Resistance Exercise Order Does Not Affect the Magnitude and Duration of Postexercise Blood Pressure in Older Women.

Tomeleri, CM, Nunes, JP, Souza, MF, Gerage, AM, Marcori, A, Iarosz, KC, Cardoso-Júnior, CG, and Cyrino, ES. Resistance exercise order does not affect the magnitude and duration of postexercise blood pressure in older women. J Strength Cond Res 34(4): 1062-1070, 2020-The aim of this study was to compare the effects of 2 resistance exercise order on postexercise blood pressure (BP) in trained nonhypertensive older women. Sixteen women (68.3 ± 3.3 years, 63.5 ± 11.6 kg, 157.5 ± 5.1 cm) performed 2 sessions with 8 exercises (3 sets of 8-12 repetitions) in distinct orders (from multi- to single-joint exercises [MS] or from single- to multijoint exercises [SM]) and a control session (CS), without exercise. Blood pressure and heart rate (HR) were obtained pre- and postsessions (60 minutes). Postexercise hypotension was observed for systolic BP (SBP) and mean BP in both the MS session (SBP: -6.9 mm Hg, mean BP: -3.3 mm Hg, p ≤ 0.05) and SM session (SBP: -4.6 mm Hg; mean BP: -1.1 mm Hg). Postexercise HR was higher than presession values until 30 minutes of recovery in both training sessions. Furthermore, SBP and mean BP, and HR were lower than the values obtained in the CS (30-60 minutes and 0 minutes, respectively; p ≤ 0.05). There were no differences between the SM and MS sessions in any variable or at any moment. In conclusion, resistance exercise order does not interfere in the magnitude and duration of postexercise hypotension in trained nonhypertensive older women.

Influence of Resistance Training Exercise Order on Muscle Strength, Hypertrophy, and Anabolic Hormones in Older Women: A Randomized Controlled Trial.

Tomeleri, CM, Ribeiro, AS, Nunes, JP, Schoenfeld, BJ, Souza, MF, Schiavoni, D, Junior, PS, Cavaglieri, CR, Cunha, PM, Venturini, D, Barbosa, DS, and Cyrino, ES. Influence of resistance training exercise order on muscle strength, hypertrophy, and anabolic hormones in older women: a randomized controlled trial. J Strength Cond Res 34(11): 3103-3109, 2020-The purpose of this study was to analyze the effects of resistance training (RT) exercise order on muscle strength, hypertrophy, and anabolic hormones in older women. Forty-four older women were randomly assigned to 1 of 3 groups: a nonexercise control group (CON, n = 15) and two RT groups that performed a 12-week RT program in a multijoint to single-joint order (MJ-SJ, n = 14), or in a single-joint to multijoint order (SJ-MJ, n = 15). The RT protocol (3×/week) encompassed 8 exercises, with 3 sets of 10-15 repetitions performed per exercise. One repetition maximum tests were used to evaluate muscle strength; dual-energy X-ray absorptiometry was used to estimate lean soft tissue. Both training groups showed significant and similar increases in muscle strength (MJ-SJ = 16.4%; SJ-MJ = 12.7%) and mass (MJ-SJ = 7.5%; SJ-MJ = 6.1%), whereas there were no significant changes in testosterone and insulin-like growth factor 1. The results suggest that both approaches are similarly effective in eliciting morphofunctional improvements in older women.

The effects of resistance training volume on osteosarcopenic obesity in older women.

The aim of this study was to analyze the effects of resistance training (RT) performed with 1 or 3 sets per exercise on osteosarcopenic obesity (OSO) syndrome parameters in older women. Sixty-two older women (68.0 ± 4.3 years, 26.8 ± 4.4 kg/m2) participated in a 12-week RT program. Participants were randomly assigned into one of the three groups: two training groups that performed either 1 set (G1S, n = 21) or 3 sets (G3S, n = 20) 3 times weekly, or a control group (CG, n = 21). Body composition was assessed by dual X-ray absorptiometry, strength was evaluated by 1 repetition maximum testing. The G3S presented significantly higher strength changes than G1S. The changes for percentage of body fat were higher for G3S compared to G1S. There was no difference in skeletal muscle mass between G3S and G1S, however both training groups displayed greater increases in this outcome compared to CG. There was no effect for bone mineral density. The overall analysis indicated higher (P < 0.05) positive changes for G3S than G1S (composed Z-score: G3S = 0.62 ± 0.40; G1S = 0.11 ± 0.48). The results suggest that a 12-week RT period is effective to improve the risk factors of OSO, and that 3 sets induce higher improvements than a single set.

