Pesquisa | BVS IEC

1.

Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape.

Vis, D J; Lewin, J; Liao, R G; Mao, M; Andre, F; Ward, R L; Calvo, F; Teh, B T; Camargo, A A; Knoppers, B M; Sawyers, C L; Wessels, L F A; Lawler, M; Siu, L L; Voest, E.

Ann Oncol ; 28(5): 1145-1151, 2017 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-28453708

2.

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

Craft, N; Shostak, Y; Carey, M; Sawyers, C L.

Nat Med ; 5(3): 280-5, 1999 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-10086382

3.

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice.

Klein, K A; Reiter, R E; Redula, J; Moradi, H; Zhu, X L; Brothman, A R; Lamb, D J; Marcelli, M; Belldegrun, A; Witte, O N; Sawyers, C L.

Nat Med ; 3(4): 402-8, 1997 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-9095173

4.

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

Sawyers, C L; McLaughlin, J; Witte, O N.

J Exp Med ; 181(1): 307-13, 1995 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-7807010

5.

Differential complementation of Bcr-Abl point mutants with c-Myc.

Afar, D E; Goga, A; McLaughlin, J; Witte, O N; Sawyers, C L.

Science ; 264(5157): 424-6, 1994 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-8153630

6.

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification.

Gorre, M E; Mohammed, M; Ellwood, K; Hsu, N; Paquette, R; Rao, P N; Sawyers, C L.

Science ; 293(5531): 876-80, 2001 Aug 03.

Artigo em Inglês | MEDLINE | ID: mdl-11423618

7.

A cytoplasmic inhibitor of the JNK signal transduction pathway.

Dickens, M; Rogers, J S; Cavanagh, J; Raitano, A; Xia, Z; Halpern, J R; Greenberg, M E; Sawyers, C L; Davis, R J.

Science ; 277(5326): 693-6, 1997 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-9235893

8.

Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.

Senechal, K; Heaney, C; Druker, B; Sawyers, C L.

Mol Cell Biol ; 18(9): 5082-90, 1998 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-9710592

9.

Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer.

Abreu-Martin, M T; Chari, A; Palladino, A A; Craft, N A; Sawyers, C L.

Mol Cell Biol ; 19(7): 5143-54, 1999 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-10373563

10.

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

Neshat, M S; Raitano, A B; Wang, H G; Reed, J C; Sawyers, C L.

Mol Cell Biol ; 20(4): 1179-86, 2000 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-10648603

11.

In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR).

Nickerson, T; Chang, F; Lorimer, D; Smeekens, S P; Sawyers, C L; Pollak, M.

Cancer Res ; 61(16): 6276-80, 2001 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-11507082

12.

Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.

Craft, N; Chhor, C; Tran, C; Belldegrun, A; DeKernion, J; Witte, O N; Said, J; Reiter, R E; Sawyers, C L.

Cancer Res ; 59(19): 5030-6, 1999 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-10519419

13.

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

Shuai, K; Halpern, J; ten Hoeve, J; Rao, X; Sawyers, C L.

Oncogene ; 13(2): 247-54, 1996 Jul 18.

Artigo em Inglês | MEDLINE | ID: mdl-8710363

14.

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

Goga, A; Liu, X; Hambuch, T M; Senechal, K; Major, E; Berk, A J; Witte, O N; Sawyers, C L.

Oncogene ; 11(4): 791-9, 1995 Aug 17.

Artigo em Inglês | MEDLINE | ID: mdl-7651743

15.

Functional role for the c-Abl tyrosine kinase in meiosis I.

Kharbanda, S; Pandey, P; Morris, P L; Whang, Y; Xu, Y; Sawant, S; Zhu, L J; Kumar, N; Yuan, Z M; Weichselbaum, R; Sawyers, C L; Pandita, T K; Kufe, D.

Oncogene ; 16(14): 1773-7, 1998 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-9583675

16.

Molecular studies in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.

Sawyers, C L.

Semin Hematol ; 38(3 Suppl 8): 15-21, 2001 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-11526597

17.

Molecular abnormalities in myeloid leukemias and myelodysplastic syndromes.

Sawyers, C L.

Leuk Res ; 22(12): 1113-22, 1998 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-9922075

18.

Research on resistance to cancer drug Gleevec.

Sawyers, C L.

Science ; 294(5548): 1834, 2001 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-11732550

19.

Molecular consequences of the BCR-ABL translocation in chronic myelogenous leukemia.

Sawyers, C L.

Leuk Lymphoma ; 11 Suppl 2: 101-3, 1993.

Artigo em Inglês | MEDLINE | ID: mdl-8124222

20.

The role of myc in transformation by BCR-ABL.

Sawyers, C L.

Leuk Lymphoma ; 11 Suppl 1: 45-6, 1993.

Artigo em Inglês | MEDLINE | ID: mdl-8251915

BVS IEC

Instituto Evandro Chagas

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Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape.

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice.

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

Differential complementation of Bcr-Abl point mutants with c-Myc.

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification.

A cytoplasmic inhibitor of the JNK signal transduction pathway.

Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.

Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer.

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR).

Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

Functional role for the c-Abl tyrosine kinase in meiosis I.

Molecular studies in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.

Molecular abnormalities in myeloid leukemias and myelodysplastic syndromes.

Research on resistance to cancer drug Gleevec.

Molecular consequences of the BCR-ABL translocation in chronic myelogenous leukemia.

The role of myc in transformation by BCR-ABL.