1.
Antimicrob Agents Chemother
; 60(2): 1137-40, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26596950
RESUMO
The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocyclic drugs may represent a new lead in the treatment of human African trypanosomiasis.