Detalhe da pesquisa
1.
Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial.
Am J Respir Crit Care Med
; 205(10): 1228-1235, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35258443
2.
Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data.
J Infect Dis
; 225(11): 1876-1885, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33606880
3.
Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model.
J Infect Dis
; 224(6): 1039-1047, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33502537
4.
Rifampicin Can Be Given as Flat-Dosing Instead of Weight-Band Dosing.
Clin Infect Dis
; 71(12): 3055-3060, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31867594
5.
Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32122887
6.
Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis.
Haemophilia
; 26(1): 164-172, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31797491
7.
A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.
J Pharmacokinet Pharmacodyn
; 47(5): 421-430, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32488575
8.
Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358585
9.
Individualised dosing algorithm and personalised treatment of high-dose rifampicin for tuberculosis.
Br J Clin Pharmacol
; 85(10): 2341-2350, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31269277
10.
Evaluation of critical parameters in the hollow-fibre system for tuberculosis: A case study of moxifloxacin.
Br J Clin Pharmacol
; 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38632083
11.
Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations.
J Infect Dis
; 218(6): 991-999, 2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29718390
12.
The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis.
Clin Infect Dis
; 67(1): 34-41, 2018 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29917079
13.
A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations.
J Antimicrob Chemother
; 73(2): 437-447, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29136155
14.
Distribution of plasma concentrations of first-line anti-TB drugs and individual MICs: a prospective cohort study in a low endemic setting.
J Antimicrob Chemother
; 73(10): 2838-2845, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30124844
15.
Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods.
J Antimicrob Chemother
; 72(8): 2311-2319, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28520930
16.
Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches.
J Pharmacokinet Pharmacodyn
; 44(4): 325-333, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28389762
17.
Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.
Eur Respir J
; 57(3)2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33154028
18.
A multistate tuberculosis pharmacometric model: a framework for studying anti-tubercular drug effects in vitro.
J Antimicrob Chemother
; 71(4): 964-74, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26702921
19.
A Pharmacokinetic-Pharmacodynamic Model of Morphine Exposure and Subsequent Morphine Consumption in Postoperative Pain.
Pharm Res
; 33(5): 1093-103, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26753622
20.
Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain.
Anesthesiology
; 123(6): 1411-9, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26495978