Chronic Blood Pressure Reductions and Increments in Plasma Nitric Oxide Bioavailability.

This study analyzed the effects of 12 weeks of resistance training (RT) on resting blood pressure (BP) and plasma levels of nitric oxide metabolites (NOx) in pre- and hypertensive older women, and evaluated the relationship between these 2 parameters. Thirty-five older women (68.2±5.7 years, 70.0±14.4 kg, 157.1±6.4 cm, 28.3±5.0 kg.m-2) were randomly allocated into a training group (TG; n=17), which performed a 12-week RT program, and a control group (CG; n=18), which did not perform any physical exercise. Anthropometry, one repetition maximum (1RM), body composition analysis by dual energy X-ray absorptiometry, blood samples, and resting BP were measured. There was a significant interaction for all variables analyzed, in which reductions of systolic BP (-8.5%), diastolic BP (-8.4%), and mean arterial pressure (-8.5%), and increases of NOx (+35.2%) were observed only for the TG. Moreover, a negative and significant correlation was observed (P<0.05; r=-0.63) between NOx and systolic BP in the TG. Results suggest that a 12-week RT program is sufficient to induce reductions in BP in pre- and hypertensive older women and that the decrease in systolic BP is associated with an increase in plasma NOx concentration.

Correlates of sports practice, occupational and leisure-time physical activity in Brazilian adolescents.

OBJECTIVES: To analyze the relationship between different physical activity (PA) domains and sociodemographic, psychological, behavioral and biological factors in Brazilian adolescents. METHODS: 1,220 adolescents (55.1% female) aged between 10 and 16 years-old participated in this study. The Baecke questionnaire was used to evaluate different PA domains, namely occupational, sports and leisure-time. Socioeconomic status, number of siblings, friendships satisfaction, mother's and father's PA level and previous experience with sports were self-reported. Cardiorespiratory fitness, waist circumference, and somatic maturity were estimated by objective indicators. Linear regression was used for the main statistical analysis. RESULTS: The variables consistently related to all of the PA domains were gender (boys more active), friendship satisfaction (positive with sports and leisure-time PA and negative with occupational PA) and cardiorespiratory fitness (positive). There were also domain-specific relationships for occupational (number of siblings [ß = 0.02] and father's PA [ß = 0.13]), sport practice (previous experience with sports [ß = 0.33], waist circumference [ß = 0.01] and somatic maturity [ß = -0.12]) and leisure-time PA (chronological age [ß = -0.15], mother's PA [ß = 0.47] and previous experience with sports [ß = 0.17]). CONCLUSIONS: The different domains of PA are related to specific variables in adolescence. This information may be helpful in formulating strategies for physical activity promotion, particularly in adolescents from low-to-middle income countries.

Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10.

Current therapies against malignant melanoma generally fail to increase survival in most patients, and immunotherapy is a promising approach as it could reduce the dosage of toxic therapeutic drugs. In the present study, we show that an immunotherapeutic approach based on the use of the Toll-like receptor (TLR)-5 ligand flagellin (Salmonella Typhimurium FliCi) combined with the major histocompatibility complex class II-restricted P10 peptide, derived from the Paracoccidioides brasiliensis gp43 major surface protein, reduced the number of lung metastasis in a murine melanoma model. Compounds were administered intranasally into C57Bl/6 mice intravenously challenged with syngeneic B16F10-Nex2 melanoma cells, aiming at the local (pulmonary) immune response modulation. Along with a marked reduction in the number of lung nodules, a significant increase in survival was observed. The immunization regimen induced both local and systemic proinflammatory responses. Lung macrophages were polarized towards a M1 phenotype, lymph node cells, and splenocytes secreted higher interleukin-12p40 and interferon (IFN)-γ levels when re-stimulated with tumor antigens. The protective effect of the FliCi+P10 formulation required TLR-5, myeloid differentiation primary response gene 88 and IFN-γ expression, but caspase-1 knockout mice were only partially protected, suggesting that intracellular flagellin receptors are not involved with the anti-tumor effect. The immune therapy resulted in the activation of tumor-specific CD4(+) T lymphocytes, which conferred protection to metastatic melanoma growth after adoptive transfer. Taken together, our results report a new immunotherapeutic approach based on TLR-5 activation and IFN-γ production capable to control the metastatic growth of B16F10-Nex2 melanoma, being a promising alternative to be associated with chemotherapeutic drugs for an effective anti-tumor responses.

