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1.
Pediatr Dev Pathol ; 25(6): 611-623, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36120950

RESUMO

Background: Myhre syndrome, caused by pathogenic variants in SMAD4, is characterized by compact body habitus with short stature, distinctive craniofacial appearance, stiff skin, cardiovascular abnormalities (valve stenosis, coarctation, hypoplasia, or stenosis of aorta), effusions of potential spaces (pericardium, pleura, peritoneum), restricted movement of the joints (including thorax), and hearing loss. Lung and airway disease has been reported, but not always well-defined, to include interstitial lung disease, large airway obstruction, and pulmonary arterial hypertension. Excessive fibroproliferation of tissues especially following trauma or surgical instrumentation has been recognized, although these may also present spontaneously. Method: We report the pathologic features of 1 new patient with progressive choanal stenosis, and 22 literature cases, including the expanded history of 5 patients (3 who died). Results: Examination of patient tissues documents cellular fibroproliferation and deposition of excessive extracellular matrix explaining some of the observed clinical features of Myhre syndrome. Conclusion: Excessive fibrosis is noted in multiple tissues, especially heart, lung, and upper and lower airways. Our research provides the first systematic review to provide a knowledge base of gross and pathologic findings in Myhre syndrome.


Assuntos
Mutação com Ganho de Função , Deformidades Congênitas da Mão , Masculino , Humanos , Constrição Patológica , Deformidades Congênitas da Mão/diagnóstico , Deformidades Congênitas da Mão/patologia , Fácies , Proteína Smad4/genética
2.
Clin Genet ; 100(4): 468-477, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34212383

RESUMO

We describe the clinical features of nine unrelated individuals with rare de novo missense or in-frame deletions/duplications within the "HX motif" of exon 7 of ATN1. We previously proposed that individuals with such variants should be considered as being affected by the syndromic condition of congenital hypotonia, epilepsy, developmental delay, and digital anomalies (CHEDDA), distinct from dentatorubral-pallidoluysian atrophy (DRPLA) secondary to expansion variants in exon 5 of ATN1. We confirm that the universal phenotypic features of CHEDDA are distinctive facial features and global developmental delay. Infantile hypotonia and minor hand and feet differences are common and can present as arthrogryposis. Common comorbidities include severe feeding difficulties, often requiring gastrostomy support, as well as visual and hearing impairments. Epilepsy and congenital malformations of the brain, heart, and genitourinary systems are frequent but not universal. Our study confirms the clinical entity of CHEDDA secondary to a mutational signature restricted to exon 7 of ATN1. We propose a clinical schedule for assessment upon diagnosis, surveillance, and early intervention including the potential of neuroimaging for prognostication.


Assuntos
Predisposição Genética para Doença , Mutação , Proteínas do Tecido Nervoso/genética , Transtornos do Neurodesenvolvimento/diagnóstico , Transtornos do Neurodesenvolvimento/genética , Fenótipo , Pré-Escolar , Fácies , Feminino , Estudos de Associação Genética , Humanos , Masculino , Síndrome
3.
Am J Med Genet A ; 182(2): 328-337, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31837202

RESUMO

Myhre syndrome is an increasingly diagnosed rare syndrome that is caused by one of two specific heterozygous gain-of-function pathogenic variants in SMAD4. The phenotype includes short stature, characteristic facial appearance, hearing loss, laryngotracheal stenosis, arthritis, skeletal abnormalities, learning and social challenges, distinctive cardiovascular defects, and a striking fibroproliferative response in the ear canals, airways, and serosal cavities (peritoneum, pleura, pericardium). Confirmation of the clinical diagnosis is usually prompted by the characteristic appearance with developmental delay and autistic-like behavior using targeted gene sequencing or by whole exome sequencing. We describe six patients (two not previously reported) with molecularly confirmed Myhre syndrome and neoplasia. Loss-of-function pathogenic variants in SMAD4 cause juvenile polyposis syndrome and we hypothesize that the gain-of-function pathogenic variants observed in Myhre syndrome may contribute to neoplasia in the patients reported herein. The frequency of neoplasia (9.8%, 6/61) in this series (two new, four reported patients) and endometrial cancer (8.8%, 3/34, mean age 40 years) in patients with Myhre syndrome, raises the possibility of cancer susceptibility in these patients. We alert clinicians to the possibility of detecting this syndrome when cancer screening panels are used. We propose that patients with Myhre syndrome are more susceptible to neoplasia, encourage increased awareness, and suggest enhanced clinical monitoring.


