Neurolytic effects of ampicillin on the rat infraorbital nerve.

PURPOSE: The aim of this study was to investigate the histomorphological changes of the infraorbital nerve of rats treated with ampicillin. MATERIALS AND METHODS: The infraorbital nerve was approached through the infraorbital foramen, and 0.01 ml of ampicillin dissolved in distilled water was injected taking care not to damage the nerve. Saline solution was used in control animals. Nerves were dissected and after routine histology processing analysed by light microscopy. RESULTS: Cross-section of the nerve treated with ampicillin showed damaged axons with disintegration of heavily myelinated fibres, while thinly myelinated fibres remain unaffected. In the saline group, no damage was observed. The signs of regeneration of the damaged infraorbital nerves were detected on the fourth post-operative week. CONCLUSION: Ampicillin can cause peripheral nerve damage when injected perineurally.

Comprehensive surgical. Orthodontic treatment of class III malocclusion in cleft patient involving minimally invasive surgery Case report and literature review.

AIM: Surgical and orthodontic treatment of a teenage cleft patient. CASE REPORT: Authors describe the case of a 13 year old female cleft patient presented with class III malocclusion RESULT: The patient underwent comprehensive surgical secondary bone grafting and orthodontic treatment. Stable skeletal and occlusal class I relationship was achived and maintained in the post treatment observation period till the age of 16. DISCUSSION: Although several authors suggests primary gingivoperiosteoplasty, other advocates that such early intervention can cause later restrictions in maxillary growth. For alveolar reconstruction, maxillary growth and dental age were the main considerations in determining the timing of surgical intervention. CONCLUSION: This case showed that borderline cases of complex dentoalveolar and skeletal anomaly in cleft patients could be successfully treated with comprehensive secondary bone grafting and orthodontic treatment thus avoiding the need for orthognatic surgery. KEY WORDS: Alveolar bone grafting, Cleft, Malocclusion.

The effects of streptomycin on autotomy.

Thirty-six rats with sciatic nerve transections and autotomy scores 1-2 were divided into 3 groups. Two groups were re-operated and injected with streptomycin sulphate or saline into the polyethylene tube around the neuroma. In the third group, streptomycin was injected at the sciatic nerve, extraneurally, proximal to the tube. Streptomycin injected into the polyethylene tube suppressed autotomy scores during the entire postinjection period. At the eighth postinjection week, none of the rats from this group reached the maximal autotomy score.

Effects of streptomycin on the rat infraorbital nerve.

INTRODUCTION: It has been reported that streptomycin can have anti-neuralgic effects. However, the mode of action is unknown. This article was intended to investigate eventual neurolytic effects of streptomycin on peripheral nerves when applied topically. MATERIAL AND METHOD: The rat infraorbital nerve, used as the experimental model, was treated with 0.01 ml of streptomycin sulphate dissolved either in distilled water or in lidocaine via an infraorbital perineural injection. Saline was used in control animals. RESULTS: Cross-sections of the nerve, a week following treatment with streptomycin, revealed damaged axons with disintegration of both heavily and thinly myelinated fibres. Signs of regeneration were detected from the fourth postoperative week on. In control rats no damage was observed. CONCLUSION: Streptomycin can cause peripheral nerve damage when injected perineurally. These morphological changes may be responsible for anti-neuralgic effects of streptomycin.

Resonance frequency analysis as a reliable criterion for early loading of sandblasted/acid-etched active surface implants placed by the osteotome sinus floor elevation technique.

PURPOSE: This study was intended to investigate, through resonance frequency analysis (RFA), the stability of implants placed in an early loading protocol via the osteotome sinus floor elevation technique in the posterior maxilla. All implants featured a sandblasted/acid-etched active surface. MATERIALS AND METHODS: An early loading protocol was considered for patients in whom implants with a sandblasted, large-grit/acid-etched active surface (SLActive) were placed in the posterior maxilla by the osteotome sinus floor elevation technique. Implant stability, which was measured by RFA at surgery and at weekly intervals for the following 6 weeks, was used as the most significant inclusion criterion. At the end of the stability observation period, only implants with a stability quotient of 65 or higher were loaded. Implants were followed for 2 years. RESULTS: Twenty-seven patients received 42 implants, 40 of which were subjected to an early loading protocol 6 weeks after placement. Two years after loading, all 40 implants were surviving, without clinically or radiographically detectible complications. CONCLUSION: An early loading protocol can be used for SLActive implants placed in the posterior maxilla via the osteotome sinus floor elevation technique if their stability is confirmed by RFA.