Detalhe da pesquisa
1.
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Nat Immunol
; 11(12): 1119-26, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21057510
2.
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.
Nat Immunol
; 8(12): 1372-9, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994023
3.
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.
Nat Immunol
; 8(12): 1363-71, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994025
4.
Timed action of IL-27 protects from immunopathology while preserving defense in influenza.
PLoS Pathog
; 10(5): e1004110, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24809349
5.
A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes.
J Immunol
; 190(4): 1510-8, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23335749
6.
Independent and interdependent immunoregulatory effects of IL-27, IFN-ß, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.
J Immunol
; 190(7): 3225-34, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23455508
7.
Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice.
Circ Res
; 111(10): 1274-85, 2012 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22927332
8.
Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.
Am J Physiol Heart Circ Physiol
; 305(3): H420-9, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23729211
9.
IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice.
Am J Pathol
; 179(5): 2327-36, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21925473
10.
The WSX-1 pathway restrains intestinal T-cell immunity.
Int Immunol
; 23(2): 129-37, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21233255
11.
Identification of triazolopyridazinones as potent p38α inhibitors.
Bioorg Med Chem Lett
; 22(2): 1226-9, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22196117
12.
IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis.
J Immunol
; 183(3): 2037-44, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19596985
13.
Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Bioorg Med Chem Lett
; 20(5): 1680-4, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20138761
14.
IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.
Int Immunol
; 20(6): 739-52, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18375937
15.
Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Bioorg Med Chem Lett
; 19(16): 4724-8, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19574047
16.
Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF.
J Leukoc Biol
; 82(4): 915-25, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17652450
17.
Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors.
J Med Chem
; 53(17): 6398-411, 2010 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20712346
18.
Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.
J Med Chem
; 53(7): 2973-85, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218619
19.
3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
J Med Chem
; 51(20): 6280-92, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18817364
20.
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
Blood
; 110(7): 2528-36, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17609432