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Parasite Immunol ; 46(5): e13037, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38720446

RESUMO

The treatment for visceral leishmaniasis (VL) causes toxicity in patients, entails high cost and/or leads to the emergence of resistant strains. No human vaccine exists, and diagnosis presents problems related to the sensitivity or specificity of the tests. Here, we tested two phage clones, B1 and D11, which were shown to be protective against Leishmania infantum infection in a murine model as immunotherapeutics to treat mice infected with this parasite species. The phages were used alone or with amphotericin B (AmpB), while other mice received saline, AmpB, a wild-type phage (WTP) or WTP/AmpB. Results showed that the B1/AmpB and D11/AmpB combinations induced polarised Th1-type cellular and humoral responses, which were primed by high levels of parasite-specific IFN-γ, IL-12, TNF-α, nitrite and IgG2a antibodies, which reflected in significant reductions in the parasite load in distinct organs of the animals when analyses were performed 1 and 30 days after the treatments. Reduced organic toxicity was also found in these animals, as compared with the controls. In conclusion, preliminary data suggest the potential of the B1/AmpB and D11/AmpB combinations as immunotherapeutics against L. infantum infection.


Assuntos
Anfotericina B , Anticorpos Antiprotozoários , Imunoterapia , Leishmania infantum , Leishmaniose Visceral , Camundongos Endogâmicos BALB C , Leishmaniose Visceral/imunologia , Leishmaniose Visceral/tratamento farmacológico , Animais , Anfotericina B/uso terapêutico , Anfotericina B/administração & dosagem , Anticorpos Antiprotozoários/sangue , Leishmania infantum/imunologia , Leishmania infantum/efeitos dos fármacos , Camundongos , Imunoterapia/métodos , Feminino , Antiprotozoários/uso terapêutico , Antiprotozoários/administração & dosagem , Imunoglobulina G/sangue , Carga Parasitária , Modelos Animais de Doenças , Técnicas de Visualização da Superfície Celular , Citocinas/metabolismo , Células Th1/imunologia
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