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A phenomenological approach, based on a combination of a damage mechanism and a crystal plasticity model, is proposed to model a process of strain localization in Ti-6AI-4V at a high strain rate of 103 s-1. The proposed model is first calibrated employing a three-dimensional representative volume element model. The calibrated parameters are then employed to investigate the process of onset of strain localization in the studied material. A suitable mesh size is chosen for the proposed model by implementing a mesh-sensitivity study. The influence of boundary conditions on the initiation of the strain localization is also studied. A variation of crystallographic orientation in the studied material after the deformation process is characterized, based on results for different boundary conditions. The study reveals that the boundary conditions significantly influence the formation of shear bands as well as the variation of crystallographic orientation in the studied material. Results also indicate that the onset of strain localization can affect considerably the material's behaviour. This article is part of the theme issue 'Modelling of dynamic phenomena and localization in structured media (part 2)'.
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BACKGROUND: Bone is a living material that, unlike man-made ones, demonstrates continuous adaptation of its structure and mechanical properties to resist the imposed mechanical loading. Adaptation in trabecular bone is characterised by improvement of its stiffness in the loading direction and respective realignment of trabecular load-bearing architecture. Considerable experimental and simulation evidence of trabecular bone adaptation to its mechanical environment at the tissue- and organ-levels was obtained, while little attention was given to the trabecula-level of this process. This study aims to describe and classify load-driven morphological changes at the level of individual trabeculae and to propose their drivers. METHOD: For this purpose, a well-established mechanoregulation-based numerical model of bone adaptation was implemented in a user-defined subroutine that changed the structural and mechanical properties of trabeculae based on the magnitude of a mechanical stimulus. This subroutine was used in conjunction with finite-element models of variously shaped structures representing trabeculae loaded in compression or shear. RESULTS: In all analysed cases, trabeculae underwent morphological evolution under applied compressive or shear loading. Among twelve cases analysed, six main mechanisms of morphological evolution were established: reorientation, splitting, merging, full resorption, thinning, and thickening. Moreover, all simulated cases presented the ability to reduce the mean value of von Mises stress while increasing their ability to resist compressive/shear loading during adaptation. CONCLUSION: This study evaluated morphological and mechanical changes in trabeculae of different shapes in response to compressive or shear loadings and compared them based on the analysis of von Mises stress distribution as well as profiles of normal and shear stresses in the trabeculae at different stages of their adaptation.
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Osso e Ossos , Modelos Biológicos , Humanos , Estresse Mecânico , Suporte de Carga , Simulação por Computador , Análise de Elementos FinitosRESUMO
Porous polymeric scaffolds are used in tissue engineering to maintain or replace damaged biological tissues. Once embedded in body, they are involved into different physical and biological processes, among which their degradation and dissolution of their material can be singled out as one of the most important ones. Degradation parameters depend mostly on the properties of both the material and surrounding native tissues, which can substantially alter the original mechanical parameters of the scaffolds. The aim of this study is to examine the change in the effective mechanical properties of functionally graded additively manufactured polylactide scaffolds with a linear porosity gradient and morphology based on triply periodic minimal surfaces during simultaneous degradation and compressive loading. Two main types of scaffold-degradation processes, bulk and surface erosions are simulated with two suggested modelling methods. The fundamental differences in the proposed approaches are identified and the influence of different types of scaffold morphology on the change in effective elastic properties is evaluated. The results of this study can be useful for design of optimal scaffolds taking into account the effect of the degradation process on their structural integrity.
