Detalhe da pesquisa
1.
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins.
Nat Chem Biol
; 19(10): 1246-1255, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37592157
2.
Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors.
Angew Chem Int Ed Engl
; 62(21): e202301258, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36940280
3.
Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
Glycobiology
; 32(5): 429-440, 2022 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34939113
4.
Comparison of α2,6-sialyltransferases for sialylation of therapeutic proteins.
Glycobiology
; 29(10): 735-747, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31281932
5.
Directed evolution of bacterial polysialyltransferases.
Glycobiology
; 29(7): 588-598, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30976781
6.
Characterization of a thermostable endoglucanase from Cellulomonas fimi ATCC484.
Biochem Cell Biol
; 96(1): 68-76, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28982013
7.
Convergent evolution of polysaccharide debranching defines a common mechanism for starch accumulation in cyanobacteria and plants.
Plant Cell
; 25(10): 3961-75, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24163312
8.
Crystal structure of the Chlamydomonas starch debranching enzyme isoamylase ISA1 reveals insights into the mechanism of branch trimming and complex assembly.
J Biol Chem
; 289(33): 22991-23003, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24993830
9.
Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.
J Biol Chem
; 285(23): 17763-70, 2010 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356844
10.
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.
Bioorg Med Chem
; 19(13): 3929-34, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21669536
11.
Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen.
ACS Chem Biol
; 16(10): 2004-2015, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34309358
12.
7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins.
ACS Cent Sci
; 7(2): 345-354, 2021 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33655072
13.
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers.
Nat Biomed Eng
; 5(10): 1202-1216, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34373602
14.
New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.
Biochemistry
; 49(3): 443-51, 2010 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20039683
15.
Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.
Bioorg Med Chem
; 18(22): 7794-8, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20970346
16.
Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families.
Chemistry
; 15(7): 1627-36, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19123216
17.
A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans.
Cell Chem Biol
; 26(2): 203-212.e5, 2019 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30503285
18.
An enzymatic pathway in the human gut microbiome that converts A to universal O type blood.
Nat Microbiol
; 4(9): 1475-1485, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182795
19.
Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit.
J Nutr
; 138(4): 685-92, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18356321
20.
Studies directed toward the stereochemical structure determination of the naturally occurring glucosidase inhibitor, kotalanol: synthesis and inhibitory activities against human maltase glucoamylase of seven-carbon, chain-extended homologues of salacinol.
J Org Chem
; 73(16): 6172-81, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18651773