1.
Bioorg Med Chem Lett
; 12(3): 371-4, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11814799
RESUMO
Eight analogues of (-)-16-chloro-1-dehydro-6S-bromovincadifformine 1 were synthesized and evaluated for cytotoxicity in L1210 cell culture. None of the new compounds was more active than 1 but the modulation at C6, C16 and on the aromatic ring at C10 informs about structure-activity relationships within this series.