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1.
Sensors (Basel) ; 24(14)2024 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-39065855

RESUMO

Defects on horizontal axis wind turbine blades are difficult to identify and monitor with conventional forms of non-destructive examination due to the blade's large size and limited accessibility during continuous operation. This article examines both strain and acceleration transmissibility as methods of continuous damage detection on wind turbine blades. A scaled 117 cm offshore wind turbine blade was first designed, 3D printed, and modelled numerically in ANSYS. Transverse cracks were deliberately introduced to the blade at 10 cm intervals along its leading edge. Subsequent changes in the transmissibility, relative to an undamaged baseline model, were measured using different variable combinations at the blade's first three natural frequencies. Experimental results indicated that strain transmissibility was able to locate a 1.0 cm defect at a range of 70-110 cm from the blade hub using the amplitudes of the first natural frequency of vibration. The numerical model was able to simulate the strain experimental results and was determined to be valid for future defect characterization. Acceleration transmissibility was unable to experimentally identify defects sized at 1.0 cm and below but was able to identify 1.0 cm sized defects numerically. It was concluded that transmissibility is viable for continuous damage detection on blades but that further research into other defect types and locations is required prior to conducting full-scale testing.

2.
Conserv Biol ; 35(6): 1882-1893, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-33728690

RESUMO

There has been much recent interest in the concept of rewilding as a tool for nature conservation, but also confusion over the idea, which has limited its utility. We developed a unifying definition and 10 guiding principles for rewilding through a survey of 59 rewilding experts, a summary of key organizations' rewilding visions, and workshops involving over 100 participants from around the world. The guiding principles convey that rewilding exits on a continuum of scale, connectivity, and level of human influence and aims to restore ecosystem structure and functions to achieve a self-sustaining autonomous nature. These principles clarify the concept of rewilding and improve its effectiveness as a tool to achieve global conservation targets, including those of the UN Decade on Ecosystem Restoration and post-2020 Global Biodiversity Framework. Finally, we suggest differences in rewilding perspectives lie largely in the extent to which it is seen as achievable and in specific interventions. An understanding of the context of rewilding projects is the key to success, and careful site-specific interpretations will help achieve the aims of rewilding.


Recientemente ha habido mucho interés por el concepto de retorno a la vida silvestre como herramienta para la conservación de la naturaleza, pero también ha habido confusión por la idea que ha limitado su utilidad. Desarrollamos una definición unificadora y diez principios básicos para el retorno a la vida silvestre por medio de encuestas a 59 expertos en retorno a la vida silvestre, un resumen de las visiones de las organizaciones más importantes para el retorno a la vida silvestre y talleres que involucraron a más de 100 participantes de todo el mundo. Los principios básicos transmiten que el retorno a la vida silvestre existe en un continuo de escala, conectividad y nivel de influencia humana y que su objetivo es restaurar la estructura y las funciones del ecosistema para lograr una naturaleza autónoma autosustentable. Estos principios aclaran el concepto del retorno a la vida silvestre e incrementan su efectividad como herramienta para lograr los objetivos mundiales de conservación, incluyendo aquellos de la Década de la ONU para la Restauración de Ecosistemas y el Marco de Trabajo de la Biodiversidad Global post 2020. Finalmente, sugerimos que las diferencias en las perspectivas del retorno a la vida silvestre yacen principalmente en el grado al que es visto como factible y en intervenciones específicas. Un entendimiento del contexto de los proyectos de retorno a la vida silvestre es importante para el éxito, y las interpretaciones específicas de sitio ayudarán a lograr las metas del retorno a la vida silvestre. Principios Básicos para el Retorno a la Vida Silvestre.


Assuntos
Conservação dos Recursos Naturais , Ecossistema , Biodiversidade , Humanos
3.
Sensors (Basel) ; 21(22)2021 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-34833773

RESUMO

The periodic permanent magnet electromagnetic acoustic transducer (PPM EMAT) is a sensor that can generate and receive shear horizontal (SH) waves without direct contact with the inspected medium using the Lorentz mechanism. However, the PPM EMAT experiences high signal variance on ferromagnetic steel under specific conditions, such as a change in signal amplitude when the sensor is moved in the direction of SH wave propagation. Magnetostriction effects are hypothesized to be the cause of these anomalous behaviors; the objective of this paper is to determine the relative strengths of the magnetostriction and Lorentz wave generation mechanisms for this type of EMAT on steel. This goal is accomplished through the use of a second EMAT, which induces only magnetostriction (MS-EMAT), to calibrate a novel semi-empirical magnetostriction model. It is found that magnetostriction effects reduce the amplitude of the SH wave generated by this particular PPM EMAT transmitter by an average of 29% over a range of input currents. It is also determined that magnetostriction is significant only in the investigated PPM EMAT transmitter, not the receiver. In terms of practical application, it is shown that the MS-EMAT is less sensitive to changes in the static and dynamic fields than PPM EMATs at specific operating points; this makes the MS-EMAT a viable alternative for nondestructive evaluation despite lower amplitudes.

4.
Sensors (Basel) ; 20(2)2020 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-31947518

RESUMO

In this special issue of Sensors, seven peer-reviewed manuscripts appear on the topic of ultrasonic transducer design and operation in harsh environments: elevated temperature, high gamma and neutron fields, or the presence of chemically aggressive species. Motivations for these research and development projects are strongly focused on nuclear power plant inspections (particularly liquid-sodium cooled reactors), and nondestructive testing of high-temperature piping installations. It is anticipated that we may eventually see extensive use of permanently mounted robust transducers for in-service monitoring of petrochemical plants and power generations stations; quality control in manufacturing plants; and primary and secondary process monitoring in the fabrication of engineering materials.

5.
Sensors (Basel) ; 19(24)2019 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-31817602

RESUMO

The viability for dry coupling of piezoelectric ultrasonic transducer components was investigated, using a thin foil of annealed silver as a filler material/coupling agent at each component interface. Criteria used for room temperature evaluation were centered on signal-to-noise ratio (SNR) and echo bandwidth, for a Li-Nb based transducer operating in pulse-echo mode. A normal clamping stress of only 25 MPa, applied repeatedly over three loading cycles on a precisely-aligned transducer stack, was sufficient to yield backwall echoes with a SNR greater than 25 dB, and a 3 dB bandwidth of approximately 65%. This compares to a SNR of 32 dB and a 3 dB bandwidth of 65%, achievable when all transducer interfaces were coupled with ultrasonic gel. The respective roles of a soft filler material, alignment of transducer components, cyclic clamping, component roughness, and component flatness were evaluated in achieving this high efficiency dry coupling, with transducer clamping forces far lower than previously reported. Preliminary high temperature tests indicate that this coupling method is suitable for high temperature and achieves signal quality comparable to that at room temperature with ultrasonic gel.

6.
J Acoust Soc Am ; 136(3): 985, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25190374

RESUMO

The problem of elastic wave propagation in an infinite bar of arbitrary cross section is studied via a generalized version of the Fourier expansion collocation method. In the current formulation, the exact three dimensional solution to Navier's equation in cylindrical coordinates is used to obtain the boundary traction vector as a periodic, piecewise continuous/differentiable function of the angular coordinate. Traction free conditions are then met by setting the Fourier coefficients of the boundary traction vector to zero without approximating the bounding surface by multi-sided polygons as in the method presented by Nagaya. The method is derived for a general cross section with no axial planes of symmetry. Using the general formulation it is shown that the symmetric and asymmetric modes decouple for cross sections having one axial plane of symmetry. An efficient algorithm for computing dispersion curves based on the current method is presented and used to obtain the fundamental longitudinal and flexural wave speeds for a bar of elliptical cross section. The results are compared to those obtained by previous researchers using exact and approximate treatments.

7.
Nature ; 449(7165): 1041-3, 2007 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-17960242

RESUMO

Theoretical ecology is largely founded on the principle of mass action, in which uncoordinated populations of predators and prey move in a random and well-mixed fashion across a featureless landscape. The conceptual core of this body of theory is the functional response, predicting the rate of prey consumption by individual predators as a function of predator and/or prey densities. This assumption is seriously violated in many ecosystems in which predators and/or prey form social groups. Here we develop a new set of group-dependent functional responses to consider the ecological implications of sociality and apply the model to the Serengeti ecosystem. All of the prey species typically captured by Serengeti lions (Panthera leo) are gregarious, exhibiting nonlinear relationships between prey-group density and population density. The observed patterns of group formation profoundly reduce food intake rates below the levels expected under random mixing, having as strong an impact on intake rates as the seasonal migratory behaviour of the herbivores. A dynamical system model parameterized for the Serengeti ecosystem (using wildebeest (Connochaetes taurinus) as a well-studied example) shows that grouping strongly stabilizes interactions between lions and wildebeest. Our results suggest that social groups rather than individuals are the basic building blocks around which predator-prey interactions should be modelled and that group formation may provide the underlying stability of many ecosystems.


Assuntos
Cadeia Alimentar , Leões/fisiologia , Mamíferos/fisiologia , Comportamento Predatório/fisiologia , Comportamento Social , Animais , Biomassa , Processos Grupais , Modelos Biológicos , Densidade Demográfica , Fatores de Tempo
8.
IEEE Trans Biomed Eng ; 70(2): 544-552, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-35939463

RESUMO

OBJECTIVE: Background theory and a new algorithm for single-point adaptive focusing in transmission mode through ultrasonic barriers via one-dimensional phased arrays were reported in part I. In this paper the algorithm is further extended and implemented into a full adaptive beamforming process, including complete transmission and reception modes. METHODS: Corrected time delay patterns, adapted to the local acoustical and geometrical properties of the barrier, are calculated and applied in both modes. Further, an adaptive imaging process is also developed that implements the proposed beamforming process for two-dimensional imaging through randomly shaped multilayered phase-aberrating structures. The method is optimized for the case of human skull as the ultrasound barrier and its application for transcranial imaging is discussed. RESULTS: Laboratory results of adaptive imaging through realistic skull-mimicking phantoms are presented. The algorithms are implemented on a 64-channel ultrasound open-source phased array platform controlling a standard 128-element biomedical phased array. Irregularly shaped reflectors with characteristic dimensions of the order of ∼0.5 mm to ∼4.5 mm were used as targets behind the skull phantoms in our experiments. Minimum and maximum distortional target displacements of 2.2 mm and 25.3 mm (in 12 cm depth) were observed in sonograms when uncompensated time delays were used. By contrast, the positioning errors ranged from 0.0 to 0.9 mm when our algorithm was employed. CONCLUSION AND SIGNIFICANCE: The adaptive imaging results demonstrate strong potential of the proposed technique for diagnostic imaging of acoustically reflective head injuries directly through intact human skull.


Assuntos
Traumatismos Craniocerebrais , Ultrassom , Humanos , Crânio/diagnóstico por imagem , Ultrassonografia/métodos , Cabeça , Imagens de Fantasmas , Algoritmos
9.
PLoS Biol ; 7(9): e1000210, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19787022

RESUMO

Tree cover is a fundamental structural characteristic and driver of ecosystem processes in terrestrial ecosystems, and trees are a major global carbon (C) sink. Fire and herbivores have been hypothesized to play dominant roles in regulating trees in African savannas, but the evidence for this is conflicting. Moving up a trophic scale, the factors that regulate fire occurrence and herbivores, such as disease and predation, are poorly understood for any given ecosystem. We used a Bayesian state-space model to show that the wildebeest population eruption that followed disease (rinderpest) eradication in the Serengeti ecosystem of East Africa led to a widespread reduction in the extent of fire and an ongoing recovery of the tree population. This supports the hypothesis that disease has played a key role in the regulation of this ecosystem. We then link our state-space model with theoretical and empirical results quantifying the effects of grazing and fire on soil carbon to predict that this cascade may have led to important shifts in the size of pools of C stored in soil and biomass. Our results suggest that the dynamics of herbivores and fire are tightly coupled at landscape scales, that fire exerts clear top-down effects on tree density, and that disease outbreaks in dominant herbivores can lead to complex trophic cascades in savanna ecosystems. We propose that the long-term status of the Serengeti and other intensely grazed savannas as sources or sinks for C may be fundamentally linked to the control of disease outbreaks and poaching.