Assuntos
Criptorquidismo/genética , Neoplasias do Endométrio/genética , Transtornos do Crescimento/genética , Deformidades Congênitas da Mão/genética , Deficiência Intelectual/genética , Neoplasias/genética , Proteína Smad4/genética , Adulto , Criptorquidismo/complicações , Criptorquidismo/patologia , Neoplasias do Endométrio/complicações , Neoplasias do Endométrio/patologia , Fácies , Feminino , Mutação com Ganho de Função/genética , Transtornos do Crescimento/complicações , Transtornos do Crescimento/patologia , Deformidades Congênitas da Mão/complicações , Deformidades Congênitas da Mão/patologia , Heterozigoto , Humanos , Deficiência Intelectual/complicações , Deficiência Intelectual/patologia , Masculino , Pessoa de Meia-Idade , Mutação/genética , Neoplasias/complicações , Neoplasias/patologia , Fenótipo , Fator de Crescimento Transformador beta/genética , Sequenciamento do Exoma
4.
Am J Med Genet A ; 179(5): 808-812, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30838730

RESUMO

ARID2 loss-of-function is associated with a rare genetic disorder characterized in 14 reported patients to date. ARID2 encodes a member of the SWItch/sucrose non-fermentable chromatin remodeling complex. Other genes encoding subunits of this complex, such as ARID1A, ARID1B, and SMARCA2, are mutated in association with Coffin-Siris syndrome (CSS) and Nicolaides Baraitser syndrome (NCBRS) phenotypes. Previously reported ARID2 mutations manifested clinically with a CSS-like phenotype including intellectual disability, coarsened facial features, fifth toenail hypoplasia, and other recognizable dysmorphisms. However, heterogeneity exists between previously reported patients with some patients showing more overlapping features with NCBRS. Herein, we present a patient with a novel disease-causing ARID2 loss-of-function mutation. His clinical features included intellectual disability, coarse and dysmorphic facial features, toenail hypoplasia, ADHD, short stature, and delayed development consistent with prior reports. Our patient also presented with previously unreported clinical findings including ophthalmologic involvement, persistent fetal fingertip and toetip pads, and diffuse hyperpigmentary and hypopigmentary changes sparing his face, palms, and soles. The anomalous skin findings are particularly of interest given prior literature outlining the role of ARID2 in melanocyte homeostasis and melanoma. This clinical report and review of the literature is further affirming of the characteristic symptoms and expands the phenotype of this newly described and rare syndrome.


Assuntos
Predisposição Genética para Doença , Deficiência Intelectual/diagnóstico , Deficiência Intelectual/genética , Mutação com Perda de Função , Fenótipo , Pigmentação da Pele/genética , Fatores de Transcrição/genética , Criança , Proteínas Cromossômicas não Histona , Fácies , Estudos de Associação Genética , Variação Genética , Humanos , Masculino , Radiografia
5.
Am J Med Genet A ; 179(7): 1270-1275, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31148362

RESUMO

PIGQ (OMIM *605754) encodes phosphatidylinositol glycan biosynthesis class Q (PIGQ) and is required for proper functioning of an N-acetylglucosamine transferase complex in a similar manner to the more established PIGA, PIGC, and PIGH. There are two previous patients reported with homozygous and apparently deleterious PIGQ mutations. Here, we provide the first detailed clinical report of a patient with heterozygous deleterious mutations associated with glycosylphosphatidylinositol-anchored protein (GPI-AP) biosynthesis deficiency. Our patient died at 10 months of age. The rare skeletal findings in this disorder expand the differential diagnosis of long bone radiolucent lesions and sphenoid wing dysplasia. This clinical report describes a new and rare disorder-PIGQ GPI-AP biosynthesis deficiency syndrome.


Assuntos
Anormalidades Múltiplas/genética , Doenças do Desenvolvimento Ósseo/genética , Glicosilfosfatidilinositóis/deficiência , Proteínas de Membrana/genética , Hipotonia Muscular/genética , Mutação , Convulsões/genética , Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/metabolismo , Anormalidades Múltiplas/patologia , Doenças do Desenvolvimento Ósseo/diagnóstico , Doenças do Desenvolvimento Ósseo/metabolismo , Doenças do Desenvolvimento Ósseo/patologia , Evolução Fatal , Expressão Gênica , Glicosilfosfatidilinositóis/genética , Glicosilfosfatidilinositóis/metabolismo , Heterozigoto , Humanos , Lactente , Masculino , Proteínas de Membrana/deficiência , Hipotonia Muscular/diagnóstico , Hipotonia Muscular/metabolismo , Hipotonia Muscular/patologia , Fenótipo , Convulsões/diagnóstico , Convulsões/metabolismo , Convulsões/patologia , Osso Esfenoide/metabolismo , Osso Esfenoide/patologia , Síndrome , Sequenciamento do Exoma
6.
Hemoglobin ; 43(3): 207-209, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31387435

RESUMO

We describe here a previously unreported hemoglobin (Hb) variant, Hb Gibbon [ß124(H2)Pro→Thr (HBB: c.373C>A, p.P125T)] detected by newborn Hb screening in a term male with no family history for hemoglobinopathy or other screening abnormalities. This missense mutation produces a ß-globin chain variant that was detected by high performance liquid chromatography (HPLC) methods, but is silent by capillary electrophoresis (CE). DNA sequencing studies revealed that his father was also a heterozygote for this mutation. Neither has abnormalities on complete blood count (CBC) or any symptomatology.


Assuntos
Alelos , Substituição de Aminoácidos , Doenças Assintomáticas , Hemoglobinopatias/diagnóstico , Hemoglobinopatias/genética , Globinas beta/genética , Cromatografia Líquida de Alta Pressão , Análise Mutacional de DNA , Genótipo , Hemoglobinas Anormais/genética , Humanos , Recém-Nascido , Triagem Neonatal , Globinas beta/análise , Globinas beta/metabolismo
7.
Am J Med Genet A ; 176(4): 1011-1014, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29575632

RESUMO

We describe a neonatal patient with fixed dilated pupils and pulmonary, bladder, and bowel dysfunction suspicious for the presence of ACTA2 R179 mediated multisystemic smooth muscle dysfunction syndrome. Whole exome sequencing revealed compound heterozygous mutations in MYH11 after ACTA2 specific testing revealed no abnormalities. The child lived until 18 months of age and represents the only reported case of an MYH11 compound heterozygote with widespread smooth muscle dysfunction.


Assuntos
Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/genética , Genes Recessivos , Músculo Liso/fisiopatologia , Mutação , Cadeias Pesadas de Miosina/genética , Fenótipo , Alelos , Substituição de Aminoácidos , Análise Mutacional de DNA , Diagnóstico por Imagem , Evolução Fatal , Estudos de Associação Genética , Heterozigoto , Humanos , Lactente , Masculino , Síndrome
8.
Am J Med Genet A ; 170(9): 2416-20, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27338032

RESUMO

Duplications of the long arm of chromosome 6 have been previously reported in a limited number of patients; however, most reported duplications encompass regions of chromosome 6 distal to band q21. Duplications restricted to the proximal portion of 6q are rare. We report an 8-year-old male with a 16.4 megabase (Mb) tandem duplication of chromosome 6q14.1q16.1 (chr6:78950191-95395865; hg19) who exhibited dysmorphic facial features, seizures, global developmental delay, intellectual disability, autism spectrum disorder, sensorineural hearing loss, and immune deficiency. This patient refines and potentially expands the current, poorly-characterized phenotype associated with duplication of this proximal 6q region. We recommend a low threshold for a hearing evaluation beyond newborn screening and for pursuing an immune work-up in patients with similar 6q duplications. © 2016 Wiley Periodicals, Inc.