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Poliésteres , Alicerces Teciduais , Alicerces Teciduais/química , Porosidade , Poliésteres/química , Engenharia Tecidual/métodos , Propriedades de Superfície , Polímeros/química , Teste de MateriaisRESUMO
Thanks to the distinctive morphology of graphite particles in its microstructure, compacted graphite iron (CGI) exhibits excellent thermal conductivity together with high strength and durability. CGI is extensively used in many applications, e.g., engine cylinder heads and brakes. The structural integrity of such metal-matrix materials is controlled by the generation and growth of microcracks. Although the effects of the volume fraction and morphology of graphite inclusions on the tensile response of CGI were investigated in recent years, their influence on crack initiation is still unknown. Experimental studies of crack initiation require a considerable amount of time and resources due to the highly complicated geometries of graphite inclusions scattered throughout the metallic matrix. Therefore, developing a 2D computational framework for CGI with a random microstructure capable of predicting the crack initiation and path is desirable. In this work, an integrated numerical model is developed for the analysis of the effects of volume fraction and nodularity on the mechanical properties of CGI as well as its damage and failure behaviours. Finite-element models of random microstructure are generated using an in-house Python script. The determination of spacings between a graphite inclusion and its four adjacent particles is performed with a plugin, written in Java and implemented in ImageJ. To analyse the orientation effect of inclusions, a statistical analysis is implemented for representative elements in this research. Further, Johnson-Cook damage criteria are used to predict crack initiation in the developed models. The numerical simulations are validated with conventional tensile-test data. The created models can support the understanding of the fracture behaviour of CGI under mechanical load, and the proposed approach can be utilised to design metal-matrix composites with optimised mechanical properties and performance.
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BACKGROUND AND OBJECTIVE: Atherosclerotic lesions of coronary arteries (stenosis) are caused by the buildup of lipids and blood-borne substances within the artery wall. Their qualitative and rapid assessment is still a challenging task. The primary therapy for this pathology involves implanting coronary stents, which help to restore the blood flow in atherosclerosis-prone arteries. In-stent restenosis is a stenting-procedure complication detected in about 10-40% of patients. A numerical study using 2-way fluid-structure interaction (FSI) assesses the stenting procedure quality and can decrease the number of negative post-operative results. Nevertheless, boundary conditions (BCs) used in simulation play a crucial role in implementation of an adequate computational analysis. METHODS: Three CoCr stents designs were modelled with the suggested approach. A multi-layer structure describing the artery and plaque with anisotropic hyperelastic mechanical properties was adopted in this study. Two kinds of boundary conditions for a solid domain were examined - fixed support (FS) and remote displacement (RD) - to assess their impact on the hemodynamic parameters to predict restenosis. Additionally, the influence of artery elongation (short-artery model vs. long-artery model) on numerical results with the FS boundary condition was analyzed. RESULTS: The comparison of FS and RD boundary conditions demonstrated that the variation of hemodynamic parameters values did not exceed 2%. The analysis of short-artery and long-artery models revealed that the difference in hemodynamic parameters was less than 5.1%, and in most cases, it did not exceed 2.5%. The RD boundary conditions were found to reduce the computation time by up to 1.7-2.0 times compared to FS. Simple stent model was shown to be susceptible to restenosis development, with maximum WSS values equal to 183 Pa, compared to much lower values for other two stents. CONCLUSIONS: The study revealed that the stent design significantly affected the hemodynamic parameters as restenosis predictors. Moreover, the stress-strain state of the system artery-plaque-stent also depends on a proper choice of boundary conditions.
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Sandwich structures made with fibre-reinforced plastics are commonly used in maritime vessels thanks to their high strength-to-weight ratios, corrosion resistance, and buoyancy. Understanding their mechanical performance after moisture uptake and the implications of moisture uptake for their structural integrity and safety within out-of-plane loading regimes is vital for material optimisation. The use of modern methods such as acoustic emission (AE) and machine learning (ML) could provide effective techniques for the assessment of mechanical behaviour and structural health monitoring. In this study, the AE features obtained from quasi-static indentation tests on sandwich structures made from E-glass fibre face sheets with polyvinyl chloride foam cores were employed. Time- and frequency-domain features were then used to capture the relevant information and patterns within the AE data. A k-means++ algorithm was utilized for clustering analysis, providing insights into the principal damage modes of the studied structures. Three ensemble learning algorithms were employed to develop a damage-prediction model for samples exposed and unexposed to seawater and were loaded with indenters of different geometries. The developed models effectively identified all damage modes for the various indenter geometries under different loading conditions with accuracy scores between 86.4 and 95.9%. This illustrates the significant potential of ML for the prediction of damage evolution in composite structures for marine applications.