Assuntos
Doença , Ecossistema , África , Animais , Teorema de Bayes , Bases de Dados como Assunto , Incêndios , Geografia , Modelos Biológicos , Reprodutibilidade dos Testes , Vírus da Peste Bovina/fisiologia , Árvores/fisiologia
10.
Arch Dis Child Educ Pract Ed ; 97(4): 152-6, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22868579

RESUMO

Prescribing for children at the primary-secondary/tertiary care interface is more complex than that for adults. Children often need unlicensed medicines and there may be issues over who will prescribe such items. There may also be issues in obtaining unlicensed medicines (specials) from community pharmacists. This article reviews the current arrangements in England relating to prescribing for children at the interfaces of care and describes the following: prescribing responsibility, shared-care arrangements, medication continuity on admission and discharge from hospital, unlicensed medicines, continuing-care medication arrangements and highlights potential service changes to maintain access to medicines for children.


Assuntos
Prescrições de Medicamentos , Criança , Continuidade da Assistência ao Paciente , Aprovação de Drogas/legislação & jurisprudência , Humanos , Reconciliação de Medicamentos , Uso Off-Label , Equipe de Assistência ao Paciente , Serviço de Farmácia Hospitalar , Atenção Primária à Saúde , Medicina Estatal , Reino Unido
12.
Proc Natl Acad Sci U S A ; 105(52): 20770-5, 2008 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-19073931

RESUMO

Habitat destruction has driven many once-contiguous animal populations into remnant patches of varying size and isolation. The underlying framework for the conservation of fragmented populations is founded on the principles of island biogeography, wherein the probability of species occurrence in habitat patches varies as a function of patch size and isolation. Despite decades of research, the general importance of patch area and isolation as predictors of species occupancy in fragmented terrestrial systems remains unknown because of a lack of quantitative synthesis. Here, we compile occupancy data from 1,015 bird, mammal, reptile, amphibian, and invertebrate population networks on 6 continents and show that patch area and isolation are surprisingly poor predictors of occupancy for most species. We examine factors such as improper scaling and biases in species representation as explanations and find that the type of land cover separating patches most strongly affects the sensitivity of species to patch area and isolation. Our results indicate that patch area and isolation are indeed important factors affecting the occupancy of many species, but properties of the intervening matrix should not be ignored. Improving matrix quality may lead to higher conservation returns than manipulating the size and configuration of remnant patches for many of the species that persist in the aftermath of habitat destruction.


Assuntos
Ecossistema , Modelos Biológicos , Animais , Dinâmica Populacional
13.
Ultrasound Med Biol ; 47(7): 1893-1903, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33896680

RESUMO

An amplitude-dependent downshift in the fundamental wave spectrum of a propagating ultrasonic pulse caused by non-linear wave propagation is described. The effects of non-linearity and the associated downshift on spatial resolution are also studied. The amounts of downshift and spatial resolution are extracted from the numerically simulated beam profile based on the KZK equation. Results for a 25-MHz transducer reveal that non-linear effects can lead to 58% additional downshift in the centre frequency of a pulse compared with a linear case with downshift caused only by attenuation. This additional downshift causes about 50% degradation in axial resolution. However, as the beam becomes narrower from the non-linear effects, the overall effect of non-linearity still leads to improved lateral resolution (≤26%). Therefore, as non-linearity increases with wave pressure, it is concluded that the increase in source pressure improves lateral resolution and degrades axial resolution.


Assuntos
Ondas Ultrassônicas , Ultrassonografia , Fenômenos Físicos
14.
Ultrasound Med Biol ; 47(3): 809-819, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33353785

RESUMO

For tissue characterization, it is desirable to determine B/A using high-frequency transducers. Moreover, an accurate estimate of B/A at elevated frequencies (or at least the assumption of frequency independence of B/A) is required to evaluate the safety of high-frequency systems. However, common finite-amplitude approaches become increasingly inaccurate at high frequencies. In this article, a practical variation of the finite-amplitude method is proposed which combines experiments with numerical simulations of the Khokhlov-Zabolotskaya-Kuznetsov equation and can be used at elevated frequencies. The results at low frequencies show that the proposed approach is accurate with lower uncertainties compared with the finite-amplitude method because it avoids assumptions and approximations. The measured values of B/A versus frequency for water at 2.25-20 MHz show that there is no statistically significant variation in B/A values with frequency, and therefore the assumption of frequency independence of B/A is realistic.


