Detalhe da pesquisa
1.
Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29158273
2.
Preclinical safety evaluation of IQG-607 in rats: Acute and repeated dose toxicity studies.
Regul Toxicol Pharmacol
; 86: 11-17, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28232042
3.
Pulse Proteolysis and Precipitation for Target Identification.
J Proteome Res
; 15(7): 2236-45, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255303
4.
Production of recombinant human annexin V by fed-batch cultivation.
BMC Biotechnol
; 14: 33, 2014 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24766778
5.
Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis.
Invest New Drugs
; 32(6): 1301-7, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25052233
6.
Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation.
J Nat Prod
; 77(10): 2190-5, 2014 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25302422
7.
Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase.
Arch Biochem Biophys
; 536(1): 53-63, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23756762
8.
Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach.
J Chem Inf Model
; 53(9): 2390-401, 2013 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23889525
9.
Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.
J Biol Inorg Chem
; 17(2): 275-83, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21952749
10.
Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain.
Arch Biochem Biophys
; 517(1): 1-11, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119138
11.
UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation.
Arch Biochem Biophys
; 505(2): 202-12, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035424
12.
Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products.
Arch Biochem Biophys
; 509(1): 108-15, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295009
13.
Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23).
Arch Biochem Biophys
; 512(2): 143-53, 2011 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21672513
14.
Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase.
J Struct Biol
; 169(3): 413-23, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20035876
15.
The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
Arch Biochem Biophys
; 497(1-2): 35-42, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20226755
16.
Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Bioorg Med Chem
; 18(13): 4769-74, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20570524
17.
Plasmodium falciparum purine nucleoside phosphorylase as a model in the search for new inhibitors by high throughput screening.
Int J Biol Macromol
; 165(Pt B): 1832-1841, 2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33075341
18.
The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
J Bacteriol
; 191(8): 2884-7, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181797
19.
In vivo up-regulation of kinin B1 receptors after treatment with Porphyromonas gingivalis lipopolysaccharide in rat paw.
J Pharmacol Exp Ther
; 330(3): 756-63, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19561153
20.
Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Arch Biochem Biophys
; 486(2): 155-64, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19416718