Use of adrenaline and atropine in neonatal resuscitation.

One hundred and five infants treated with adrenaline or atropine, or both, as part of resuscitation on 124 occasions were studied retrospectively. Adrenaline was administered to 98 infants, in 40 of whom it was in combination with atropine, and seven infants received atropine alone. Twenty infants were treated solely on the delivery unit, 81 on the neonatal medical unit, and four in both places. Twelve infants treated on the delivery unit and 13 treated on the neonatal unit survived. Follow up studies showed that 13 infants were handicapped with nine severely handicapped. Extreme prematurity, the need for early or repeated resuscitation using these drugs, particularly for episodes of collapse without a clear precipitating cause, and asystole rather than bradycardia were associated with a worse outcome. Evidence is accumulating to support a view that the use of these drugs for resuscitation at birth and in the first week of life of extremely preterm infants may be inappropriate.

Increased survival and deteriorating developmental outcome in 23 to 25 week old gestation infants, 1990-4 compared with 1984-9.

AIMS: To assess whether changes in survival over time in infants of 23 to 25 weeks of gestational age were accompanied by changes in the incidence of disability in childhood during an 11 year period. METHODS: Obstetric and neonatal variables having the strongest association with both survival to discharge from a regional neonatal medical unit and neurodevelopmental disability in 192 infants of 23 to 25 weeks of gestation, born in 1984 to 1994, were studied as a group and in two cohorts (1984 to 1989 n = 96 and 1990 to 1994 n = 96). The data collected included CRIB (clinical risk index for babies) scores and cranial ultrasound scan findings. The children were followed up at outpatient clinics. RESULTS: Between 1984 and 1989 (cohort 1) and 1990 and 1994 (cohort 2) the rate of survival to discharge increased significantly from 27% to 42% and the rate of disability in survivors increased from 38% to 68%; most of this increase was in mild disability. The proportions of survivors with cerebral palsy did not alter significantly (21% vs 18%), but more survivors with blindness due to retinopathy of prematurity (4% vs 18%), myopia (4% vs 15%) and squints (8% vs 13%) contributed to the increased rate of disability. Clinically significant cranial ultrasound findings and a high CRIB score were strongly associated with death. A high CRIB score was most strongly associated with disability. CONCLUSIONS: The rise in disability with improved survival was not due to cerebral palsy; rather the main contributors were blindness due to retinopathy, myopia, and squint. The causes of these disabilities seem to be linked to high CRIB scores. A system of regular and skilled retinal examination and access to facilities for retinal ablation should be in place in all neonatal units which undertake the care of such extremely preterm infants.

Blood pressure, heart rate, and skin temperature in preterm infants: associations with periventricular haemorrhage.

The mean arterial blood pressure (MABP), heart rate, and skin temperature were monitored every 15 minutes in the first 10 days after birth in 34 preterm infants, gestational age 24 to 33 weeks. Ultrasound brain scans carried out daily showed that a periventricular haemorrhage (PVH) occurred in a subgroup of infants (n = 15) of lower birthweight and gestational age. In infants without PVH the daily median of MABP increased with birthweight and postnatal age; that of heart rate was not affected by postnatal age, body weight, or gestational age; and that of skin temperature showed a slight fall with postnatal age. In infants with PVH, on or before the day of PVH, daily medians of MABP and skin temperature were not significantly different from those of infants without PVH, but the daily median of heart rate tended to be slightly higher. The percentage of positive correlations between the 96 15 minute values per day for heart rate and MABP increased with postnatal age and with birthweight, but did not differ in infants who developed a PVH. The coefficient of variation (CV) of the 96 15 minute values for MABP tended to be higher in infants on the day of PVH, and a similar trend was apparent on the day before. The processes of development of blood pressure, heart rate, and skin temperature are similar in infants with or without PVH but at lower gestational ages altered blood pressure control may cause brain haemorrhage.

Developmental delay in congenital myotonic dystrophy after neonatal intensive care.

