1.
Bioorg Med Chem Lett
; 18(15): 4373-6, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18621524
RESUMO
Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke.