ha revelado que las variables psicológicas autoconfianza y ansiedad guardan relación en los tres instrumentos, aunque no en todos los ítems seleccionados.

Gender equity in physical education: The use of language / Igualdade de gênero em educação física: o uso da linguagem / La equidad de género en la educación física: el uso de lenguaje

This study analyzed Spanish teachers' behavior and the transmission of gender stereotypes. We observed 48 physical education lessons given by four Spanish teachers (two men and two women). Descriptive codes, which were generated iteratively, were clustered, categorized, integrated, recoded, and re-categorized. They allowed us to identify four major themes related to the transmission of gender stereotypes of teachers: male generics, stereotyped expressions, nominative attention, and priority order. We used a coding sheet as well as audio and video recordings to register the categories. The Kruskal-Wallis test produced significance levels lower than .05, resulting in the rejection of the null hypothesis. Sexist behavior was found in the male generics, nominative attention, and priority order. However, we found no difference in stereotyped expressions...

"Igualdade de gênero em educação física: O uso da linguagem." O objetivo do estudo foi analisar o comportamento dos professores espanhóis na transmissão de estereótipos de gênero para os seus alunos. Observou-se 48 aulas de educação física dadas por quatro professores espanhóis (dois homens e duas mulheres). Os códigos descritivos, que foram gerados de forma iterativa, foram agrupados, categorizados, integrados, recodificados e reclassificados. Identificou-se quatro variáveis relacionando o professorado e a sua transmissão dos estereótipos de gênero: masculinos genéricos, expressões estereotipadas, atenção nominativa e ordem de prioridade. Utilizou-se uma folha de codificação, bem como gravações de áudio e vídeo para os registros. Níveis de significância no teste de Kruskal-Wallis inferiores 0,05 permitiram rejeitar a hipótese nula. Comportamentos sexistas foram encontrados no uso de masculino genérico, a atenção nominativa e ordem de prioridade. No entanto, não foi encontrada diferenças nas expressões estereotipadas...

"La equidad de género en la educación física: El uso del lenguaje." El objetivo de este estudio es analizar el comportamiento de los profesores españoles en la transmisión de estereotipos de género hacia su alumnado. Para ello, se han observado 48 clases de educación física impartidas por cuatro profesores españoles (dos hombres y dos mujeres). Los códigos descriptivos que se generaron de forma interactiva, fueron agrupados, categorizados, integrados, recodificados y recategorizados. Se identificaron cuatro variables relacionadas con el profesorado y su transmisión de estereotipos de género: masculino genérico, expresiones estereotipadas, atención nominativa y orden de prelación. Para el registro de las categorías se utilizó una hoja de observación, junto con grabaciones de audio y vídeo. Niveles de significación en el test de Kruskal-Wallis inferiores a ,05 permitieron rechazar la hipótesis nula. Se encontraron comportamientos sexistas en el uso del masculino genérico, la atención nominativa y el orden de prelación. Sin embargo, no se encontraron diferencias en las expresiones estereotipadas...

A density functional theory study of phenyl formation initiated by ethynyl radical (C2H*) and ethyne (C2H2).

An ab initio computational density functional theory (DFT) was used to study the formation of the first cyclic molecule (phenyl) initiated by the ethynyl radical (C(2)H*). The study covers a competition reaction between the addition reactions of C(2)H* with ethyne (C(2)H(2)) and some molecular re-arrangement schemes. The minimum energy paths of the preferred cyclic formation route were characterized. A thorough thermochemical analysis was performed by evaluating the differences in the energy of activation (DeltaE), enthalpy (DeltaH), and Gibb's free energy (DeltaG) of the optimized stable and transition state (TS) molecules. The reaction temperatures were set to normal (T = 298 K) and combustion (T = 1,200 K) conditions.