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Endoprosthetic hip replacement is the conventional way to treat osteoarthritis or a fracture of a dysfunctional joint. Different manufacturing methods are employed to create reliable patient-specific devices with long-term performance and biocompatibility. Recently, additive manufacturing has become a promising technique for the fabrication of medical devices, because it allows to produce complex samples with various structures of pores. Moreover, the limitations of traditional fabrication methods can be avoided. It is known that a well-designed porous structure provides a better proliferation of cells, leading to improved bone remodeling. Additionally, porosity can be used to adjust the mechanical properties of designed structures. This makes the design and choice of the structure's basic cell a crucial task. This study focuses on a novel computational method, based on the basic-cell concept to design a hip endoprosthesis with an unregularly complex structure. A cube with spheroid pores was utilized as a basic cell, with each cell having its own porosity and mechanical properties. A novelty of the suggested method is in its combination of the topology optimization method and the structural design algorithm. Bending and compression cases were analyzed for a cylinder structure and two hip implants. The ability of basic-cell geometry to influence the structure's stress-strain state was shown. The relative change in the volume of the original structure and the designed cylinder structure was 6.8%. Computational assessments of a stress-strain state using the proposed method and direct modeling were carried out. The volumes of the two types of implants decreased by 9% and 11%, respectively. The maximum von Mises stress was 600 MPa in the initial design. After the algorithm application, it increased to 630 MPa for the first type of implant, while it is not changing in the second type of implant. At the same time, the load-bearing capacity of the hip endoprostheses was retained. The internal structure of the optimized implants was significantly different from the traditional designs, but better structural integrity is likely to be achieved with less material. Additionally, this method leads to time reduction both for the initial design and its variations. Moreover, it enables to produce medical implants with specific functional structures with an additive manufacturing method avoiding the constraints of traditional technologies.
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Prótese de Quadril , Humanos , Porosidade , Suporte de CargaRESUMO
Balloon pre-dilation is usually performed before implantation of a nitinol stent in a femoropopliteal artery in a case of severe blockage or calcified plaque. However, its effect on performance of the nitinol stent in a diseased femoropopliteal artery has not been studied yet. This study compares the outcomes of stenting with pre-dilation and without it by modelling the entire processes of stent deployment. Fatigue deformation of the implanted stent is also modelled under diastolic-systolic blood pressure, repetitive bending, torsion, axial compression and their combination. Reduced level of stress in the stent occurs after stenting with pre-dilation, but causing the increased damage in the media layer, i.e. the middle layer of the arterial wall. Generally, pre-dilation increases the risk of nitinol stent's fatigue failure. Additionally, the development of in-stent restenosis is predicted based on the stenting-induced tissue damage in the media layer, and no severe mechanical irritation is induced to the media layer by pre-dilation, stent deployment or fatigue loading.
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Artéria Femoral , Stents , Humanos , Dilatação , Ligas , Desenho de Prótese , Resultado do TratamentoRESUMO
Do extrusion temperature, printing speed, and layer time affect mechanical performance of interlayer bonds in material extrusion additive manufacturing (MEAM)? The question is one of the main challenges in 3D printing of polymers. This article aims to analyze the independent effect of printing parameters on interlayer bonding in MEAM. In previous research, printing parameters were unavoidably interrelated, such as printing speed and layer cooling time. Here, original specimen designs allow the effects to be studied independently for the first time to provide new understanding of the effects of a wide range of thermal factors on mechanical properties of 3D-printed polylactide. The experimental approach used direct GCode design to manufacture specially designed single-filament-thick specimens for tensile testing to measure mechanical and thermal properties normal to the interface between layers. In total, five different extrusion temperatures (a range of 60°C), five different printing speeds (a 16-fold change in the magnitude) and four different layer times (an 8-fold change) were independently studied. The results demonstrate interlayer bond strength to be equivalent to that of the bulk material within experimental scatter. This study provides strong evidence about the crucial role of microscale geometry for apparent interlayer bond strength relative to the role of thermal factors. By designing specimens specifically for the MEAM process, this study clearly demonstrates that bulk-material strength can be achieved for interlayer bonds in MEAM even when printing parameters change severalfold. Widespread industrial and academic efforts to improve interlayer bonding should be refocused to study extrusion geometry-the primary cause of anisotropy in MEAM.