Assuntos
Duplicação Cromossômica , Cromossomos Humanos Par 6 , Estudos de Associação Genética , Fenótipo , Sequências de Repetição em Tandem , Anormalidades Múltiplas , Criança , Bandeamento Cromossômico , Hibridização Genômica Comparativa , Fácies , Genótipo , Humanos , Masculino , Análise de Sequência com Séries de Oligonucleotídeos , Polimorfismo de Nucleotídeo Único
9.
Genet Med ; 17(11): 875-9, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25590977

RESUMO

PURPOSE: The identification of clinically relevant genomic dosage anomalies assists in accurate diagnosis, prognosis, and medical management of affected individuals. Technological advancements within the field, such as the advent of microarray, have markedly increased the resolution of detection; however, clinical laboratories have maintained conventional techniques for confirmation of genomic imbalances identified by microarray to ensure diagnostic accuracy. In recent years the utility of this confirmatory testing of large-scale aberrations has been questioned but has not been scientifically addressed. METHODS: We retrospectively reviewed 519 laboratory cases with genomic imbalances meeting reportable criteria by microarray and subsequently confirmed with a second technology, primarily fluorescence in situ hybridization. RESULTS: All genomic imbalances meeting reportable criteria detected by microarray were confirmed with a second technology. Microarray analysis generated no false-positive results. CONCLUSION: Confirmatory testing of large-scale genomic imbalances (deletion of ≥150 kb, duplication of ≥500 kb) solely for the purpose of microarray verification may be unwarranted. In some cases, however, adjunct testing is necessary to overcome limitations inherent to microarray. A recommended clinical strategy for adjunct testing following identified genomic imbalances using microarray is detailed.


Assuntos
Desequilíbrio Alélico , Genômica , Variações do Número de Cópias de DNA , Dosagem de Genes , Duplicação Gênica , Genoma Humano , Genômica/métodos , Genômica/normas , Humanos , Hibridização in Situ Fluorescente , Análise de Sequência com Séries de Oligonucleotídeos/métodos , Polimorfismo de Nucleotídeo Único , Reprodutibilidade dos Testes , Estudos Retrospectivos , Deleção de Sequência
10.
Am J Med Genet A ; 167A(9): 2168-75, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25914130

RESUMO

The coexistence of two or more distinct genetic conditions is known to be a rare phenomenon. Full chromosome aneuploidies can be associated with a broad variety of cytogenetic abnormalities or single gene disorders resulting in phenotypic modifications that confuse the diagnostic process. We present six patients with primary aneuploidies and a suspected or confirmed secondary genetic diagnosis or unusual birth defect. Among the cases included, we report the first patients with concurrent Down syndrome in combination with Prader-Willi, Craniofacial Microsomia, and Stickler syndromes. We also describe only the second reported case of a neonate with Down syndrome and Marfan syndrome. In all cases, the unusual clinical presentations lead to further molecular cytogenetic studies as well as single or multi-gene molecular evaluations. We make emphasis on the importance of entertaining the possibility of coexistent diagnoses when the phenotype is not what is expected for aneuploidies rather than attributing the unusual findings to rare or unreported associations of the primary aneuploidy.


Assuntos
Transtornos Cromossômicos/genética , Anormalidades Congênitas/genética , Doenças Genéticas Inatas/genética , Aneuploidia , Criança , Pré-Escolar , Aberrações Cromossômicas , Comorbidade , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Fenótipo
11.
Am J Med Genet A ; 167A(12): 2893-901, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26420300

