Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Revista
País de afiliação
Intervalo de ano de publicação
1.
Nature ; 539(7630): 530-535, 2016 11 24.
Artigo em Inglês | MEDLINE | ID: mdl-27749817

RESUMO

Various rod-shaped bacteria mysteriously glide on surfaces in the absence of appendages such as flagella or pili. In the deltaproteobacterium Myxococcus xanthus, a putative gliding motility machinery (the Agl-Glt complex) localizes to so-called focal adhesion sites (FASs) that form stationary contact points with the underlying surface. Here we show that the Agl-Glt machinery contains an inner-membrane motor complex that moves intracellularly along a right-handed helical path; when the machinery becomes stationary at FASs, the motor complex powers a left-handed rotation of the cell around its long axis. At FASs, force transmission requires cyclic interactions between the molecular motor and the adhesion proteins of the outer membrane via a periplasmic interaction platform, which presumably involves contractile activity of motor components and possible interactions with peptidoglycan. Our results provide a molecular model of bacterial gliding motility.


Assuntos
Aderência Bacteriana/fisiologia , Proteínas de Bactérias/metabolismo , Adesões Focais/metabolismo , Myxococcus xanthus/fisiologia , Proteínas da Membrana Bacteriana Externa/metabolismo , Movimento Celular , Proteínas Motores Moleculares/metabolismo , Myxococcus xanthus/citologia , Periplasma/metabolismo , Rotação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA