Detalhe da pesquisa
1.
Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry
; 55(9): 1384-97, 2016 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26854536
2.
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Mol Oncol
; 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38506049
3.
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J Med Chem
; 61(6): 2533-2551, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29485874
4.
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
ACS Chem Biol
; 12(8): 1986-1992, 2017 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679043
5.
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
PLoS One
; 10(6): e0131507, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26121039
6.
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
Structure
; 22(5): 744-55, 2014 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24704254