Postoperative calculation of acetabular cup position using 2-D-3-D registration.

A method to accurately measure the position and orientation of an acetabular cup implant from postoperative X-rays has been designed and validated. The method uses 2-D-3-D registration to align both the prosthesis and the preoperative computed tomography (CT) volume to the X-ray image. This allows the position of the implant to be calculated with respect to a CT-based surgical plan. Experiments have been carried out using ten sets of patient data. A conventional plain-film measurement technique was also investigated. A gold standard implant position and orientation was calculated using postoperative CT. Results show our method to be significantly more accurate than the plain-film method for calculating cup anteversion. Cup orientation and position could be measured to within a mean absolute error of 1.4 mm or degrees.

Self-calibrating 3D-ultrasound-based bone registration for minimally invasive orthopedic surgery.

Intraoperative freehand three-dimensional (3-D) ultrasound (3D-US) has been proposed as a noninvasive method for registering bones to a preoperative computed tomography image or computer-generated bone model during computer-aided orthopedic surgery (CAOS). In this technique, an US probe is tracked by a 3-D position sensor and acts as a percutaneous device for localizing the bone surface. However, variations in the acoustic properties of soft tissue, such as the average speed of sound, can introduce significant errors in the bone depth estimated from US images, which limits registration accuracy. We describe a new self-calibrating approach to US-based bone registration that addresses this problem, and demonstrate its application within a standard registration scheme. Using realistic US image data acquired from 6 femurs and 3 pelves of intact human cadavers, and accurate Gold Standard registration transformations calculated using bone-implanted fiducial markers, we show that self-calibrating registration is significantly more accurate than a standard method, yielding an average root mean squared target registration error of 1.6 mm. We conclude that self-calibrating registration results in significant improvements in registration accuracy for CAOS applications over conventional approaches where calibration parameters of the 3D-US system remain fixed to values determined using a preoperative phantom-based calibration.

Instantiation and registration of statistical shape models of the femur and pelvis using 3D ultrasound imaging.

Statistical shape modelling potentially provides a powerful tool for generating patient-specific, 3D representations of bony anatomy for computer-aided orthopaedic surgery (CAOS) without the need for a preoperative CT scan. Furthermore, freehand 3D ultrasound (US) provides a non-invasive method for digitising bone surfaces in the operating theatre that enables a much greater region to be sampled compared with conventional direct-contact (i.e., pointer-based) digitisation techniques. In this paper, we describe how these approaches can be combined to simultaneously generate and register a patient-specific model of the femur and pelvis to the patient during surgery. In our implementation, a statistical deformation model (SDM) was constructed for the femur and pelvis by performing a principal component analysis on the B-spline control points that parameterise the freeform deformations required to non-rigidly register a training set of CT scans to a carefully segmented template CT scan. The segmented template bone surface, represented by a triangulated surface mesh, is instantiated and registered to a cloud of US-derived surface points using an iterative scheme in which the weights corresponding to the first five principal modes of variation of the SDM are optimised in addition to the rigid-body parameters. The accuracy of the method was evaluated using clinically realistic data obtained on three intact human cadavers (three whole pelves and six femurs). For each bone, a high-resolution CT scan and rigid-body registration transformation, calculated using bone-implanted fiducial markers, served as the gold standard bone geometry and registration transformation, respectively. After aligning the final instantiated model and CT-derived surfaces using the iterative closest point (ICP) algorithm, the average root-mean-square distance between the surfaces was 3.5mm over the whole bone and 3.7mm in the region of surgical interest. The corresponding distances after aligning the surfaces using the marker-based registration transformation were 4.6 and 4.5mm, respectively. We conclude that despite limitations on the regions of bone accessible using US imaging, this technique has potential as a cost-effective and non-invasive method to enable surgical navigation during CAOS procedures, without the additional radiation dose associated with performing a preoperative CT scan or intraoperative fluoroscopic imaging. However, further development is required to investigate errors using error measures relevant to specific surgical procedures.

Self-calibrating ultrasound-to-CT bone registration.

We describe a new self-calibrating approach to rigid registration of 3D ultrasound images in which in vivo data acquired for registration are used to simultaneously perform a patient-specific update of the calibration parameters of the 3D ultrasound system. Using a self-calibrating implementation of a point-based registration algorithm, and points obtained from ultrasound images of the femurs and pelves of human cadavers, we show that the accuracy of registration to a CT scan is significantly improved compared with a standard algorithm. This new approach provides an effective means of compensating for errors introduced by the propagation of ultrasound through soft tissue, which currently limit the accuracy of conventional methods where the calibration parameters are fixed to values determined preoperatively using a phantom.

Cadaver validation of intensity-based ultrasound to CT registration.

A method is presented for the registration of tracked B-mode ultrasound images to a CT volume of a femur or pelvis. This registration can allow tracked surgical instruments to be aligned with the CT image or an associated preoperative plan. Our method requires no manual segmentation of either the ultrasound images or the CT volume. The CT and US images are processed to produce images where the image intensity represents the probability of the presence of a bone edge. These images are then registered together using normalised cross-correlation as a similarity measure. The parameter which represents the speed of sound through tissue has also been included in the registration optimisation process. Experiments have been carried out on six cadaveric femurs and three cadaveric pelves. Registration results were compared with a "gold standard" registration acquired using bone implanted fiducial markers. Results show the registration method to be accurate, on average, to 1.7 mm root-mean-square target registration error.