RESUMO
In recent years, there has been a growing interest in developing smart drug delivery systems based on natural resources combined with stimulus-sensitive elements. This trend aims to formulate innovative and sustainable delivery platforms tailored for topical applications. This work proposed the use of layer-by-layer (LbL) methodology to fabricate biocompatible photo-responsive multilayer systems. These systems are composed of a polyoxometalate inorganic salt (POM) ([NaP5W30O110]14-) and a natural origin polymer, chitosan (CHT). Curcumin (CUR), a natural bioactive compound, was incorporated to enhance the functionality of these systems during the formation of hollow capsules. The capsules produced, with sizes between 2-5µm (SEM), were further dispersed into CHT/VCO (virgin coconut oil) emulsion solutions that were casted into molds and dried at 37 °C for 48 h. The system presented a higher water uptake in PBS than in acidic conditions, still significantly lower than that earlier reported to other CHT/VCO-based systems. The drug release profile is not significantly influenced by the medium pH reaching a maximum of 37% ± 1% after 48 h. The antioxidant performance of the designed structures was further studied, suggesting a synergistic beneficial effect resulting from CUR, POM, and VCO individual bioactivities. The increased amount of those excipients released to the media over time promoted an increase in the antioxidant activity of the system, reaching a maximum of 38.1% ± 0.1% after 48 h. This work represents a promising step towards developing advanced, sustainable drug delivery systems for topical applications.
RESUMO
Apresenta diferentes concepções em torno dos êxtases de uma beata (Irmã Germana) que viveu em Minas Gerais no século XIX, o parecer do médico Antônio Gonçalves Gomide, seguido do exame de dois cirurgiões e da narrativa do naturalista Auguste de Saint-Hilaire. O objetivo é situar historicamente os textos, investigando as orientações teóricas dos autores e o modo como analisaram os êxtases da beata. A publicação dos documentos pode contribuir para o estudo dos saberes médico-mentais em inícios do século XIX no Brasil.
The article presents two different views of the ecstasies of a nun (Sister Germana) who lived in Minas Gerais, Brazil, in the nineteenth century. The first perspective was the opinion of Dr. Antônio Gonçalves Gomide, together with an examination by two surgeons; the second was a narrative by the naturalist Auguste de Saint-Hilaire. The goal is to historically situate the texts, investigate the theoretical orientations of the authors and note how they analyzed the woman's moments of ecstasy. The publication of these texts contributed to the study of medical and mental knowledge in the early 19th century in Brazil.
Cet article présente les différents aspects de l'extase d'une religieuse (la Sur Germana) qui a vécu dans l'État de Minas Gerais au XIXe siècle, l'avis de son médecin Antonio Gonçalves Gomide, suivi de l'examen de deux chirurgiens et le récit du naturaliste Auguste de Saint-Hilaire. Notre travail est de situer historiquement les textes, d'enquêter sur les orientations théoriques des auteurs et sur la façon dont ils ont analysé l'extase de la sainte. Cet article a comme but de contribuer à l'étude des connaissances médicales et mentales au Brésil au début du XIXe siècle.
Se presentan diferentes concepciones acerca de los éxtasis de una beata (Sor Germana) que vivió en Minas Gerais en el siglo XIX, la opinión del médico Antônio Gonçalves Gomide, seguido por el examen de dos cirujanos y la narrativa del naturalista Auguste de Saint-Hilaire. El objetivo es situar históricamente los textos, investigando las orientaciones teóricas de los autores y el modo como analizaron los éxtasis de la beata. La publicación de los documentos puede contribuir para el estudio de los saberes médico-mentales en los inicios del siglo XIX en Brasil.