RESUMO
An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentration is presented. The predictions are compared with four other available estimating methods, bases on values in 110 subjects with renal impairment of widely differing degrees. In patients with stable and with unstable renal function the corelaion between measured and predicted CrCl was better with the new equation. In patients with rapid changing renal function the new equation resulted in accurate predictions CrCl within a few hours after the change, as opposed to several with the other methods. The elimination rate constant of the aminoglycoside antibiotic amikacin correlated more precisely with CrCl values estimated from the new equation that with those measured doing 24 hr or with the other prediction methods.
Assuntos
Composição Corporal , Creatinina/metabolismo , Injúria Renal Aguda/metabolismo , Adolescente , Adulto , Idoso , Amicacina/administração & dosagem , Amicacina/metabolismo , Amicacina/urina , Creatinina/sangue , Creatinina/urina , Feminino , Humanos , Injeções Intravenosas , Rim/fisiologia , Rim/fisiopatologia , Masculino , Taxa de Depuração Metabólica/efeitos dos fármacos , Pessoa de Meia-Idade , Probabilidade , Análise de Regressão , Dobras CutâneasAssuntos
Antibacterianos/uso terapêutico , Cefotetan/uso terapêutico , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Procedimentos Cirúrgicos Eletivos/efeitos adversos , Infecção da Ferida Cirúrgica/prevenção & controle , Antibioticoprofilaxia , Ensaios Clínicos Controlados como Assunto , Procedimentos Cirúrgicos do Sistema Digestório/classificação , Humanos , Complicações Pós-Operatórias/prevenção & controle , Infecções Urinárias/prevenção & controleRESUMO
The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied. In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.