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Clin Immunol ; 217: 108482, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32470543

RESUMO

Chronic hepatitis C virus (HCV) infection induces liver damage and the HCV/Human Immunodeficiency Virus (HIV)-coinfection may further contribute to its progression. The HLA-G molecule inhibits innate and adaptive immunity and may be deleterious for chronically virus-infected cells. Thus we studied 204 HCV-mono-infected patients, 142 HCV/HIV-coinfected patients, 104 HIV-mono-infected patients and 163 healthy subjects. HLA-G liver expression was similarly induced in HCV and HCV/HIV specimens, increasing with advanced fibrosis and necroinflammatory activity, and with increased levels of liver function-related enzymes. Plasma soluble HLA-G (sHLA-G) levels were higher in HCV/HIV patients compared to HCV, HIV and to healthy individuals. sHLA-G continued to be higher in coinfected patients even after stratification of samples according to degree of liver fibrosis and necroinflammatory activity when compared to mono-infected patients. Some HLA-G gene haplotypes differentiated patient groups and presented few associations with liver and plasma HLA-G expression. HLA-G thus may help to distinguish patient groups.


Assuntos
Infecções por HIV/imunologia , Antígenos HLA-G/genética , Antígenos HLA-G/metabolismo , Hepatite C Crônica/imunologia , Fígado/metabolismo , Adulto , Coinfecção , Feminino , Regulação da Expressão Gênica/genética , Regulação da Expressão Gênica/imunologia , HIV-1/imunologia , Haplótipos/genética , Hepacivirus/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético/genética , Estudos Retrospectivos
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