1.
Adv Exp Med Biol
; 507: 303-7, 2002.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12664601
RESUMO
A series of prostaglandins selective for the human FP receptor have been synthesized and evaluated as potential therapeutics for the treatment of osteoporosis. The compounds proved to be potent (nanomolar binding affinity) and selective (> 100x) ligands for the human FP receptor in vitro, and increased bone volume in the ovariectomized rat in vivo.