Detalhe da pesquisa
1.
Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions.
Neurobiol Dis
; 191: 106411, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38228253
2.
Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study.
Eur J Neurosci
; 59(7): 1585-1603, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38356120
3.
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.
J Neuroinflammation
; 21(1): 108, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38664840
4.
AAV9-Mediated Intra-Striatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice.
J Pharmacol Exp Ther
; 2024 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38866563
5.
Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age.
Neurobiol Dis
; 181: 106111, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001610
6.
Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS.
J Neurosci
; 41(9): 2039-2052, 2021 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33472823
7.
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity.
Neurobiol Dis
; 171: 105804, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35764290
8.
Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.
Mov Disord
; 37(8): 1739-1748, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35524682
9.
BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease.
Neuromodulation
; 25(6): 846-853, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34288271
10.
Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
J Neurosci
; 40(18): 3675-3691, 2020 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32238479
11.
The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats.
Neurobiol Dis
; 148: 105175, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33188920
12.
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Neurobiol Dis
; 141: 104947, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32422283
13.
Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway.
Mol Cell Proteomics
; 17(9): 1778-1787, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29915149
14.
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.
Neurobiol Dis
; 130: 104525, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31276792
15.
BDNF provides many routes toward STN DBS-mediated disease modification.
Mov Disord
; 34(1): 22-34, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30440081
16.
Cell therapy for Parkinson's disease: Why it doesn't work every time.
Mov Disord
; 34(8): 1120-1127, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31234239
17.
Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia.
Mov Disord
; 34(5): 697-707, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31002755
18.
Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.
J Neurosci
; 37(28): 6786-6796, 2017 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28607168
19.
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
J Neuroinflammation
; 15(1): 129, 2018 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29716614
20.
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
J Neuroinflammation
; 15(1): 169, 2018 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29843738