Assuntos
Ondas Ultrassônicas , Água , Fenômenos Físicos
15.
Ecology ; 101(2): e02919, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31674003

RESUMO

The Serengeti ecosystem contains one of the most diverse bird assemblages in Africa. We present here a data set consisting of abundances of bird species in different habitats of the Serengeti ecosystem over a 87-yr time frame. This data set comprises 66,643 georeferenced occurrences for 568 species from 1929 to 2017. Most records contain feeding location, food source, distribution status, and observation locality. The records originate from three different but complementary methodologies: points, sites, and transects. The point method (bird species records 1929-2017) is based on ad hoc observations and includes rare species or those in special habitats. These points came from published records as well from the research program of A. R. E. Sinclair and colleagues. The site method (1966-2017) is based on structured observations at sites selected to represent specific habitats, and replicated within habitats and over time. At each site, birds were recorded by sight and sound over a radius of 50 m for 10 min. The transect method (1997-2011) is based on road transects covering different areas of the ecosystem. Road transects were traversed using a vehicle with observers travelling at 30 km/h. Bird species were those easily seen from a vehicle out to 50 m either side. As most transects were traversed multiple times, this method provides information on temporal change in abundance for a select set of species. No copyright restrictions apply to the use of this data set other than citing this publication.


Assuntos
Aves , Ecossistema , África , Animais , Biodiversidade
16.
Sci Data ; 7(1): 359, 2020 10 21.
Artigo em Inglês | MEDLINE | ID: mdl-33087720

RESUMO

The Serengeti ecosystem spans an extensive network of protected areas in Tanzania, eastern Africa, and a UNESCO Wold Heritage Site. It is home to some of the largest animal migrations on the planet. Here, we describe a dataset consisting of the sample counts of three age classes (infant, juvenile and adult) of 13 ungulate and one ostrich species. Sample counts were tallied visually from the ground, or, in some instances, aerial photographs, during a period extending from 1926 to 2018. Observed animals were assigned to age classes based on specific criteria for each species. For nine of the 14 species of this dataset, the number of sampling years is over 30. This resulted in a total of 533 different records of count across age classes. By computing age-class ratios, these data can be used to measure long-term recruitment success at different ages of the tallied species. In particular, the temporal extent of these data allows comparison of patterns to other long-term processes, such as the El Niño-Southern Oscillation (ENSO).


Assuntos
Envelhecimento , Artiodáctilos , Perissodáctilos , Struthioniformes , Animais , Ecossistema , Tanzânia
17.
Ultrasound Med Biol ; 45(1): 11-20, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30292462

RESUMO

Safety standards for clinical diagnostic ultrasonic devices were developed for use in relatively low-frequency systems (1-10 MHz), under the assumption that non-linear effects would be negligible. This article reviews ways in which neglecting non-linear wave propagation affects the measurements and calculations required to comply with safety standards and U.S. Food and Drug Administration guidance that recognizes these standards. An attempt is made to evaluate whether ignoring non-linear effects could result in significant error in the exposure quantities defined in these standards at either low or high frequencies, based on published literature. This article maintains that although non-linear effects have been considered in some parts of safety standards related to hydrophone requirements, the coverage is inadequate, especially for modern equipment with high working frequencies. A new approach is required to assess the magnitude of thermal heating for recently developed high-frequency systems to incorporate non-linear effects. In contrast, the current approach for evaluating the risk of cavitation can be used after appropriate modifications.


