RESUMO
Based on 1,2-O-isopropylidene-sn-glycerol five chiral building blocks containing differently modified glycerol residues were required for the synthesis of the target molecule 2. One of these building blocks is diacylglyceryl beta-gentiobioside carrying a phosphite residue at 6b-O position. Ligation of these five building blocks led to the desired glycerol phosphate backbone to which d-alanyl residues were attached, thus generating after O-deprotection the target molecule 2, a bisamphiphilic structural variant of Staphylococcus aureus LTA. This compound displayed higher potency in terms of cytokine release by human blood leukocytes than the monoamphiphilic variant LTA.
Assuntos
Diglicerídeos/química , Lipopolissacarídeos/química , Staphylococcus aureus/química , Ácidos Teicoicos/química , Configuração de Carboidratos , Sequência de Carboidratos , Citocinas/biossíntese , Citocinas/efeitos dos fármacos , Relação Dose-Resposta a Droga , Humanos , Leucócitos/efeitos dos fármacos , Lipopolissacarídeos/síntese química , Lipopolissacarídeos/farmacologia , Conformação Molecular , Dados de Sequência Molecular , Estereoisomerismo , Relação Estrutura-Atividade , Ácidos Teicoicos/síntese química , Ácidos Teicoicos/farmacologiaRESUMO
The possibility of compensating for the aberrations of an imaging lens in digital holography is outlined theoretically. The principle is demonstrated with a Mach-Zehnder arrangement and transilluminated objects. Diffraction-limited resolution can be obtained with a plano-convex lens. Amplitude and phase objects were imaged.