Detalhe da pesquisa
1.
The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.
Cell
; 165(7): 1632-1643, 2016 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27315480
2.
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Mol Cell
; 58(6): 1040-52, 2015 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25982113
3.
Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease.
Respir Res
; 23(1): 183, 2022 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35831901
4.
Functional characterisation of G protein-coupled receptors.
Methods
; 147: 213-220, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29510249
5.
The Structure of the CGRP and Related Receptors.
Handb Exp Pharmacol
; 255: 23-36, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-29797088
6.
Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex.
Biochemistry
; 57(32): 4915-4922, 2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004692
7.
Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.
PLoS Comput Biol
; 13(11): e1005819, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29131821
8.
Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP8-37): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.
Biochemistry
; 56(30): 3877-3880, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28691801
9.
A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.
Mol Pharmacol
; 89(3): 335-47, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700562
10.
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations.
Proc Natl Acad Sci U S A
; 110(13): 5211-6, 2013 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23479653
11.
Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
J Pharmacol Exp Ther
; 353(1): 52-63, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25630467
12.
Classifying tetraspanins: A universal system for numbering residues and a proposal for naming structural motifs and subfamilies.
Biochim Biophys Acta Biomembr
; 1866(3): 184265, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38154528
13.
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
J Biol Chem
; 287(6): 3659-73, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22147709
14.
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
J Biol Chem
; 287(6): 3642-58, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22147710
15.
Structure-function studies of muscarinic acetylcholine receptors.
Handb Exp Pharmacol
; (208): 29-48, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22222693
16.
RAMPs and CGRP receptors.
Adv Exp Med Biol
; 744: 13-24, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22434104
17.
RAMPs as drug targets.
Adv Exp Med Biol
; 744: 61-74, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22434108
18.
Membrane Protein Production in the Yeast P. pastoris.
Methods Mol Biol
; 2507: 187-199, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35773583
19.
Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.
Mol Pharmacol
; 80(3): 486-97, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21616920
20.
Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids.
J Pharmacol Exp Ther
; 336(2): 540-50, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21075839