RESUMO

Myhre syndrome, a connective tissue disorder characterized by deafness, restricted joint movement, compact body habitus, and distinctive craniofacial and skeletal features, is caused by heterozygous mutations in SMAD4. Cardiac manifestations reported to date have included patent ductus arteriosus, septal defects, aortic coarctation and pericarditis. We present five previously unreported patients with Myhre syndrome. Despite varied clinical phenotypes all had significant cardiac and/or pulmonary pathology and abnormal wound healing. Included herein is the first report of cardiac transplantation in patients with Myhre syndrome. A progressive and markedly abnormal fibroproliferative response to surgical intervention is a newly delineated complication that occurred in all patients and contributes to our understanding of the natural history of this disorder. We recommend routine cardiopulmonary surveillance for patients with Myhre syndrome. Surgical intervention should be approached with extreme caution and with as little invasion as possible as the propensity to develop fibrosis/scar tissue is dramatic and can cause significant morbidity and mortality.


Assuntos
Criptorquidismo/etiologia , Criptorquidismo/terapia , Transtornos do Crescimento/etiologia , Transtornos do Crescimento/terapia , Deformidades Congênitas da Mão/etiologia , Deformidades Congênitas da Mão/terapia , Cardiopatias/cirurgia , Deficiência Intelectual/etiologia , Deficiência Intelectual/terapia , Criança , Criptorquidismo/complicações , Eletrocardiografia , Fácies , Feminino , Transtornos do Crescimento/complicações , Deformidades Congênitas da Mão/complicações , Transplante de Coração , Humanos , Deficiência Intelectual/complicações , Masculino , Mutação , Gravidez , Proteína Smad4/genética , Adulto Jovem
12.
Am J Med Genet A ; 164A(4): 1079-82, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24596125

RESUMO

Duplications of the long arm of chromosome 18 have been previously reported in patients with phenotypic findings similar to full trisomy 18. Trisomy 18 increases the risk for Wilms tumor and it is currently recommended that these patients undergo abdominal ultrasonography screening every 6 months. We report on nephroblastomatosis in a 27-month-old male with a 55 Mb duplication of chromosome 18q11.2-q23 (chr18:22693370-77982126, hg 19) and propose that the trisomy 18 tumor screening protocol could also benefit patients with large 18q duplications.


Assuntos
Cromossomos Humanos Par 18 , Macrossomia Fetal/genética , Duplicação Gênica , Trissomia/genética , Tumor de Wilms/genética , Pré-Escolar , Cromossomos Humanos Par 18/genética , Humanos , Masculino , Síndrome da Trissomía do Cromossomo 18
13.
Am J Med Genet A ; 164A(8): 2020-4, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24954807

RESUMO

Duplications of the terminal long arm of chromosome 20 are rare chromosomal anomalies. We report a male infant found on array comparative genomic hybridization analysis to have a 19.5 Mb duplication of chromosome 20q13.12-13.33, as well as an 886 kb deletion of 20p13 at 18,580-904,299 bp. This anomaly occurred as the recombinant product of a paternal pericentric inversion. There have been 23 reported clinical cases involving 20qter duplications; however, to our knowledge this is only the second reported patient with a paternal pericentric inversion resulting in 46,XY,rec(20)dup(20q). This patient shares many characteristics with previously described patients with 20qter duplications, including microphthalmia, anteverted nares, long ears, cleft palate, small chin, dimpled chin, cardiac malformations, and normal intrauterine growth. While there is variable morbidity in patients with terminal duplications of 20q, a review of previously reported patients and comparison to our patient's findings shows significant phenotypic similarity.


Assuntos
Deleção Cromossômica , Duplicação Cromossômica , Inversão Cromossômica , Cromossomos Humanos Par 20 , Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/genética , Mapeamento Cromossômico , Hibridização Genômica Comparativa , Humanos , Recém-Nascido , Cariotipagem , Masculino , Fenótipo
14.
Eur J Hum Genet ; 31(7): 824-833, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37130971

RESUMO

Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting 80% of cytosolic proteins in humans. The human essential gene, NAA10, encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetyltransferase A (NatA) complex, also including the accessory protein, NAA15. The full spectrum of human genetic variation in this pathway is currently unknown. Here we reveal the genetic landscape of variation in NAA10 and NAA15 in humans. Through a genotype-first approach, one clinician interviewed the parents of 56 individuals with NAA10 variants and 19 individuals with NAA15 variants, which were added to all known cases (N = 106 for NAA10 and N = 66 for NAA15). Although there is clinical overlap between the two syndromes, functional assessment demonstrates that the overall level of functioning for the probands with NAA10 variants is significantly lower than the probands with NAA15 variants. The phenotypic spectrum includes variable levels of intellectual disability, delayed milestones, autism spectrum disorder, craniofacial dysmorphology, cardiac anomalies, seizures, and visual abnormalities (including cortical visual impairment and microphthalmia). One female with the p.Arg83Cys variant and one female with an NAA15 frameshift variant both have microphthalmia. The frameshift variants located toward the C-terminal end of NAA10 have much less impact on overall functioning, whereas the females with the p.Arg83Cys missense in NAA10 have substantial impairment. The overall data are consistent with a phenotypic spectrum for these alleles, involving multiple organ systems, thus revealing the widespread effect of alterations of the NTA pathway in humans.


Assuntos
Transtorno do Espectro Autista , Deficiência Intelectual , Microftalmia , Humanos , Feminino , Síndrome , Acetiltransferase N-Terminal E/genética , Acetiltransferase N-Terminal E/metabolismo , Genótipo , Deficiência Intelectual/genética , Acetiltransferase N-Terminal A/genética , Acetiltransferase N-Terminal A/metabolismo
15.
Am J Med Genet A ; 158A(6): 1285-91, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22581587

RESUMO

Males with duplication of the Xq28 region, including methyl CpG-binding protein 2 (MECP2), exhibit a characteristic phenotype, including developmental delay, intellectual disability, limited or absent speech, limited or absent ambulation, and recurrent respiratory infections. We report six males with MECP2 duplications identified using array comparative genomic hybridization. The minimal sizes of these duplications range from ∼0.08 to 14.13 Mb, which, to the best of our knowledge, are respectively the smallest and largest minimal size duplications molecularly characterized to date. Adjunct metaphase fluorescence in situ hybridization analysis further classified these duplications as tandem or as products of complex chromosomal rearrangements. Specifically, one complex rearrangement was described as a der(12)t(X;12)(q28;q24.33), which is the first report of a translocation involving MECP2 on Xq and chromosome 12. The other complex rearrangement was described as a rec(X)dup(Xq)inv(X)(p22.32q28)mat. Synthesis of the dysmorphic features identified in individuals with rec(X) chromosomes, including deletions in the pseudoautosomal region 1 (PAR1) at Xp22.33/Yp11.3 and duplications of the distal Xq region including MECP2, revealed a high prevalence of undescended testes (7/8) and micropenis (3/8) in this cohort. Given that micropenis is rare in the general population, but present in 38% of individuals in this cohort, a dosage anomaly at one or both loci may be a significant risk factor for this condition. Therefore, we recommend microarray testing for patients with unexplained micropenis, particularly when accompanied by other phenotypic anomalies.


Assuntos
Cromossomos Humanos X , Duplicação Gênica , Proteína 2 de Ligação a Metil-CpG/genética , Translocação Genética , Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/genética , Criança , Pré-Escolar , Deficiências do Desenvolvimento/diagnóstico , Deficiências do Desenvolvimento/genética , Humanos , Deficiência Intelectual/diagnóstico , Deficiência Intelectual/genética , Masculino
16.
Am J Cardiol ; 140: 118-121, 2021 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-33144168

