Detalhe da pesquisa
1.
Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo.
Drug Metab Dispos
; 51(7): 851-861, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37055191
2.
LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy.
Anal Biochem
; 602: 113766, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32389692
3.
Immunoaffinity microflow liquid chromatography/tandem mass spectrometry for the quantitation of PD1 and PD-L1 in human tumor tissues.
Rapid Commun Mass Spectrom
; 34(20): e8896, 2020 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32666620
4.
Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.
J Pharmacol Exp Ther
; 368(1): 136-145, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30361237
5.
Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.
Anal Biochem
; 568: 41-50, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605634
6.
Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.
Drug Metab Dispos
; 46(2): 178-188, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29162614
7.
Antibody Drug-Target Engagement Measurement in Tissue Using Quantitative Affinity Extraction Liquid Chromatography-Mass Spectrometry: Method Development and Qualification.
Anal Chem
; 89(9): 5115-5123, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28383906
8.
Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.
J Pharmacol Exp Ther
; 358(3): 397-404, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27317801
9.
The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.
Anal Biochem
; 503: 71-8, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27033006
10.
Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.
Amino Acids
; 47(3): 603-15, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534430
11.
Challenges in accurate quantitation of lysophosphatidic acids in human biofluids.
J Lipid Res
; 55(8): 1784-96, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24872406
12.
Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.
Dig Dis Sci
; 59(2): 365-74, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24048683
13.
Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression.
J Lipid Res
; 54(9): 2400-9, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23614904
14.
Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease.
Toxicol Appl Pharmacol
; 268(2): 132-40, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23391614
15.
Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor.
BMC Pharmacol
; 12: 2, 2012 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22475049
16.
Simultaneous measurement of mouse and human albumin in chimeric mice with humanized livers.
Bioanalysis
; 14(5): 267-278, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35195037
17.
Pegbelfermin selectively reduces secondary bile acid concentrations in patients with non-alcoholic steatohepatitis.
JHEP Rep
; 4(1): 100392, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34977519
18.
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
Cell Metab
; 34(11): 1732-1748.e5, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36323235
19.
Metabolomic and transcriptomic changes induced by overnight (16 h) fasting in male and female Sprague-Dawley rats.
Chem Res Toxicol
; 24(4): 481-7, 2011 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21381695
20.
Estimation of the extent of in vivo formation of a mutagenic aromatic amine from a potent thyromimetic compound: correlation of in vitro and in vivo findings.
Chem Res Toxicol
; 24(6): 905-12, 2011 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21574629