Detalhe da pesquisa
1.
Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.
J Virol
; 94(24)2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32907977
2.
A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'-C-Methylguanosine for the Treatment of Dengue Virus Infection.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32958712
3.
NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues.
J Virol
; 94(1)2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31597763
4.
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
PLoS Pathog
; 12(8): e1005737, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27500641
5.
Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.
Bioorg Med Chem Lett
; 28(13): 2324-2327, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29801997
6.
A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J Biol Chem
; 291(16): 8541-8, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26872970
7.
A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities.
J Biol Chem
; 288(43): 31105-14, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24025331
8.
Ligand-bound structures of the dengue virus protease reveal the active conformation.
J Virol
; 86(1): 438-46, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22031935
9.
The role of TBK1 and IKKε in the expression and activation of Pellino 1.
Biochem J
; 434(3): 537-48, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21204785
10.
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Sci Transl Med
; 13(579)2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536278
11.
HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway.
FEBS Lett
; 582(29): 4023-31, 2008 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19026643
12.
Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.
J Biomol Screen
; 20(1): 153-63, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25252731
13.
Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.
Antiviral Res
; 119: 36-46, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896272
14.
Crystallographic structure of ubiquitin in complex with cadmium ions.
BMC Res Notes
; 2: 251, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20003470