Detalhe da pesquisa
1.
The Synthesis and Initial Evaluation of MerTK Targeted PET Agents.
Molecules
; 27(5)2022 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35268561
2.
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
J Am Chem Soc
; 141(39): 15700-15709, 2019 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31497954
3.
Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.
J Med Chem
; 67(7): 5866-5882, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38556760
4.
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
bioRxiv
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38562906
5.
SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells.
ACS Chem Biol
; 18(8): 1846-1853, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37556795
6.
SETDB1 Triple Tudor Domain Ligand, ( R,R )-59, Promotes Methylation of Akt1 in Cells.
bioRxiv
; 2023 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37214894
7.
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
J Med Chem
; 65(9): 6869-6887, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35467861
8.
Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology.
Alzheimers Dement (N Y)
; 8(1): e12253, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35434254
9.
AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery.
Alzheimers Dement (N Y)
; 8(1): e12246, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35475262
10.
UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Eur J Med Chem
; 220: 113534, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34038857
11.
MerTK activity is not necessary for the proliferation of glioblastoma stem cells.
Biochem Pharmacol
; 186: 114437, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33571503
12.
Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.
Eur J Med Chem
; 226: 113822, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34563964
13.
Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
J Med Chem
; 62(3): 1443-1454, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30624931
14.
Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors.
SLAS Discov
; 23(9): 982-988, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29842835
15.
Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group.
J Med Chem
; 61(22): 10242-10254, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30347155
16.
Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem
; 12(3): 207-213, 2017 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28032464
17.
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(22): 6439-42, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064063
18.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J Med Chem
; 49(12): 3520-35, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759095
19.
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
J Med Chem
; 49(12): 3563-80, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759099
20.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J Med Chem
; 49(21): 6416-20, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034148