Effect of different warm-up procedures on the performance of resistance training exercises.

Warm-up has been shown to mediate numerous acute physiological alterations that have been purported to confer beneficial effects on performance. This study investigated the acute effects of different warm-up procedures on resistance training performance. Employing a randomized, counterbalanced crossover design, 15 men performed 3 exercises (4 sets of bench press, squat, and arm curl at 80% of 1RM) to failure in 4 conditions (control, specific, aerobic, and combined). Outcome measures included the sum of repetitions and a fatigue index measuring the decline between sets. There was no significant difference for the sum of repetitions or for fatigue index among conditions for the 3 exercises. Performance in the resistance training exercises was not influenced by warm-up.

Phase Angle Is Moderately Associated With Muscle Quality and Functional Capacity, Independent of Age and Body Composition in Older Women.

BACKGROUND AND PURPOSE: There is a growing body of evidence indicating that phase angle (PhA) can be used as an indicator of nutritional status, disease prognosis, and mortality risk; however, it is still unknown whether PhA can be used as an explanator of functional capacity and muscle quality in older women. The main purpose of this cross-sectional study was to explore whether PhA is associated with muscle quality and functional capacity in older women, regardless of total and regional body composition. METHODS: A total of 125 older women-66.7 (4.7) years; 65.6 (10.9) kg body mass; 156.1 (5.2) cm height; 26.9 (4.0) kg/m body mass index-participated in this study. Anthropometric, PhA, body composition (whole-body dual-energy x-ray absorptiometry) and muscle quality (defined as total muscular strength per kilogram of appendicular lean soft tissue) were measured. The functional capacity was assessed by 4 tests: 10-m walk test, rising from sitting position, rising from ventral decubitus position, and rising from a chair and walking around the house. The summing z-scores for the 4 tests was used as a continuous functional capacity score. Linear regression analysis was conducted to test whether PhA is related to the dependent variables (muscle quality and functional capacity), after adjusting for potential covariates. RESULTS: The PhA presented a small-to-moderate relationship with muscle quality (r = 0.27; P < .01) and functional capacity (r = 0.31; P < .01), respectively. These relationships remained significant after adjustment for age, lower limb lean soft tissue, and total fat mass for muscle quality (ß= 0.55; P < .01) and functional capacity (ß= 1.38; P < .01). CONCLUSION: Our findings suggest that healthy elderly women with higher values of PhA have a better muscle quality and functionality, regardless of age and body composition.

Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial.

BACKGROUND: This study analyzed the effects of a 12-week resistance training (RT) program without dietary interventions on metabolic syndrome (MetS) components and inflammatory biomarkers in older women. METHODS: Fifty-three older women (mean [±SD] age 70.4 ± 5.7 years; mean body mass index 26.7 ± 4.0 kg/m2 ) were randomly assigned to a training group (TG; n = 26) that performed 12 weeks of an RT program or a control group (CG; n = 27) that did not perform any type of physical exercise over the same period. Body composition (dual energy X-ray absorptiometry), muscular strength (one-repetition maximum tests), blood pressure (BP), and blood sample measurements were performed before and after intervention. RESULTS: After the 12-week period, there were significantly reductions (P < 0.05) in glucose levels (-20.4% vs -0.3%), waist circumference (-1.5% vs +2.0%), and systolic BP (-6.2% vs +0.9%), and complete normalization of MetS prevalence (18% at baseline vs. 0% after 12-weeks RT) in the TG. Moreover, C-reactive protein and tumor necrosis factor-α concentrations decreased in the TG (-28.6% and -21.6%, respectively), but increased in the CG (+34.5% and +13.3%, respectively). In addition there were positive improvements in the MetS Z-score in the TG but not CG (-21.6% vs +13.3%, respectively). CONCLUSION: The results suggest that a 12-week RT program seems to effectively reduce MetS components and inflammatory biomarkers in older women, regardless of dietary intervention. The RT-induced adaptations in body composition and inflammatory biomarkers appear to be related to healthy adaptations in risk factors for MetS.

