Complex apodized Bragg grating filters without circulators in silicon-on-insulator.

Bragg gratings operating in reflection are versatile filters that are an important building block of photonic circuits but, so far, their use has been limited due to the absence of CMOS compatible integrated circulators. In this paper, we propose to introduce two identical Bragg gratings in the arms of a Mach-Zehnder interferometer built with multimode interference 2 x 2 couplers to provide a reflective filter without circulator. We show that this structure has unique properties that significantly reduce phase noise distortions, avoid the need for thermal phase tuning, and make it compatible with complex apodization functions implemented through superposition apodization. We experimentally demonstrate several Bragg grating filters with high quality reflection spectra. For example, we successfully fabricated a 4 nm dispersion-less square-shaped filter having a sidelobe suppression ratio better than 15 dB and an in-band phase response with a group delay standard deviation of 2.0 ps. This result will enable the fabrication of grating based narrowband reflective filters having sharp spectral responses, which represents a major improvement in the filtering capability of the silicon platform.

Bandpass integrated Bragg gratings in silicon-on-insulator with well-controlled amplitude and phase responses.

Bandpass filters with square shape amplitude responses and well-controlled dispersion characteristics are achieved by accurate apodization of Bragg grating structures in silicon-on-insulator waveguides. For these devices, precise tailoring of their frequency response typically requires low coupling coefficients and relatively long on-chip propagation lengths. These challenges are addressed by implementing apodization by phase-modulation and using wider strip waveguides to reduce phase noise. This design approach is demonstrated with a dispersion-less narrowband filter and a chirped bandpass filter.

Multiwavelength super-structured Bragg grating laser for tunable repetition rate mode-locked operation.

A multiwavelength laser based on a super-structured Bragg grating is designed and fabricated on multiquantum well AlGaInAs-InP. This laser exhibits phase locking via mutual injection of the neighboring cavities assisted by four wave mixing. We present optical and electrical characterization of its emission regimes showing a complex dynamic behavior. More specifically, this paper focuses on a pulsed regime with a quasi-continuous tunable repetition rate from 32 GHz to 49 GHz.

Integrated Bragg gratings in spiral waveguides.

Over the last two decades, many filters requiring custom spectral responses were obtained from photo-inscribed fiber Bragg gratings because of the flexibility inherent to this technology. However, Bragg gratings in silicon waveguides have the potential to provide faster and more efficient tuning capabilities when compared to optical fiber devices. One drawback is that Bragg gratings filters with elaborate spectral amplitude and phase responses often require a long interaction length, which is not compatible with current integration trends in CMOS compatible photonic circuits. In this paper, we propose to make Bragg gratings in spiral-shaped waveguides in order to increase their lengths while making them more compact. The approach preserves the flexibility of regular straight grating structures. More specifically, we demonstrate 2-mm long gratings wrapped in an area of 200 µm x 190 µm without any spectral degradation due to waveguide curvature. Furthermore, we interleave three spiral waveguides with integrated gratings thereby tripling the density and demonstrate good phase compensation for each of them. Finally, we show that this approach is compatible with phase-apodization of the grating coupling coefficient.

Characterization and reduction of spectral distortions in silicon-on-insulator integrated Bragg gratings.

A major issue in the fabrication of integrated Bragg grating filters in highly confined waveguides is the average effective index fluctuations caused by waveguide dimension variations. Lateral variations are caused by the sidewall roughness created during the etching process while vertical variations are coming from the wafer silicon layer thickness non-uniformity. Grating spectral distortions are known to result solely from the low spatial frequency components of these variations. As a result, in this work, we present an experimental method to quantify such relevant spatial components by stitching a hundred high-resolution scanning electron microscope images. Additionally, we propose two techniques to reduce, in the design, the phase noise impact on integrated Bragg gratings without relying on fabrication process improvements. More specifically, we show that the use of hybrid multimode/singlemode waveguides reduce by more than one order of magnitude the effect of sidewall roughness on integrated Bragg gratings while we show that the fabrication of ultra-compact gratings in spiral waveguides mitigate the impact of the silicon layer thickness variations.

The Identification of Nuclear FMRP Isoform Iso6 Partners.

A deficiency of FMRP, a canonical RNA-binding protein, causes the development of Fragile X Syndrome (FXS), which is characterised by multiple phenotypes, including neurodevelopmental disorders, intellectual disability, and autism. Due to the alternative splicing of the encoding FMR1 gene, multiple FMRP isoforms are produced consisting of full-length predominantly cytoplasmic (i.e., iso1) isoforms involved in translation and truncated nuclear (i.e., iso6) isoforms with orphan functions. However, we recently implicated nuclear FMRP isoforms in DNA damage response, showing that they negatively regulate the accumulation of anaphase DNA genomic instability bridges. This finding provided evidence that the cytoplasmic and nuclear functions of FMRP are uncoupled played by respective cytoplasmic and nuclear isoforms, potentially involving specific interactions. While interaction partners of cytoplasmic FMRP have been reported, the identity of nuclear FMRP isoform partners remains to be established. Using affinity purification coupled with mass spectrometry, we mapped the nuclear interactome of the FMRP isoform iso6 in U2OS. In doing so, we found FMRP nuclear interaction partners to be involved in RNA processing, pre-mRNA splicing, ribosome biogenesis, DNA replication and damage response, chromatin remodeling and chromosome segregation. By comparing interactions between nuclear iso6 and cytoplasmic iso1, we report a set of partners that bind specifically to the nuclear isoforms, mainly proteins involved in DNA-associated processes and proteasomal proteins, which is consistent with our finding that proteasome targets the nuclear FMRP iso6. The specific interactions with the nuclear isoform 6 are regulated by replication stress, while those with the cytoplasmic isoform 1 are largely insensitive to such stress, further supporting a specific role of nuclear isoforms in DNA damage response induced by replicative stress, potentially regulated by the proteasome.