Detalhe da pesquisa
1.
Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease.
Cytotherapy
; 23(2): 111-118, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33246883
2.
Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor.
Invest New Drugs
; 37(2): 271-281, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30073466
3.
Quantum imaging in biological samples.
Nat Methods
; 16(3): 214, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30814706
4.
Spatially resolved isotope labeling.
Nat Methods
; 16(4): 287, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30923382
5.
Time-resolved protein activation.
Nat Methods
; 16(7): 579, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31249405
6.
Forced cell cycle exit and modulation of GABAA, CREB, and GSK3ß signaling promote functional maturation of induced pluripotent stem cell-derived neurons.
Am J Physiol Cell Physiol
; 310(7): C520-41, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26718628
7.
Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA.
J Physiol
; 594(22): 6583-6594, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27616476
8.
Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 26(19): 4729-4734, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27575470
9.
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Bioorg Med Chem Lett
; 26(8): 2057-64, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951753
10.
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 25(17): 3575-81, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26199119
11.
INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.
Nat Cancer
; 5(3): 481-499, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38233483
12.
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Hum Mol Genet
; 20(21): 4209-23, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21828077
13.
Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors.
Cell Rep
; 42(4): 112297, 2023 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36961816
14.
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.
Proc Natl Acad Sci U S A
; 106(52): 22299-304, 2009 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20007781
15.
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
J Med Chem
; 65(12): 8345-8379, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500094
16.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discov
; 12(6): 1500-1517, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404998
17.
Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.
Angiogenesis
; 14(4): 533-44, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22045552
18.
3-dimensional printing for the diagnosis of left ventricular outflow tract obstruction after mitral valve replacement.
Interact Cardiovasc Thorac Surg
; 32(5): 724-726, 2021 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33647986
19.
The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis.
Angiogenesis
; 13(3): 259-67, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20803239
20.
Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.
Mol Cancer Res
; 7(4): 601-13, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19372588