Detalhe da pesquisa
1.
Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response.
Clin Exp Immunol
; 210(2): 141-150, 2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36124688
2.
Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.
J Allergy Clin Immunol
; 143(4): 1549-1559.e6, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30092288
3.
Janus kinases to jakinibs: from basic insights to clinical practice.
Rheumatology (Oxford)
; 58(Suppl 1): i4-i16, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30806710
4.
The regulation of JAKs in cytokine signaling and its breakdown in disease.
Cytokine
; 118: 48-63, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29685781
5.
Aiming for the pocket.
Nat Chem Biol
; 18(12): 1296-1297, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36097296
6.
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Clin Exp Rheumatol
; 36 Suppl 112(3): 47-50, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29465367
7.
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.
Proc Natl Acad Sci U S A
; 112(15): 4642-7, 2015 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25825724
8.
Molecular insights into regulation of JAK2 in myeloproliferative neoplasms.
Blood
; 125(22): 3388-92, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25824690
9.
Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
J Biol Chem
; 290(45): 27261-27270, 2015 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26359499
10.
Tudor staphylococcal nuclease (Tudor-SN), a novel regulator facilitating G1/S phase transition, acting as a co-activator of E2F-1 in cell cycle regulation.
J Biol Chem
; 290(11): 7208-20, 2015 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25627688
11.
Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome.
Clin Immunol
; 165: 60-7, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26995659
12.
Tudor-SN, a novel coactivator of peroxisome proliferator-activated receptor γ protein, is essential for adipogenesis.
J Biol Chem
; 289(12): 8364-74, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24523408
13.
The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.
Biochim Biophys Acta
; 1844(10): 1835-41, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25107665
14.
The activity of JAK-STAT pathways in rheumatoid arthritis: constitutive activation of STAT3 correlates with interleukin 6 levels.
Rheumatology (Oxford)
; 54(6): 1103-13, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25406356
15.
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
Biochem J
; 458(2): 395-405, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24354892
16.
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Biochem J
; 457(2): 323-34, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24107129
17.
Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2.
J Immunol
; 188(3): 1011-8, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22219326
18.
Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.
Sci Adv
; 10(10): eadl2097, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38457493
19.
Tudor staphylococcal nuclease (Tudor-SN) participates in small ribonucleoprotein (snRNP) assembly via interacting with symmetrically dimethylated Sm proteins.
J Biol Chem
; 287(22): 18130-41, 2012 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22493508
20.
New insights into the structure and function of the pseudokinase domain in JAK2.
Biochem Soc Trans
; 41(4): 1002-7, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23863170