Detalhe da pesquisa
1.
Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity.
Cell
; 168(5): 867-877.e13, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235198
2.
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia.
Nature
; 597(7877): 571-576, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34497422
3.
Biocompatible Cationic Lipoamino Acids as Counterions for Oral Administration of API-Ionic Liquids.
Pharm Res
; 39(10): 2405-2419, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35661084
4.
Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide.
Pharm Res
; 38(6): 1125-1137, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34100217
5.
Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor.
Molecules
; 26(13)2021 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34206465
6.
Driving antimalarial design through understanding of target mechanism.
Biochem Soc Trans
; 48(5): 2067-2078, 2020 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32869828
7.
Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives.
Drug Metab Dispos
; 47(2): 164-172, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30478158
8.
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
Mol Pharmacol
; 94(1): 770-783, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691279
9.
Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations.
Mol Pharm
; 15(12): 5678-5696, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30376336
10.
Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies.
Mol Pharm
; 14(11): 3669-3683, 2017 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954512
11.
Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.
Biochem J
; 473(19): 3189-204, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27462122
12.
Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist.
Proc Natl Acad Sci U S A
; 111(12): 4614-9, 2014 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24619092
13.
Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.
Mol Pharmacol
; 90(6): 715-725, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27683013
14.
Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior.
J Pharmacol Exp Ther
; 359(2): 354-365, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27630144
15.
Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials.
J Mol Recognit
; 29(6): 281-91, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26804042
16.
A new mechanism of allostery in a G protein-coupled receptor dimer.
Nat Chem Biol
; 10(9): 745-52, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25108820
17.
VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model.
Clin Exp Pharmacol Physiol
; 43(10): 976-82, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377874
18.
Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.
J Biol Chem
; 289(48): 33701-11, 2014 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25326383
19.
Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor.
J Biol Chem
; 289(34): 23817-37, 2014 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006252
20.
Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations.
Mol Pharm
; 12(6): 1980-91, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25905624