Assuntos
Segurança do Paciente , Guias de Prática Clínica como Assunto , Processamento de Sinais Assistido por Computador , Ultrassonografia/efeitos adversos , Ultrassonografia/métodos , Humanos , Estados Unidos , United States Food and Drug Administration
18.
Eur J Emerg Med ; 25(3): 216-220, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28079561

RESUMO

OBJECTIVE: Double checking medications at initial assessment within paediatric emergency departments (EDs) has the potential to delay patient flow, and doubt has been cast on the efficacy of double checking in all but high-risk medications. We aimed to benchmark current practice for the use of Patient Group Direction (PGD) medications at initial assessment in EDs within the Paediatric Emergency Research UK and Ireland (PERUKI) network, with a focus on the use of 'single-checker' PGDs. METHODS: Online survey was distributed to the research representative at each PERUKI site. The survey was open for 5 weeks (from March 2015 to April 2015) and was completed by any appropriate clinician within the site. RESULTS: The response rate was 84% (36/43 EDs). From these, 22 out of 36 (61%) EDs were using single-checker PGDs. The commonest single-checked medications in use were paracetamol and ibuprofen for pain. Among PERUKI sites, 21.9% of EDs reported drug errors related to standard (double-checked) PGDs, whereas 13.6% of those with single-checked PGDs reported drug errors (Fisher's exact test with significance level of 0.05, P=0.501). The commonest errors reported were duplicated dose, incorrect weight, incorrect volume drawn up, contraindication missed. CONCLUSION: Single-checker PGDs are currently in use in nearly two-thirds of PERUKI sites. No evidence of increased medication errors was reported with this practice; however, more detailed studies are required to support this finding and to inform best practice.


Assuntos
Serviço Hospitalar de Emergência/normas , Erros de Medicação/enfermagem , Erros de Medicação/prevenção & controle , Preparações Farmacêuticas/normas , Gestão da Segurança/métodos , Criança , Humanos , Irlanda , Avaliação em Enfermagem/estatística & dados numéricos , Guias de Prática Clínica como Assunto , Inquéritos e Questionários , Reino Unido
19.
Eur J Hosp Pharm ; 24(2): 91-95, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31156911

RESUMO

OBJECTIVES: The aim of this study was to investigate the incident reporting process (IR1s), to calculate the costs of reporting incidents in this context and to gain an indication of how economic the process was and whether it could be improved to yield better outcomes. METHODS: A retrospective analysis of a sample, 10.47% (n=150) selected from 1432 medication incident report summaries, generated at Birmingham Children's Hospital, a specialist tertiary referral paediatric centre, during 2014 and collated through the national Datix incident reporting system software was analysed and the associated staff time required to complete each step of the incident reporting process was costed. The staff costs for various grades of staff were averaged across the staff actually involved, using data calculated by the Personal Social Services Research Unit. RESULTS: The analysis showed that the incident reporting process involved 262 staff on 2942 occasions (19.16 staff episodes per incident form completed) at a cost of £337.16 per incident form completed. CONCLUSIONS: The study showed that the incident reporting system was a labour intensive process. The numbers of staff involved in the process particularly as a result of the email distribution activity did appear to have room for efficiencies. However, it proved to be relatively inexpensive from a cost perspective. With redesign, arguably the emphasis could be moved away from the recording process to learning in order to gain improved patient safety outcomes.

20.
Eur J Hosp Pharm ; 24(5): 266-271, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31156956

RESUMO

OBJECTIVE: To determine what issues are experienced during the first few weeks of therapy by patients, and their parents/carers, when a child/young person has been prescribed a new medicine. METHOD: One hundred patients aged ≤18 years of age prescribed a new medicine for ≥6 weeks were recruited from a single UK National Health Service specialist paediatric hospital outpatient pharmacy. Six weeks after the first dispensing of their new medicine the patient or their parent/carer received telephone follow-up by a researcher and verbally completed a questionnaire containing both open and closed questions. Patient or parent/carer experiences were identified and analysed using thematic analysis and descriptive statistics. RESULTS: Eighty-six participants were available for telephone follow-up. Six (7%) had not started their medicine. Paediatric patients and their parents/carers experienced a range of issues during the first few weeks after starting a new medicine. These included additional concerns/questions (24/80, 30%), administration issues (21/80, 26.3%), adverse effects (29/80, 36.3%) and obtaining repeat supplies (12/80, 15%). The Morisky Medication Adherence Scale indicated that 34/78 (43.6%) participants had a high adherence rating, 35/78 (44.9%) medium and 9/78 (11.5%) a low rating. CONCLUSIONS: Paediatric patients and their parents/carers experience a range of issues during the first few weeks after starting a new medicine. Further research is required to determine the type of interventions that may further support medicines use in this group of patients.

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