Quantitative regional blood-flow analysis and its clinical application during routine bone-scanning.

A method of combined dynamic and static bone-imaging using technetium 99-labeled phosphonate is described. During the dynamic part of the study, immediately after intravenous injection of the radionuclide, counts per second were recorded over a period of time for analogous regions of normal and diseased bones. The counts per second then were plotted against time to give time-activity curves for each of these regions. The time-activity curves were divided into arterial, venous, and blood-pool phases. Each phase was integrated and then divided by the time-span of the phase to give average total counts per unit of time. The values of these normalized integrals were directly proportional to the blood flow to the regions of bone from which they were calculated. Ratios of normalized integrals from the analogous regions of the diseased bone to the normal bone were calculated to determine whether the blood flow to the diseased bone was decreased or increased. Static images of the bone structures analyzed during the dynamic portion of the study were obtained two hours after the initial injection of the radionuclide and the total number of counts for analogous regions on the static images of the normal and diseased bones were static images of the normal and diseased bones were recorded. The total number of counts for each region was divided by the area of that region to give average total counts. Ratios of the normalized counts were calculated for analogous regions of the diseased to the normal bone to determine whether there was an increase or decrease in concentration of the radionuclide. The method first was used to evaluate hip pain in children and adults. In order to recognize an abnormal result, mean values and two standard deviations were calculated for the dynamic and static ratios in a group of fifty patients who had no clinical complaints about the hips or lower extremities. Any ratios outside of the range of two standard deviations were considered abnormal. The method later was used to evaluate other bones, such as the tibia and humerus. Any value for the ratios beyond 1 +/- 0.20 was considered abnormal for these studies.

Ga-67 studies in a patient with acquired immunodeficiency syndrome and disseminated mycobacterial infection.

A well-documented case of acquired immunodeficiency syndrome (AIDS) with diffuse lymphadenopathy and disseminated mycobacteriosis in whom serial Ga-67 studies were performed is presented.

Metastatic intraocular carcinoma: clinicopathologic study of a case.

This case report describes the fluorescein angiography, the radioactive scintigraphy, and the pathologic findings of an intraocular metastasis from bronchogenic carcinoma which occurred in a 64-year-old white man. In spite of extensive studies, no definitive differential diagnosis between primary and secondary eye lesion could be established before enucleation for intractable pain. This case illustrates that presently available methods are not adequate for correct differential diagnosis in such cases.

Thallium-201 myocardial imaging in patients on chronic hemodialysis.

10 long-term hemodialysis patients had immediate and redistribution thallium-201 myocardial imaging performed after a course of hemodialysis. Subjects had EKGs done on the same day before and after dialysis. 3 of the 10 subjects had resting thallium-201 myocardial imaging obtained on non-dialysis days. 60% of the electrocardiograms showed changes with dialysis. All 13 thallium studies were abnormal, showing multiple transient filling defects at rest. Most subjects had permanent filling defects as well. It is concluded that hemodialysis patients have a high frequency of abnormal thallium-201 myocardial images at rest. The cause of these abnormal studies is uncertain.