Detalhe da pesquisa
1.
Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease.
J Pharmacol Exp Ther
; 380(3): 210-219, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35031585
2.
Abnormal brain structure and behavior in MyD88-deficient mice.
Brain Behav Immun
; 91: 181-193, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33002631
3.
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Diabetes Obes Metab
; 23(3): 700-710, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33289350
4.
Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.
J Immunol
; 202(10): 2888-2906, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30988116
5.
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.
Antimicrob Agents Chemother
; 58(6): 3233-44, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24663024
6.
Diagnostic yield of endoscopy in patients with abdominal complaints: incremental value of faecal calprotectin on guidelines of appropriateness.
BMC Gastroenterol
; 14: 57, 2014 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24679065
7.
Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor.
J Toxicol Pathol
; 27(1): 31-42, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24791065
8.
Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease.
Blood Adv
; 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38640200
9.
Evaluation of the use of static and dynamic models to predict drug-drug interaction and its associated variability: impact on drug discovery and early development.
Drug Metab Dispos
; 40(8): 1495-507, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22566536
10.
Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial.
Clin Pharmacol Drug Dev
; 11(5): 654-665, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35019238
11.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734694
12.
Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1.
Bioorg Med Chem Lett
; 20(19): 5847-52, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20727752
13.
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
J Med Chem
; 63(21): 12526-12541, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696648
14.
The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites.
Drug Metab Dispos
; 36(9): 1780-5, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18515330
15.
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
CPT Pharmacometrics Syst Pharmacol
; 7(3): 135-146, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29349875
16.
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
J Med Chem
; 61(12): 5235-5244, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856615
17.
Broad analgesic activity of a novel, selective M1 agonist.
Neuropharmacology
; 123: 233-241, 2017 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28623171
18.
Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.
Drug Discov Today
; 22(10): 1447-1459, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28476536
19.
Outbreak of Salmonella javiana infection at a children's hospital.
Infect Control Hosp Epidemiol
; 27(6): 586-92, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16755478
20.
M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier.
Am J Cancer Res
; 6(4): 806-18, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27186432