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This study is focused on the deformation behaviour of composites formed by auxetic lattice structures acting as a matrix based on the re-entrant unit-cell geometry with a soft filler, motivated by biomedical applications. Three-dimensional models of two types of the auxetic-lattice structures were manufactured using filament deposition modelling. Numerical finite-element models were developed for computational analysis of the effect of the filler with different mechanical properties on the effective Poisson's ratio and mechanical behaviour of such composites. Tensile tests of 3D-printed auxetic samples were performed with strain measurements using digital image correlation. The use of the filler phase with various elastic moduli resulted in positive, negative, and close-to-zero effective Poisson's ratios. Two approaches for numerical measurement of the Poisson's ratio were used. The failure probability of the two-phase composites with auxetic structure depending on the filler stiffness was investigated by assessing statistical distributions of stresses in the finite-elements models.
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This research is aimed at development of 3D-printed sockets for an orthopaedic prosthesis using methods of pressure redistribution on the inner surface of the socket. Topological freedom provided by modern additive manufacturing allows optimization of the parameters of the socket to create an orthopaedic prosthesis with properties adapted to the needs of a particular patient. This paper proposes an approach to redistribute the pressure in the prosthesis by controlled reinforcement with continuous carbon rods to artificially create zones of higher and lower pressure to facilitate prosthetic wear. Numerical modelling is used for the pre-design of a unique internal architecture of the prosthesis, which can redistribute the pressure on the inner surface of the socket, thus relieving excessive pressure from sensitive soft-tissue zones. The influence of socket thickness, inclination angle of the rods and the elastic behaviour of the polymeric materials on the extent of pressure redistribution is investigated.
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Membros Artificiais , Ortopedia , Humanos , Desenho de Prótese , Impressão TridimensionalRESUMO
The nonlinear interaction of longitudinal vibration and ultrasound in beams with cracks is investigated. The central focus is on the localization effect of this interaction, i.e., the locally enhanced nonlinear vibro-acoustic modulation. Both numerical and experimental investigations are undertaken. The finite element (FE) method is used to investigate different crack models, including the bi-linear crack, open crack, and breathing crack. A parametric study is performed considering different crack depths, locations, and boundary conditions in a two-dimensional beam model. The study shows that observed nonlinearities (i.e., nonlinear crack-wave modulations) are particularly strong in the vicinity of the crack, allowing not only for crack localization but also for the separation of the crack-induced nonlinearity from other sources of nonlinearity.
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Applications of additive manufacturing (AM) in tissue engineering develop rapidly. AM offers layer-by-layer creation of complex objects, developed to restore functionality of, or replace, damaged tissues. Porous 3D-printed functional gradient structures are of particular interest: their special architecture makes it possible to simulate the heterogeneity of the replaced tissue and, by continuously changing the mechanical properties, to avoid the concentration of stresses that can be caused by abrupt geometric changes. Such structures also allow combinations of different types of unit cells and a smooth transition between them, making design of personalised scaffolds with optimal parameters for the replacement of damaged host tissue at the interface between tissues possible. This paper presents the results of development of scaffold structures with gradients of porosity and multi-morphology using unit cells based on triply periodic minimal surfaces (TPMS). The mechanical behaviour of additively manufactured scaffold prototypes made of polylactide acid (PLA) was studied under compressive loading. Strain fields on their surface were captured using the Vic-3d Micro-DIC digital image correlation system and compared with those obtained with detailed numerical simulations, employing elastic-plastic properties of PLA, obtained in experiments. The effect of gradient parameters and unit-cell morphology on the stress distribution in scaffolds was analysed. A smooth gradient transition between cells with different morphologies was found to reduce the probability of structural failure under intense compressive loading. A good agreement between numerical results and experimental data was achieved, which justifies application of the developed approach to design of personalised bone scaffolds.
