Detalhe da pesquisa
1.
Quinuclidine N-oxygenation mediated by flavin-containing monooxygenase (FMO) 1 and FMO3 in kidney and liver microsomes from humans, monkeys, dogs, and pigs.
Drug Metab Dispos
; 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38769015
2.
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells.
Chem Res Toxicol
; 37(5): 671-674, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38626399
3.
Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.
Biol Pharm Bull
; 47(3): 635-640, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494736
4.
Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.
Biol Pharm Bull
; 47(5): 1028-1032, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38797695
5.
Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes.
Drug Metab Dispos
; 51(1): 123-129, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35772770
6.
Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources.
Drug Metab Dispos
; 51(7): 884-891, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37041084
7.
Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6.
Drug Metab Dispos
; 2023 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37879849
8.
Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers.
J Epidemiol
; 33(6): 311-320, 2023 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34690243
9.
Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in Silico Liver-to-Plasma Partition Coefficients.
Biol Pharm Bull
; 46(9): 1316-1323, 2023 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37380443
10.
Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in Silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats.
Biol Pharm Bull
; 46(8): 1133-1140, 2023 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37316265
11.
Plasma and Hepatic Exposures of Celecoxib and Diclofenac Prescribed Alone in Patients with Cytochrome P450 2C9*3 Modeled after Virtual Oral Administrations and Likely Associated with Adverse Drug Events Reported in a Japanese Database.
Biol Pharm Bull
; 46(6): 856-863, 2023 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37062721
12.
A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis - A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir.
J Infect Chemother
; 29(11): 1068-1070, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37437659
13.
Diagnosis-specific Cumulative Incidence of Return-to-work, Resignation, and Death Among Long-term Sick-listed Employees: Findings From the Japan Epidemiology Collaboration on Occupational Health Study.
J Epidemiol
; 32(9): 431-437, 2022 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33716270
14.
Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals.
Biol Pharm Bull
; 45(8): 1142-1157, 2022 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35644566
15.
Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans.
Biol Pharm Bull
; 45(12): 1812-1817, 2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36171106
16.
Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals.
Biol Pharm Bull
; 45(1): 124-128, 2022 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34732590
17.
In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals.
Chem Res Toxicol
; 34(2): 507-513, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33433197
18.
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats.
Chem Res Toxicol
; 34(10): 2180-2183, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34586804
19.
Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model.
Chem Res Toxicol
; 34(2): 522-528, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33198470
20.
Smoking Cessation, Weight Gain, and the Trajectory of Estimated Risk of Coronary Heart Disease: 8-Year Follow-up From a Prospective Cohort Study.
Nicotine Tob Res
; 23(1): 85-91, 2021 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31504860