Six infants with congenital myotonic dystrophy survived after neonatal intensive care. In later childhood they were assessed by the Griffiths Mental Development Scales: five children were functioning in the mildly handicapped to borderline range of development (DQ 64.0 to 79.0) and the remaining child was severely delayed in development (DQ 33.0). The five children with higher DQ values had a history of ventilatory support of 30 days or less after birth. By contrast, the remaining child with the lowest DQ value had been ventilated for 43 days. This study provides further evidence that prolonged ventilation after birth has prognostic significance in identifying severely affected cases with congenital myotonic dystrophy.

Methadone-exposed newborn infants: outcome after alterations to a service for mothers and infants.

OBJECTIVE: To evaluate the impact of a shared care approach in clinical management with a drug liaison midwife (DLM) service for mothers and infants established in 1995-1996 in an inner city area and to address the problem of congenital abnormality and microcephaly with fetal drug exposure. METHODS: Descriptive analysis of data in live births of women enrolled in a methadone maintenance programme in 1991-1994 (n = 78) and 1997-2001 (n = 98), including time spent in hospital, treatment for neonatal abstinence syndrome (NAS), admission to the neonatal medical unit (NMU) and follow-up for child health checks. RESULTS: In 1997-2001 compared with 1991-1994, the mothers used more methadone in the last week of pregnancy (median 40.0 mg/day vs. 21.5 mg/day, P = 0.0006) and there were more preterm deliveries (36% vs. 21%, P = 0.03). The infants spent less time in hospital (median 5 days vs. 28 days, P < 0.0001), a smaller proportion had treatment for NAS (14% vs. 79%, P < 0.0001), and NMU admission was reduced (median 14 days vs. 26 days, P < 0.0003). Neonatal convulsions (P = 0.0001) and jaundice (P < 0.001) occurred less frequently, and more infants were breastfed (P = 0.001). One infant in each study group had a cleft palate and none had microcephaly. Child health checks for 18-24 months showed a favourable outcome in 1997-2001. CONCLUSIONS: We altered antenatal care and modified neonatal management, subsequently infants spent less time in hospital and NMU admissions were reduced with less NAS treatment. Congenital abnormalities and microcephaly were not common and as regular child health checks were possible, the impact of the DLM service in shared management merits further investigation, for mother-infant bonding and developmental outcome.

A two year prospective study of hospital-acquired respiratory virus infection on paediatric wards.

Over a 24 month period on six paediatric wards of different designs 169 cases of possible hospital-acquired respiratory virus infection were investigated. A variety of viruses was isolated from 82 cases, the most common being respiratory syncytial virus, influenza, parainfluenza, adenoviruses and rhinoviruses. A further 73 children developed respiratory symptoms between 3 and 300 days after administration but viruses were not demonstrable by the techniques used. These children were thought to have hospital-acquired infection nonetheless. Thirteen children were shown not to have acquired infection as the cause of their intercurrent illness. Most acquired infections occurred where toddlers were in cots in open wards. Children with trauma, including non-accidental injury, congenital malformations, mental retardation, failure to thrive or neoplasia were most likely to become infected. Almost 20% of children suffered from croup or lower respiratory tract illness as a result of their acquired infection. The figure was 41% if those less than 12 months old were considered alone. Most episodes settled quickly but in a few children investigations or surgery were delayed for a few days.

Histiocytosis X; follow-up of 43 cases.

Over a 29-year period, 43 cases of histiocytosis X presented in children under the age of 12 years. 29 patients (67%) have survived, and of these, 15 (52%) have a detectable disability. It was confirmed that young age at presentation and evidence of soft tissue involvement were associated with a worse prognosis. The majority of deaths were associated with pulmonary involvement. 14 patients developed diabetes insipidus. 5 of the surviving adults have heights below the 3rd centile. Puberty usually occurred at a normal age. Follow-up studies on 12 survivors showed no evidence of residual abnormality of haematology, deficient lymphocyte function, or yeast opsonization. HLA typing showed no unusual pattern. Mild carbon monoxide diffusion deffects were present in 4 patients and other abnormalities were detected on lung function tests.

Treatment of renal failure in neonates.

Thirty neonates with acute renal failure were studied, 27 of whom died (90%) including nine of 12 treated by peritoneal dialysis. Three main aetiological groups were identified. Septicaemia was a principal cause of late onset acute renal failure, with an incidence equal to that of serious perinatal disorders. It is recommended that tolazoline should be used with caution in the treatment of hyperkalaemia as it may have a role in the aetiology of acute renal failure, the incidence of which is increasing.

Visual evoked-response components related to speechreading and spatial skills in hearing and hearing-impaired adults.

Averaged visual evoked responses (VER) to light flashes which varied systematically in brightness and predictability were collected from 24 hearing and 24 hearing-impaired adults. In addition, speechreading, abstract reasoning, and spatial relations tests were administered. Separate principal components analyses of the VERs were conducted on each group to replicate and extend our previous report of an early VER component (VF16) which reflected individual differences in the speechreading skills of hearing subjects. VF16 appeared in both analyses, confirming its replicability as a latent VER component. VF16 correlated with speechreading skill in hearing-impaired males (r = -.73), under stimulus conditions identical to those in our previous study. However, its correlations with speechreading skills in hearing subjects were not significant. VF16 also varied systematically with stimulus predictability and correlated with spatial ability in both groups only when the time of occurrence of the light flashes was predictable. These data tentatively suggest that VF16 is a VER correlate of individual differences in a psychologically dynamic process, perhaps involving expectancy, which may relate to the performance of hearing-impaired and hearing people in visually based communication or cognitive processing situations.

Visual evoked-response correlates of speechreading performance in normal-hearing adults: a replication and factor analytic extension.

The relationship between the latency of the negative peak occurring at approximately 130 msec in the visual evoked-response (VER) and speechreading scores was investigated. A significant product-moment correlation of -.58 was obtained between the two measures, which confirmed the fundamental effect but was significantly weaker than that previously reported in the literature (-.90). Principal components analysis of the visual evoked-response waveforms revealed a previously undiscovered early VER component, statistically independent of the latency measure, which in combination with two other components predicted speechreading with a multiple correlation coefficient of .84. The potential significance of this new component for the study of individual differences in speechreading ability is discussed.

Congenital midline scalp and skull defect.

A family with multiple congenital scalp defects, over two generations and probably genetically determined, is described. Although alarming in appearance, surgical intervention is not indicated at least for small lesions. The risk of haemorrhage and meningitis is emphasized.

Echovirus 19 infection in infants under six months.

Twenty-four infants under 6 months infected with echovirus 19 are described, They were the youngest of the many children admitted to hospitals in Newcastle and Gateshead during an epidemic in the north-east of England in 1974. Generally, the younger the child the more severe the illness, which affected the upper respiratory tract, the gut, the skin, and the meninges, and sometimes caused as state of collapse resembling septicaemic shock. Polymorphonuclear pleocystosis of the cerebrospinal fluid (CSF) sometimes suggested bacterial meningitis, so that antibiotics were given in 38% of cases. The virus was recovered with a high success rate from nasopharyngeal secretions, CSF, and stool.

Referrals to a regional neonatal intensive care unit.

Over a three year period 444 requests for the neonatal transfer of babies with acute medical problems were received at this regional neonatal medical unit. Despite an increase in available resources in the North Western Health Region the provision of intensive care remained inadequate with 38% of requests declined, and babies had to be referred elsewhere including to neighbouring health regions. The survival of those babies who had to remain at the hospital of birth (49%) was significantly lower than for those transferred to the regional centre (71%). Those babies declined admission had significantly lower gestational ages and birth weights than those accepted. For those babies with respiratory failure and birth weights of less than 1500 g within these two groups, however, there were no significant differences in birth weight, gestational age, or gender yet survival was significantly better for those transferred. Babies from multiple pregnancies caused particular problems if neonatal transfer was required.

Outcome for newborn babies declined admission to a regional neonatal intensive care unit.