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The analysis of fibrous structures using micro-computer tomography (µCT) is becoming more important as it provides an opportunity to characterise the mechanical properties and performance of materials. This study is the first attempt to provide computations of fibre crimp for various random fibrous networks (RFNs) based on µCT data. A parametric algorithm was developed to compute fibre crimp in fibres in a virtual domain. It was successfully tested for six different X-ray µCT models of nonwoven fabrics. Computations showed that nonwoven fabrics with crimped fibres exhibited higher crimp levels than those with non-crimped fibres, as expected. However, with the increased fabric density of the non-crimped nonwovens, fibres tended to be more crimped. Additionally, the projected fibre crimp was computed for all three major 2D planes, and the obtained results were statistically analysed. Initially, the algorithm was tested for a small-size, nonwoven model containing only four fibres. The fraction of nearly straight fibres was computed for both crimped and non-crimped fabrics. The mean value of the fibre crimp demonstrated that fibre segments between intersections were almost straight. However, it was observed that there were no perfectly straight fibres in the analysed RFNs. This study is applicable to approach employing a finite-element analysis (FEA) and computational fluid dynamics (CFD) to model/analyse RFNs.
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The use of fibre-reinforced plastics (FRPs) in various industrial applications continues to increase thanks to their good strength-to-weight ratio and impact resistance, as well as the high strength that provides engineers with advanced options for the design of modern structures subjected to a variety of out-of-plane impacts. An assessment of the damage morphology under such conditions using non-destructive techniques could provide useful data for material design and optimisation. This study investigated the damage mechanism and energy-absorption characteristics of E-glass laminates and sandwich structures with GFRP face sheets with PVC cores under quasi-static indentation with conical, square, and hemispherical indenters. An acoustic emission (AE) technique, coupled with a k-means++ pattern-recognition algorithm, was employed to identify the dominant microscopic and macroscopic damage mechanisms. Additionally, a post-mortem damage assessment was performed with X-ray micro computed tomography and scanning electron microscopy to validate the identified clusters. It was found that the specific energy absorption after impact with the square and hemispherical indenters of the GFRP sandwich and the plain laminate differed significantly, by 19.29% and 43.33%, respectively, while a minimal difference of 3.5% was recorded for the conical indenter. Additionally, the results obtained with the clustering technique applied to the acoustic emission signals detected the main damaged modes, such as matrix cracking, fibre/matrix debonding, delamination, the debonding of face sheets/core, and core failure. The results therefore could provide a methodology for the optimisation and prediction of damage for the health monitoring of composites.
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Bone drilling is a universal procedure in orthopaedics for fracture fixation, installing implants, or reconstructive surgery. Surgical drills are subjected to wear caused by their repeated use, thermal fatigue, irrigation with saline solution, and sterilization process. Wear of the cutting edges of a drill bit (worn drill) is detrimental for bone tissues and can seriously affect its performance. The aim of this study is to move closer to minimally invasive surgical procedures in bones by investigating the effect of wear of surgical drill bits on their performance. The surface quality of the drill was found to influence the bone temperature, the axial force, the torque and the extent of biological damage around the drilling region. Worn drill produced heat above the threshold level related to thermal necrosis at a depth equal to the wall thickness of an adult human bone. Statistical analysis showed that a sharp drill bit, in combination with a medium drilling speed and drilling at shallow depth, was favourable for safe drilling in bone. This study also suggests the further research on establishing a relationship between surface integrity of a surgical drill bit and irreversible damage that it can induce in delicate tissues of bone using different drill sizes as well as drilling parameters and conditions.
