Detalhe da pesquisa
1.
The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1.
Gastroenterology
; 165(1): 228-243.e2, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37059338
2.
The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
J Biol Chem
; 294(49): 18698-18713, 2019 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31659122
3.
Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.
Liver Int
; 40(10): 2455-2468, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32558183
4.
Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.
Hepatology
; 67(1): 247-259, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28802066
5.
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A.
J Biol Chem
; 292(12): 4833-4846, 2017 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28184004
6.
Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.
J Hepatol
; 69(3): 676-686, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29802947
7.
Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis.
Lab Invest
; 97(11): 1385-1396, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28892096
8.
Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis.
Hepatology
; 63(1): 185-96, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26044703
9.
Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression.
Am J Pathol
; 184(1): 110-21, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24211536
10.
Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis.
Hepatology
; 59(6): 2263-75, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24390753
11.
Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis.
Lab Invest
; 94(10): 1126-33, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25046437
12.
Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography.
Lab Invest
; 93(6): 733-43, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23588707
13.
The dynamic biliary epithelia: molecules, pathways, and disease.
J Hepatol
; 58(3): 575-82, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23085249
14.
Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling.
Am J Physiol Gastrointest Liver Physiol
; 304(11): G1013-24, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23578785
15.
Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis.
Hepatology
; 56(2): 687-97, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22383162
16.
Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation.
J Biol Chem
; 286(35): 30352-30360, 2011 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21757746
17.
Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs.
Am J Pathol
; 179(4): 1851-60, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21854740
18.
NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection.
J Biol Chem
; 285(1): 216-25, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19903813
19.
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.
J Clin Invest
; 118(11): 3714-24, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18949056
20.
Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.
Gastroenterology
; 139(1): 304-14.e2, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20399209