Pesquisa | BVS IEC

1.

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.

Aliaga, Leonardo; Lai, Chen; Yu, Jia; Chub, Nikolai; Shim, Hoon; Sun, Lixin; Xie, Chengsong; Yang, Wan-Jou; Lin, Xian; O'Donovan, Michael J; Cai, Huaibin.

Hum Mol Genet ; 22(21): 4293-305, 2013 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-23771029

2.

Side effect profiles of different opioids in the perioperative setting: are they different and can we reduce them?

Shim, Hoon; Gan, Tong Joo.

Br J Anaesth ; 123(3): 266-268, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31326087

3.

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.

Lin, Xian; Parisiadou, Loukia; Sgobio, Carmelo; Liu, Guoxiang; Yu, Jia; Sun, Lixin; Shim, Hoon; Gu, Xing-Long; Luo, Jing; Long, Cai-Xia; Ding, Jinhui; Mateo, Yolanda; Sullivan, Patricia H; Wu, Ling-Gang; Goldstein, David S; Lovinger, David; Cai, Huaibin.

J Neurosci ; 32(27): 9248-64, 2012 Jul 04.

Artigo em Inglês | MEDLINE | ID: mdl-22764233

4.

Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.

Shim, Hoon; Wang, Chih-Ting; Chen, Yen-Lin; Chau, Viet Q; Fu, Kevin G; Yang, Jianqi; McQuiston, A Rory; Fisher, Rory A; Chen, Ching-Kang.

J Biol Chem ; 287(18): 14873-9, 2012 Apr 27.

Artigo em Inglês | MEDLINE | ID: mdl-22371490

5.

IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.

Macey, Matthew R; Sturgill, Jamie L; Morales, Johanna K; Falanga, Yves T; Morales, Joshua; Norton, Sarah K; Yerram, Nitin; Shim, Hoon; Fernando, Josephine; Gifillan, Alasdair M; Gomez, Gregorio; Schwartz, Lawrence; Oskeritzian, Carole; Spiegel, Sarah; Conrad, Daniel; Ryan, John J.

J Immunol ; 184(9): 4688-95, 2010 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-20304823

6.

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

Wang, Lizhen; Xie, Chengsong; Greggio, Elisa; Parisiadou, Loukia; Shim, Hoon; Sun, Lixin; Chandran, Jayanth; Lin, Xian; Lai, Chen; Yang, Wan-Jou; Moore, Darren J; Dawson, Ted M; Dawson, Valina L; Chiosis, Gabriela; Cookson, Mark R; Cai, Huaibin.

J Neurosci ; 28(13): 3384-91, 2008 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-18367605

7.

The G59S mutation in p150(glued) causes dysfunction of dynactin in mice.

Lai, Chen; Lin, Xian; Chandran, Jayanth; Shim, Hoon; Yang, Wan-Jou; Cai, Huaibin.

J Neurosci ; 27(51): 13982-90, 2007 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-18094236

8.

ALS2/alsin knockout mice and motor neuron diseases.

Cai, Huaibin; Shim, Hoon; Lai, Chen; Xie, Chengsong; Lin, Xian; Yang, Wan Jou; Chandran, Jayanth.

Neurodegener Dis ; 5(6): 359-66, 2008.

Artigo em Inglês | MEDLINE | ID: mdl-18714162

9.

Genetic ablation of dynactin p150^Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice.

Yu, Jia; Lai, Chen; Shim, Hoon; Xie, Chengsong; Sun, Lixin; Long, Cai-Xia; Ding, Jinhui; Li, Yan; Cai, Huaibin.

Mol Neurodegener ; 13(1): 10, 2018 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-29490687

10.

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.

Lai, Chen; Xie, Chengsong; McCormack, Stefanie G; Chiang, Hsueh-Cheng; Michalak, Marta K; Lin, Xian; Chandran, Jayanth; Shim, Hoon; Shimoji, Mika; Cookson, Mark R; Huganir, Richard L; Rothstein, Jeffrey D; Price, Donald L; Wong, Philip C; Martin, Lee J; Zhu, J Julius; Cai, Huaibin.

J Neurosci ; 26(45): 11798-806, 2006 Nov 08.

Artigo em Inglês | MEDLINE | ID: mdl-17093100

11.

Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.

Erie, Elizabeth A; Shim, Hoon; Smith, Aleah L; Lin, Xian; Keyvanfar, Keyvan; Xie, Chengsong; Chen, Jichun; Cai, Huaibin.

J Neuroimmunol ; 182(1-2): 226-31, 2007 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-17156857

12.

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress.

Cai, Huaibin; Lin, Xian; Xie, Chengsong; Laird, Fiona M; Lai, Chen; Wen, Hongjin; Chiang, Hsueh-Cheng; Shim, Hoon; Farah, Mohamed H; Hoke, Ahmet; Price, Donald L; Wong, Philip C.

J Neurosci ; 25(33): 7567-74, 2005 Aug 17.

Artigo em Inglês | MEDLINE | ID: mdl-16107644

13.

Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and ß2 subunits.

Bell, Karen A; Shim, Hoon; Chen, Ching-Kang; McQuiston, A Rory.

Neuropharmacology ; 61(8): 1379-88, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-21878344

14.

Functional redundancy of R7 RGS proteins in ON-bipolar cell dendrites.

Chen, Frank S; Shim, Hoon; Morhardt, Duncan; Dallman, Rebecca; Krahn, Elizabeth; McWhinney, Ludine; Rao, Anjali; Gold, Stephen J; Chen, Ching-Kang.

Invest Ophthalmol Vis Sci ; 51(2): 686-93, 2010 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-19797210

15.

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.

Lai, Chen; Xie, Chengsong; Shim, Hoon; Chandran, Jayanth; Howell, Brian W; Cai, Huaibin.

Mol Brain ; 2: 23, 2009 Jul 24.

Artigo em Inglês | MEDLINE | ID: mdl-19630956

16.

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

Lin, Xian; Parisiadou, Loukia; Gu, Xing-Long; Wang, Lizhen; Shim, Hoon; Sun, Lixin; Xie, Chengsong; Long, Cai-Xia; Yang, Wan-Jou; Ding, Jinhui; Chen, Zsu Zsu; Gallant, Paul E; Tao-Cheng, Jung-Hwa; Rudow, Gay; Troncoso, Juan C; Liu, Zhihua; Li, Zheng; Cai, Huaibin.

Neuron ; 64(6): 807-27, 2009 Dec 24.

Artigo em Inglês | MEDLINE | ID: mdl-20064389

17.

Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.

Wang, Lizhen; Shim, Hoon; Xie, Chengsong; Cai, Huaibin.

Neurobiol Aging ; 29(3): 357-67, 2008 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-17157415

18.

Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice.

Lin, Xian; Shim, Hoon; Cai, Huaibin.

Neurobiol Aging ; 28(10): 1628-30, 2007 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-16973244

19.

Genetic defects in copper metabolism.

Shim, Hoon; Harris, Z Leah.

J Nutr ; 133(5 Suppl 1): 1527S-31S, 2003 05.

Artigo em Inglês | MEDLINE | ID: mdl-12730458

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