The improvement in walking speed induced by resistance training is associated with increased muscular strength but not skeletal muscle mass in older women.

OBJECTIVE: The purpose of the present study was to analyze whether improvements in fast walking speed induced by resistance training (RT) are associated with changes in body composition, muscle quality, and muscular strength in older women. METHODS: Twenty-three healthy older women (69.6 ± 6.4 years, 64.95 ± 12.9 kg, 1.55 ± 0.07 m, 27.06 ± 4.6 kg/m²) performed a RT program for 8 weeks consisting of 8 exercises for the whole body, 3 sets of 10-15 repetitions maximum, 3 times a week. Anthropometric, body composition (fat-free mass [FFM], skeletal muscle mass [SMM], legs lean soft tissue [LLST], fat mass), knee extension muscular strength (KE1RM), muscle quality index (MQI [KE1RM/LLST]), and 10-meter walking test (10-MWT) were performed before and after the intervention. RESULTS: Significant (P < .05) changes were observed from pre- to post-training for FFM (+1.6%), MQI (+7.2%), SMM (+2.4%), LLST (+1.8%), KE1RM (+8.6%), fat mass (-1.4%), and time to perform 10-MWT (-3.7%). The percentage change in 10-MWT was significantly associated with percentage change in MQI (r = -0.46, P = .04) and KE1RM (r = -0.45, P = .04), however not associated percentage of changes in SMM (r = 0.01, P = .97), LLST (r = -0.22, P = .33), and body fat (r = 0.10, P = .66). CONCLUSION: We conclude that the improvement in the 10-MWT after an 8-week RT program is associated with increases in lower limb muscular strength and muscle quality, but not with muscle mass or body fat changes in older women.

Resistance training prescription with different load-management methods improves phase angle in older women.

The purpose of the present study was to investigate the effect of two different resistance training (RT) prescription methods on phase angle (PA) in older women. Seventy-six older women (68.5 ± 5.7 years) were randomly assigned to one of three groups: two training groups that performed an eight-week RT programme either in a constant load (CT, n = 25) or an ascending pyramidal load (PR, n = 26) routine three times per week, or a control group (CG, n = 25) that performed no exercise. The CT programme consisted of three sets of 8-12 repetition maximum (RM) with a constant load for the three sets, whereas the PR training consisted of three sets of 12/10/8 RM with incremental loads for each set. PA was assessed by whole-body spectral bioelectrical impedance. After the RT period, both CT and PR achieved higher (P < .05) values of PA (CT = 5.76 ± 0.59°, PR = 5.63 ± 0.61°, CG = 5.48 ± 0.46°) compared to the CG; however, there was no difference (P > .05) between trained groups. The results suggest that eight weeks of RT based on a PR and CT load routines promote an improvement in PA, and both prescription methods performed similarly.

Traditional and pyramidal resistance training systems improve muscle quality and metabolic biomarkers in older women: A randomized crossover study.

The purpose of this study was to compare the effect of RT performed in a pyramid (PR) and traditional (TD) straight set training system on muscle quality and metabolic biomarkers in older women. Twenty-five physically independent older women (67.6±5.1years, 65.9±11.1kg, 154.7±5.8cm) performed a RT program in TD and PR training systems in a balanced crossover design. Measurements of muscle quality, serum levels of C-reactive protein (CRP), glucose (GLU), total cholesterol, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and triglycerides (TG) were obtained at different moments. The TD program consisted of 3 sets of 8-12 repetitions maximum (RM) with a constant weight for the 3 sets, whereas the PR training consisted of 3 sets of 12/10/8 RM with incremental weight for each set. The training was performed in 2 phases of 8weeks each, with a 12-week washout period between phases. Significant (P<0.05) improvements were observed in both groups for muscle quality (TD=+8.6% vs. PR=+6.8%), GLU (TD=-4.5% vs. PR=-1.9%), TG (TD=-18.0% vs. PR=-11.7%), HDL-C (TD=+10.6 vs. PR=+7.8%), LDL-C (TD=-23.3% vs. PR=-21.0%), and CRP (TD=-19.4% vs. PR=-14.3%) with no differences between training systems. These results suggest that RT improves muscle quality and metabolic biomarkers of older women independently of the training system.

Resistance training improves inflammatory level, lipid and glycemic profiles in obese older women: A randomized controlled trial.

The main purpose of the present study was to investigate the effect of resistance training on inflammatory levels, lipid and glycemic profile in obese older women. Thirty-eight obese older women (68.2±4.2years, and 41.0±6.2% of body fat) were randomly assigned to one of two groups: A training group (TG, n=19) that performed 8weeks of RT; or a control group (CG, n=19) that did not perform any type of exercise. The RT program consisted of 8 whole-body exercises for 3 sets of 10-15 repetition maximum (RM) carried out 3 times a week. Anthropometric, body composition (DXA), muscular strength (1RM), and blood sample measurements were performed pre- and post-training. After the intervention period, the TG demonstrated significantly (P<0.05) lower values than CG for interleukin-6 (TG=3.3±1.2pg/mL vs. CG=3.8±1.4pg/mL), tumor necrosis factor alpha (TG=3.1±1.5pg/mL vs. CG=3.5±1.8pg/mL), C-reactive protein (TG=1.8±1.4mg/L vs. CG=3.2±1.8mg/L), low-density lipoprotein (TG=85.1±11.0mg/dL vs. CG=148.7±0.1mg/dL), glucose (TG=90.8±11.1mg/dL vs. CG=97.9±6.9mg/dL), trunk fat (TG=12.7±3.5kg vs. CG=14.1±4.3kg), and total body fat (TG=37.5±5.7% vs. CG=43.1±5.6%). Furthermore, TG presented significantly (P<0.05) higher values for high-density lipoprotein (TG=58.3±15.4mg/dL vs. CG=55.2±11.8mg/dL). These results suggest that 8weeks of RT promote improvements on inflammatory levels, and the lipid and glycemic profile in obese older women. These findings further support the important role of RT in healthy aging.

Correlates of Blood Pressure According to Early, On Time, and Late Maturation in Adolescents.

The aim of this study was to estimate the prevalence and correlates of blood pressure (BP) according to somatic maturation in Southern Brazilian adolescents. A total of 1321 adolescents participated in the study (732 girls), aged between 10 and 16 years, enrolled in public schools. The assessment of BP was performed using oscillometric equipment. Measurements of body weight, height, waist circumference, and skinfold thickness were performed. Somatic maturation was estimated by the age at peak height velocity. Behavioral and hereditary variables were obtained using a questionnaire. Early-maturing adolescents had the highest prevalence of high BP (28%; 95% confidence interval, 24.6-33.5) compared with other maturational groups (P=.003). In late-maturing adolescents, the variables associated with BP were paternal hypertension (systolic BP: ß=4.9; diastolic BP: ß=5.3) and early physical activity (systolic BP: ß=-4.0; diastolic DBP: ß=-3.6). In average-maturing adolescents, waist circumference (systolic BP: ß=0.3), body mass index (diastolic BP: ß=0.5), and mother's hypertension (diastolic BP: ß=1.8) were positively related to BP. In early-maturing adolescents, only waist circumference (systolic BP: ß=0.3; diastolic BP: ß=0.3) was associated with BP. The authors conclude that the prevalence of high BP is greater in adolescents with early maturity and the outcome appears to be related to biological indicators in this group. On the other hand, in late-maturing adolescents, behavioral and hereditary variables are more related to BP.

Analysis of the training load during a hypertrophy-type resistance training programme in men and women.

The purpose of this study was to analyze the specific training load during a resistance training (RT) programme designed to increase muscular hypertrophy in men and women. Thirty-four women (22.7 ± 4.1 years, 58.8 ± 11.9 kg, 162.6 ± 6.2 cm and 22.1 ± 3.6 kg.m(-2)) and 30 men (22.7 ± 4.4 years, 68.4 ± 9.0 kg, 174.5 ± 6.6 cm and 22.5 ± 2.4 kg.m(-2)) underwent a supervised RT programme that was divided into two phases of 8 weeks each. Training consisted of 10-12 exercises performed with three sets of 8-12 repetitions at repetition maximum resistances performed 3 times per week on nonconsecutive days. There was a significant (P < 0.05) main effect for gender by time interaction for average training load of all the exercises performed in the first 8 weeks of RT with women showing a higher relative increase than men (+43.6% vs. +32.5%, respectively). This result was not observed during the second 8-week phase of the RT programme during which no significant gender by time interaction (P > 0.05) was shown with both genders having a similar relative increase (+28.7% vs. +24.3%, respectively). Women had a higher increase than men in specific average training load of the upper limb exercises during both the first 8 weeks of training (+30.2% vs. +26.6%, respectively) and the second 8 weeks of training (+31.1% vs. +25.3%, respectively). We conclude that the adaptation in specific training load is influenced by gender.

Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience.

The purpose of this study was to analyze the effects of a progressive resistance training (RT) program on C-reactive protein (CRP), blood glucose (GLU), and lipid profile in older women with differing levels of RT experience. Sixty-five older women (68.9 ± 6.1 years, 67.1 ± 13.1 kg) were separated according to RT experience: an advanced group composed by 35 participants who previously carried out 24 weeks of RT and a novice group composed by 30 participants without previous experience in RT (n = 30). Both groups performed a RT program comprised of eight exercises targeting all the major muscles. Training was carried out 3 days/week for 8 weeks. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), GLU, and CRP concentrations were determined pre- and post- intervention after 12 h fasting. A significant group by time interaction (P < 0.05) for the TC (novice = -1.9% vs. advanced = 1.0%), and CRP (novice = -22.9% vs. advanced = -54.5%) was observed. A main effect of time (P < 0.05) was identified for the GLU (novice = -2.6% vs. advanced = -6.6%), TG (novice = -12.9% vs. advanced = -5.7%), HDL-C (novice = +6.7% vs. advanced = +2.6%), and LDL-C (novice = -34.0% vs. advanced = -25.4%). These results suggest that RT improves the metabolic profile of older women and that training for a longer period of time seems to produce more pronounced reductions mainly on CRP.

Twenty minutes of post-exercise hypotension are enough to predict chronic blood pressure reduction induced by resistance training in older women

AIM: This study investigated the correlation between post-exercise hypotension (PEH) and chronic blood pressure (BP) reduction in older women after a resistance training (RT) program. METHODS: Twenty-five older women (≥60 years) performed a RT program for 8 weeks, 3x/week consisting of 3 sets of 8-12 repetitions maximum in 8 exercises. Acute and chronic BP measurements were performed using automatic equipment, in which acute BP was measured before and after 10, 20, 30, 40, 50 and 60 min following the sixth exercise session, while chronic BP was measured pre and post-training. RESULTS: Significant decrease for systolic blood pressure (SBP) was observed after the intervention period, however, the diastolic blood pressure (DBP) did not change. To acute changes in BP, SBP decreased at all times after a single RT session, while DBP increased after 40 min. The reduction for SBP after a single RT session at baseline showed positive and significant correlations with the reductions in basal SBP observed after the 8 weeks of RT, the strongest correlations were observed at 20 min. A linear relationship between the magnitude of change in chronic SBP and the 20 min for acute SBP, and 30 min for acute DBP of post-exercise was observed. CONCLUSION: The results suggest that acute BP lowering after RT session is a reliable predictor of chronic BP response to exercise training, and 20 min of resting, after RT training, is enough to indicate chronic response of BP as this measure was highly associated with chronic BP lowering in older women.(AU)

Experienciando a hospitalização com a presença da família: um cuidado que possibilita conforto / The presence of the patientïs family beside him during the hospitalization

Com o objetivo de desvelar se, para o paciente, a presença da família junto a ele na hospitalização interfere na vivência de conforto durante esse período, desenvolvi este estudo que utilizou a fenomenologia como trajetória metodológica...