Detalhe da pesquisa
1.
Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics.
Nucleic Acids Res
; 50(11): 6020-6037, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35687098
2.
Genome-wide association study of abnormal elevation of ALT in patients exposed to atabecestat.
BMC Genomics
; 24(1): 513, 2023 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37658353
3.
AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules.
Chem Res Toxicol
; 36(7): 1129-1139, 2023 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37294641
4.
Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat.
Allergy
; 76(6): 1825-1835, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33150583
5.
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Toxicol Appl Pharmacol
; 403: 115163, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32730777
6.
Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes.
Drug Metab Dispos
; 47(5): 453-464, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30787101
7.
High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.
Arch Toxicol
; 93(10): 2895-2911, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31552476
8.
Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30181376
9.
MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study.
Drug Metab Dispos
; 46(5): 697-703, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29523599
10.
In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.
Br J Clin Pharmacol
; 83(5): 1082-1096, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27862160
11.
In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs.
Pharm Res
; 34(4): 750-764, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28097507
12.
In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity.
Drug Metab Dispos
; 44(10): 1682-91, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27504016
13.
Stable isotope-labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults.
Br J Clin Pharmacol
; 81(2): 235-45, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26382728
14.
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.
Arch Toxicol
; 90(12): 2979-3003, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27659300
15.
A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4.
Biopharm Drug Dispos
; 37(1): 15-27, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26356245
16.
In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System.
Int J Mol Sci
; 17(4): 584, 2016 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27092500
17.
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.
Pharm Res
; 32(1): 260-74, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25048637
18.
Therapeutic siRNA Loaded to RISC as Single and Double Strands Requires an Appropriate Quantitative Assay for RISC PK Assessment.
Nucleic Acid Ther
; 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38638105
19.
Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel bioavailability in rats.
Int J Pharm
; 654: 123965, 2024 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38442796
20.
Pharmacokinetic interaction between telaprevir and methadone.
Antimicrob Agents Chemother
; 57(5): 2304-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23478952