Detalhe da pesquisa
1.
DNA-based fluorescent probes of NOS2 activity in live brains.
Proc Natl Acad Sci U S A
; 117(26): 14694-14702, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32554491
2.
Negative evidence for a role of APH1B T27I variant in Alzheimer's disease.
Hum Mol Genet
; 29(6): 955-966, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31995180
3.
Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
J Neurosci
; 39(34): 6766-6780, 2019 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31217332
4.
Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.
J Biol Chem
; 291(13): 6748-53, 2016 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26887941
5.
Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.
J Biol Chem
; 290(30): 18609-20, 2015 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085104
6.
Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.
Proc Natl Acad Sci U S A
; 110(22): 9148-53, 2013 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23674689
7.
Differential release of ß-amyloid from dendrite- versus axon-targeted APP.
J Neurosci
; 34(37): 12313-27, 2014 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25209273
8.
Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons.
J Neurosci
; 34(10): 3668-73, 2014 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24599465
9.
A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.
J Biol Chem
; 289(50): 34851-61, 2014 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25352592
10.
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.
Proc Natl Acad Sci U S A
; 109(22): 8534-9, 2012 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22586122
11.
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species.
Biochemistry
; 53(4): 702-13, 2014 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24401146
12.
Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function.
Sci Rep
; 14(1): 1827, 2024 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38246956
13.
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Mol Neurodegener
; 19(1): 18, 2024 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38365827
14.
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
J Neurosci
; 32(25): 8633-48, 2012 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22723704
15.
Activation and intrinsic gamma-secretase activity of presenilin 1.
Proc Natl Acad Sci U S A
; 107(50): 21435-40, 2010 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21115843
16.
The gut microbiome in Alzheimer's disease: what we know and what remains to be explored.
Mol Neurodegener
; 18(1): 9, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36721148
17.
Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome.
Mol Neurodegener
; 18(1): 95, 2023 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38104136
18.
The gut microbiome regulates astrocyte reaction to Aß amyloidosis through microglial dependent and independent mechanisms.
Mol Neurodegener
; 18(1): 45, 2023 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37415149
19.
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.
Science
; 379(6628): eadd1236, 2023 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36634180
20.
BMS-708,163 targets presenilin and lacks notch-sparing activity.
Biochemistry
; 51(37): 7209-11, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22931393