RESUMO
Here we present antiestrogenic effects of Knotolan, a new dietary lignan from Abies sibirica raw material. Knotolan abolished growth-stimulating effects of 17ß-estradiol on hormone-dependent MCF-7 cells.
Assuntos
Neoplasias da Mama/tratamento farmacológico , Butileno Glicóis/uso terapêutico , Lignanas/uso terapêutico , Neoplasias Hormônio-Dependentes/tratamento farmacológico , Abies/química , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Estradiol/farmacologia , Feminino , HumanosRESUMO
Changes in growth characteristics (the growth in a mat of normal cells, contact inhibition of division, growth-substrate dependence, dependence on the serum growth factors) and tumourigenicity were compared in 6 cells lines of mice and rats during their in vitro and in vivo long passages. All these factors progressed independently of a tumourigenicity increase, i.e. they obeyed the Fould principle. The trait responsible for the cell capacity to proliferate on a layer of normal cells proved to be the most correct one relative to tumourigenicity prediction.