Between July 1979 and June 1980 the regional neonatal intensive care unit (NICU) at St Mary's Hospital, Manchester, received 170 requests from maternity units for the transfer of ill newborn babies. Most of the babies were suffering from respiratory failure. The initial request was declined in 65 babies because of overcrowding or lack of facilities at the NICU (n = 59), or because transfer was not justified on medical grounds (n = 6). Forty-two of the 65 babies were compelled to remain in the maternity unit because they could not be accommodated at hospitals with facilities for ventilating newborn babies. The neonatal survival rate of babies with respiratory failure who were transferred to the NICU was 66% whereas the survival rate of similar babies who were declined transfer was 30%. Our findings support the efficacy of intensive care for ill babies with respiratory failure and suggest that such facilities need to be more widely developed.

Family implications of neonatal Gorlin's syndrome.

Two very preterm infants (born at 29 and 25 weeks, respectively) were found to have abnormal ribs. Though this was thought unimportant at the time, it was subsequently shown to indicate that some members of their families had a dominantly inherited risk of developing skin cancer and other serious problems.

Gastrointestinal blood flow velocity after the first feed.

Twenty preterm infants (gestational age range 27-36 weeks) who had never been fed enterally were studied. Doppler indices of flow velocity from the superior mesenteric and coeliac arteries were measured immediately before, and at postprandial time intervals up to 60 minutes after, a first feed of 1 ml of milk given through a nasogastric tube. There were no significant differences between the preprandial and postprandial values of blood pressure, heart rate, oxygen and carbon dioxide tensions, and pH. The median peak systolic velocity (PSV) (55.9 cm/sec) and time average mean velocity (TAV) (10.6 cm/sec) before the feed at the superior mesenteric artery rose progressively and significantly to postprandial peaks of 88.5 cm/sec and 20.5 cm/sec at 45 minutes, respectively. Significant postprandial rises in the median PSV and TAV values at the coeliac artery were also observed, with a peak at 45 minutes. There were no significant correlations between blood flow velocity indices (preprandial or postprandial) and gestational age, postnatal age, conceptional age, or birth weight. We conclude that the first exposure of preterm babies to a small volume of milk feed is associated with postprandial changes in blood flow velocity consistent with an increase in blood flow in the superior mesenteric and coeliac arteries, although the mechanism of this response is uncertain.

Linking visual and kinesthetic imagery in lipreading instruction.

The purpose of this study was to replicate van Uden's (1983) finding that watching oneself speak improves lipreading of visually confusable nonsense words. Specifically, this replication focused on an older group of subjects whose educational experience varied widely in the emphasis given to spoken communication. Four groups of 12 young-adult subjects who are deaf participated in evaluating two aspects of training: (a) source of video feedback (self or trainer), and (b) timing of feedback (during speech production or after speech production). Mean posttest results indicated significantly increased accuracy in identifying items that had been trained. The group that viewed self-speech after speech-production practice also demonstrated generalization to test items that were not trained. On the combined list of both trained and untrained items, both groups that viewed their own speech achieved significant gains compared to pretest scores, but those that viewed the trainer's speech did not. Response time (RT) during pre- and posttesting was measured using a computer-generated waveform display to calculate the interval between stimulus offset and response onset. Results are reported for 13 subjects with > or = 50% speech intelligibility for words in sentences. Although there were no differences attributable to training conditions, there was an overall increase in the regularity of the identification responses after training (measured by the standard deviation of RTs) and a generalization of the improvement to the untrained items. The results of this study substantiate the beneficial effects of multisensory feedback by practicing lipreading of one's own speech production. This finding appears to apply even to young-adult subjects who are deaf and whose habituated speech patterns may be quite distinct from those of talkers with normal hearing.

Multiple major cerebral artery thromboses with profound thrombocytopenia in acute leukaemia.

A child with acute lymphoblastic leukaemia complicated by prolonged gastrointestinal and skin haemorrhages due to profound thrombocytopenia finally died of thrombotic occlusions of major cerebral arteries due to mucormycosis. Biopsy of any suspect lesion is needed urgently before prolonged therapy with amphotericin B is started. So far there have been no cures in childhood.