Detalhe da pesquisa
1.
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
J Clin Invest
; 95(2): 555-63, 1995 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-7860738
2.
Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells.
Cancer Res
; 45(10): 4900-3, 1985 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-3928143
3.
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.
Cancer Res
; 47(8): 2203-6, 1987 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-3829006
4.
Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes.
Cancer Res
; 55(14): 3036-42, 1995 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-7606724
5.
Kinetics and metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine, in humans.
Cancer Res
; 43(2): 930-3, 1983 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-6216947
6.
Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation.
Cancer Res
; 45(1): 116-21, 1985 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-3965128
7.
Evidence from rat hepatocytes of an unrecognized pathway of 5-fluorouracil metabolism with the formation of a glucuronide derivative.
Cancer Res
; 45(6): 2450-5, 1985 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-3986786
8.
Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. AIDS Clinical Trial Group No. 215 Team.
J Clin Oncol
; 16(4): 1444-9, 1998 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-9552050
9.
Cellular nucleoside pharmacokinetics and pharmacology: a potentially important determinant of antiretroviral efficacy.
AIDS
; 12 Suppl 3: S1-8, 1998.
Artigo
em Inglês
| MEDLINE | ID: mdl-15168717
10.
HIV protease inhibitors: pharmacologic and metabolic distinctions.
AIDS
; 13 Suppl 1: S29-40, 1999 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-10546783
11.
Plasma population pharmacokinetics and penetration into cerebrospinal fluid of indinavir in combination with zidovudine and lamivudine in HIV-1-infected patients.
AIDS
; 14(18): 2869-76, 2000 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11153668
12.
Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir.
AIDS
; 14(9): 1187-94, 2000 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-10894283
13.
Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: results of Adult AIDS Clinical Trials Group protocol 370.
AIDS
; 14(11): 1553-61, 2000 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-10983642
14.
Lamivudine in combination with zidovudine, stavudine, or didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group Protocol 306 Investigators.
AIDS
; 13(6): 685-94, 1999 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-10397563
15.
Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases.
Clin Infect Dis
; 33(11): 1914-21, 2001 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11692304
16.
Reduction of 3'-azido-3'-deoxythymidine to 3'-amino-3'-deoxythymidine in human liver microsomes and its relationship to cytochrome P450.
Clin Pharmacol Ther
; 54(2): 168-76, 1993 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-8354026
17.
Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine.
Clin Pharmacol Ther
; 51(6): 668-76, 1992 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-1611806
18.
Pharmacological considerations in antiretroviral therapy.
Antivir Ther
; 3 Suppl 4: 9-12, 1998.
Artigo
em Inglês
| MEDLINE | ID: mdl-10723503
19.
Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil.
J Med Chem
; 37(16): 2583-8, 1994 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-8057301
20.
Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.
J Med Chem
; 39(26): 5202-7, 1996 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-8978848