Detalhe da pesquisa
1.
How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion.
Nat Immunol
; 24(4): 637-651, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36959291
2.
Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus.
Nat Immunol
; 23(5): 731-742, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35523960
3.
A TCR mechanotransduction signaling loop induces negative selection in the thymus.
Nat Immunol
; 19(12): 1379-1390, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30420628
4.
Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus.
Nat Immunol
; 18(11): 1218-1227, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28945245
5.
Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.
Nat Immunol
; 17(12): 1415-1423, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27668801
6.
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Cell
; 154(6): 1326-41, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24034254
7.
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.
Nat Immunol
; 16(10): 1069-76, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26301566
8.
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.
Nat Immunol
; 16(5): 517-24, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25848867
9.
The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
Nat Immunol
; 15(7): 638-45, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24880459
10.
IL-7 signaling must be intermittent, not continuous, during CD8⺠T cell homeostasis to promote cell survival instead of cell death.
Nat Immunol
; 14(2): 143-51, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23242416
11.
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.
Nat Immunol
; 13(6): 569-78, 2012 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22544394
12.
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
Nat Immunol
; 11(3): 257-64, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20118929
13.
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Immunity
; 38(6): 1116-28, 2013 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746651
14.
Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155.
J Immunol
; 204(12): 3351-3359, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321756
15.
αß T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.
Immunity
; 36(1): 79-91, 2012 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209676
16.
Chromatin remodeling complex NURF regulates thymocyte maturation.
Genes Dev
; 25(3): 275-86, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21289071
17.
Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
Immunity
; 31(3): 480-90, 2009 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19747858
18.
Coreceptor gene imprinting governs thymocyte lineage fate.
EMBO J
; 31(2): 366-77, 2012 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22036949
19.
Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function.
J Immunol
; 192(6): 2892-903, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24523508
20.
MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.
Trends Immunol
; 33(9): 437-41, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22771139