RESUMO

Patients with the Turner syndrome (TS) often have longer QT intervals compared with age-matched peers although the significance of this remains unknown. We sought to determine the degree, frequency and impact of QTc prolongation in patients with TS. A chart review of all patients with an electrocardiogram (ECG) and genetically proven TS was performed. Medications at the time of the ECG were reviewed and QTc calculated. Medications were classified according to QTc risk using www.crediblemeds.com. ECG parameters were compared with an age, gender, and cardiac lesion-matched control group. Over the 10-year period of review, 112 TS patients with a mean age of 34 ± 25 years underwent 226 ECGs. At least 1 QTc prolonging medication was prescribed in 81 (74%) patients. Longer QTc interval correlated with absence of y chromosomal material (p = 0.01), older age (p <0.0001), increased number of QTc prolonging and nonprolonging medications (p <0.0001 each). During the 7.0 ± 5.1 years of follow-up, no patient had ventricular arrhythmia or unexplained sudden death. QTc was significantly shorter in matched controls using either Bazett or Hodges formula (424 ± 16 ms vs 448 ± 28 ms, p <0.0001; and 414.8 ± 16 ms vs 424.2 ± 20 ms; p = 0.0002, respectively). However, there was no difference in the frequency of QTc prolongation >460 msec (2.8% vs 2.6%, p = 0.9). In conclusion, despite frequent use of QT-prolonging medications, ventricular arrhythmias are rare in TS.


Assuntos
Eletrocardiografia , Frequência Cardíaca/fisiologia , Síndrome do QT Longo/etiologia , Síndrome de Turner/complicações , Adulto , Feminino , Seguimentos , Humanos , Síndrome do QT Longo/diagnóstico , Síndrome do QT Longo/fisiopatologia , Masculino , Prognóstico , Estudos Retrospectivos , Síndrome de Turner/diagnóstico , Síndrome de Turner/fisiopatologia , Adulto Jovem
17.
Int J Cardiol ; 325: 127-131, 2021 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-33045278

RESUMO

BACKGROUND: The frequency of ascending aortic dissection in patients with Turner syndrome in the United States remains largely unknown with data surmised from published case reports or case series. Dissection of other vascular structures has only rarely been reported in this patient cohort. Recent European data identified aortic dissection to be a relatively rare event in a group of adult women with Turner syndrome. We sought to evaluate the prevalence of, and risk factors for, vascular dissection in women with Turner syndrome followed in the United States. METHOD: Retrospective review of all adult patients (age > 18 years) with Turner syndrome seen by any medical care provider within 2 medical systems covering a 5 state referral base was performed. Demographic, clinical, surgical and imaging variables of interest were recorded. RESULTS: Vascular dissection occurred in 16 (4.1%) of the 393 adult women and prophylactic aortic replacement occurred in 14 (3.5%). Only 35% of patients were under the care of a cardiologist with the remainder followed exclusively by other care providers. Vascular dissections occurred in the ascending & descending aorta as well as pulmonary artery and cerebral vessels. In addition to bicuspid aortic valve, and prior cardiac surgery, risk factors for vascular dissection included rural residence and lack of ongoing care by a cardiologist. CONCLUSION: Transition to adult cardiology subspecialty care is lacking in patients with Turner syndrome. Aortic dissection is not uncommon. Ongoing interaction with a cardiologist is essential to optimize cardiac outcomes in those with cardiac risk factors and may best be accomplished with centralized multidisciplinary clinics.


Assuntos
Dissecção Aórtica , Síndrome de Turner , Adulto , Dissecção Aórtica/diagnóstico por imagem , Dissecção Aórtica/epidemiologia , Dissecção Aórtica/etiologia , Aorta , Dissecação , Feminino , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Síndrome de Turner/complicações , Síndrome de Turner/diagnóstico , Síndrome de Turner/epidemiologia
18.
World J Pediatr Congenit Heart Surg ; 11(4): NP144-NP147, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29793379

RESUMO

Kawasaki disease can be difficult to diagnose in infants, putting them at higher risk for developing coronary artery dilatation. It can be even more difficult to diagnose in the setting of preexisting cardiac anomalies such as those found in Williams syndrome. We present a case of a three-month-old male with Williams syndrome with rapidly developing giant coronary aneurysms due to Kawasaki disease. This case demonstrates the importance of repeat echocardiography in diagnosing incomplete Kawasaki disease in infants. We speculate that elastin changes, as present in Williams syndrome, may put affected children at higher risk for development of giant coronary arteries should they acquire Kawasaki disease.


Assuntos
Aneurisma Coronário/etiologia , Síndrome de Linfonodos Mucocutâneos/diagnóstico , Síndrome de Williams/diagnóstico , Aneurisma Coronário/diagnóstico , Ecocardiografia , Humanos , Lactente , Masculino , Síndrome de Linfonodos Mucocutâneos/complicações , Tomografia Computadorizada por Raios X , Síndrome de Williams/complicações
19.
Congenit Heart Dis ; 14(5): 864-867, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31328377

RESUMO

OBJECTIVES: This study assessed the frequency and utility of echocardiographic examination in patients with all forms of Ehlers-Danlos syndrome and sought to identify clinical variables associated with an abnormal echocardiogram. DESIGN/SETTING: This was a retrospective study of all patients carrying a diagnosis of Ehlers-Danlos syndrome of any type who were evaluated by a pediatrician or pediatric subspecialist at a single tertiary medical center with an affiliated children's hospital during the period January 2013 to December 2018. PATIENTS: Chart review was performed on all patients carrying a diagnosis of Ehlers-Danlos syndrome in the electronic medical record. OUTCOME MEASURES: Data from genetics examination, cardiovascular examination where applicable, genetic test results when available, and echocardiography were recorded. RESULTS: Of 262 patients identified, echocardiography and cardiac evaluation were common occurring in 90% and 50% of patients with any form of Ehlers-Danlos syndrome. Cardiovascular complications occurred in 50% of patients with vascular Ehlers-Danlos syndrome but echocardiography was normal in all. Aortic dilation was common in classic Ehlers-Danlos syndrome but absent in hypermobile Ehlers-Danlos syndrome. Mitral valve prolapse and bicuspid aortic valve occurred at the same incidence as the general population. Cardiac symptoms were present in 12% but did not correlate with abnormal cardiac structure. Presentation with symptoms of musculoskeletal pain was inversely related to the presence of cardiac pathology. CONCLUSIONS: In light of the absence of cardiac pathology in patients with hypermobile Ehlers-Danlos syndrome, routine cardiac evaluation and echocardiography are not required for patients with hypermobile Ehlers-Danlos syndrome.


Assuntos
Ecocardiografia/estatística & dados numéricos , Síndrome de Ehlers-Danlos/diagnóstico , Cardiopatias/diagnóstico , Ventrículos do Coração/diagnóstico por imagem , Criança , Diagnóstico Diferencial , Síndrome de Ehlers-Danlos/complicações , Feminino , Cardiopatias/etiologia , Humanos , Masculino , Reprodutibilidade dos Testes , Estudos Retrospectivos
20.
World J Pediatr Congenit Heart Surg ; 10(3): 376-379, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-28673110

RESUMO

Aortic aneurysms requiring surgery in early childhood are rare. Herein we describe the case of a three-year-old with massive aneurysmal aortic dilation secondary to the rare and often lethal genetic disorder, cutis laxa. Initial thoracic aortic aneurysm gene panel was negative. Parents of the child were not known to be consanguineous, but high-density SNP array revealed several regions of homozygosity. This prompted targeted sequence analysis that identified a novel homozygous missense mutation in the gene for cutis laxa, EFEMP2. The patient underwent aortic valve-sparing aortic root and ascending aorta replacement and total aortic arch replacement, with continuous, moderately hypothermic cardiopulmonary bypass, using a dual cannulation technique. He was discharged well on the third postoperative day and remains free of aneurysmal disease at two-year follow-up.


Assuntos
Aorta/cirurgia , Aneurisma da Aorta Torácica/cirurgia , Valva Aórtica/cirurgia , Implante de Prótese Vascular/métodos , Cútis Laxa/complicações , Aorta/diagnóstico por imagem , Aneurisma da Aorta Torácica/diagnóstico , Aneurisma da Aorta Torácica/etiologia , Valva Aórtica/diagnóstico por imagem , Pré-Escolar , Angiografia por Tomografia Computadorizada , Ecocardiografia , Humanos , Imageamento Tridimensional , Masculino
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