Detalhe da pesquisa
1.
Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease.
Neurobiol Dis
; 186: 106285, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37690676
2.
Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy.
Neurobiol Dis
; 178: 106010, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36702318
3.
Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease.
Proc Natl Acad Sci U S A
; 115(28): E6428-E6436, 2018 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941560
4.
Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease.
Neurobiol Dis
; 127: 163-177, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30849508
5.
Corrigendum to " Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy Body Disease" [Neurobiology of Disease127 (2019) 163-177].
Neurobiol Dis
; 191: 106397, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216383
6.
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.
Neurobiol Dis
; 132: 104582, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445162
7.
Effects of single and combined immunotherapy approach targeting amyloid ß protein and α-synuclein in a dementia with Lewy bodies-like model.
Alzheimers Dement
; 15(9): 1133-1148, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31378574
8.
Alterations in brain TREM2 and Amyloid-ß levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy.
J Neurochem
; 147(6): 784-802, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30152135
9.
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.
Hum Mol Genet
; 25(6): 1100-15, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26740557
10.
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.
Hum Mol Genet
; 25(13): 2645-2660, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27126635
11.
Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders.
Acta Neuropathol
; 136(1): 69-87, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29934874
12.
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.
Nature
; 489(7415): 304-8, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22972301
13.
Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.
J Neurosci
; 36(30): 7971-84, 2016 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27466341
14.
Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease.
J Biol Chem
; 291(4): 1905-1920, 2016 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26620558
15.
The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration.
J Neurovirol
; 23(2): 290-303, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28105557
16.
A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.
Brain
; 139(Pt 12): 3217-3236, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27679481
17.
HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders.
J Neurosci
; 35(5): 1921-38, 2015 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25653352
18.
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.
Neurobiol Dis
; 86: 154-69, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26611103
19.
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
J Neurosci
; 34(28): 9441-54, 2014 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25009275
20.
A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.
J Biol Chem
; 289(25): 17917-31, 2014 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24825898