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Osso e Ossos , Temperatura Alta , Humanos , Desenho de Equipamento , Osso e Ossos/cirurgia , Temperatura , OsteotomiaRESUMO
A prosthesis is loaded by forces and torques exerted by its wearer, the amputee, and should withstand instances of peak loads without failure. Traditionally, strong prosthetic sockets were made using a composite with a variety of reinforcing fibres, such as glass, carbon, and Kevlar. Amputees in less-resourced nations can lack access to composite prosthetic sockets due to their unavailability or prohibitive cost. Therefore, this study investigates the feasibility of polyethylene terephthalate (PET) fibre-reinforced composites as a low-cost sustainable composite for producing functional lower-limb prosthetic sockets. Two types of these composites were manufactured using woven and knitted fabric with a vacuum-assisted resin transfer moulding (VARTM) process. For direct comparison purposes, traditional prosthetic-socket materials were also manufactured from laminated composite (glass-fibre-reinforced (GFRP)), monolithic thermoplastic (polypropylene (PP) and high-density polyethylene (HDPE)) were also manufactured. Dog-bone-shaped specimens were cut from flat laminates and monolithic thermoplastic to evaluate their mechanical properties following ASTM standards. The mechanical properties of PET-woven and PET-knitted composites were found to have demonstrated to be considerably superior to those of traditional socket materials, such as PP and HDPE. All the materials were also tested in the socket form using a bespoke test rig reproducing forefoot loading according to the ISO standard 10328. The static structural test of sockets revealed that all met the target load-bearing capacity of 125 kg. Like GFRP, the PETW and PETK sockets demonstrated higher deformation and stiffness resistance than their monolithic counterparts made from PP and HDPE. As a result, it was concluded that the PET-based composite could replace monolithic socket materials in producing durable and affordable prostheses.
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Understanding the mechanism of crack propagation during bone cutting is necessary for the development of realistic bone cutting models. This article studies the on-line fractural behaviour of cortical bone caused by penetration with a sharp metallic wedge mounted on an on-line loading stage within an X-ray microfocus computed tomography system. The experimental results demonstrated anisotropy in crack propagation depending on the penetration direction with regard to the longitudinal bone axis and relate the crack growth to the extent of penetration. Scanning electron microscopy is performed to analyse the mechanism of cracking in the two phase microstructure of compact bone.
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Fêmur/cirurgia , Fêmur/ultraestrutura , Modelos Biológicos , Animais , Bovinos , Fêmur/diagnóstico por imagem , Técnicas In Vitro , RadiografiaRESUMO
Adaptation is the process by which bone responds to changes in loading environment and modulates its properties and spatial organization to meet the mechanical demands. Adaptation in trabecular bone is achieved through increase in bone mass and alignment of trabecular-bone morphology along the loading direction. This transformation of internal microstructure is governed by mechanical stimuli sensed by mechanosensory cells in the bone matrix. Realisation of adaptation in the form of local bone-resorption and -formation activities as a function of mechanical stimuli is still debated. In silico modelling is a useful tool for simulation of various scenarios that cannot be investigated in vivo and particularly well suited for prediction of trabecular bone adaptation. This progress report presents the recent advances in in silico modelling of mechanoregulated adaptation at the scale of trabecular bone tissue. Four well-established bone-adaptation models are reviewed in terms of their recent improvements and validation. They consider various mechanical factors: (i) strain energy density, (ii) strain and damage, (iii) stress nonuniformity and (iv) daily stress. Contradictions of these models are discussed and their ability to describe adequately a real-life mechanoregulation process in bone is compared.
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Collagen is the basic protein of animal tissues and has a complex hierarchical structure. It plays a crucial role in maintaining the mechanical and structural stability of biological tissues. Over the years, it has become a material of interest in the biomedical industries thanks to its excellent biocompatibility and biodegradability and low antigenicity. Despite its significance, the mechanical properties and performance of pure collagen have been never reviewed. In this work, the emphasis is on the mechanics of collagen at different hierarchical levels and its long-term mechanical performance. In addition, the effect of hydration, important for various applications, was considered throughout the study because of its dramatic influence on the mechanics of collagen. Furthermore, the discrepancies in reports of the mechanical properties of collagenous tissues (basically composed of 20-30% collagen fibres) and those of pure collagen are discussed.