Detalhe da pesquisa
1.
Protocol for the Direct Conversion of Lactones to Lactams Mediated by 1,5,7-Triazabicyclo[4.4.0]dec-5-ene: Synthesis of Pyridopyrazine-1,6-diones.
J Org Chem
; 82(23): 12791-12797, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29049875
2.
Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Bioorg Med Chem Lett
; 25(4): 908-13, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582600
3.
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
J Med Chem
; 2024 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38848667
4.
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
Bioorg Med Chem Lett
; 22(8): 2906-11, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22429469
5.
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
J Pharmacol Exp Ther
; 338(1): 114-24, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21505060
6.
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Bioorg Med Chem Lett
; 19(10): 2865-9, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19386497
7.
Studies on the Bisoxazoline and (-)-Sparteine Mediated Enantioselective Addition of Organolithium Reagents to Imines.
Adv Synth Catal
; 350(7-8): 1023-1045, 2008 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19809587
8.
Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.
Bioorg Med Chem Lett
; 18(8): 2562-6, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18387300
9.
Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics.
Bioorg Med Chem Lett
; 18(23): 6293-7, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18951783
10.
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Medchemcomm
; 8(4): 730-743, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108792
11.
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
ACS Med Chem Lett
; 6(5): 596-601, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005540
12.
Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.
J Med Chem
; 57(3): 1046-62, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24428186
13.
O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors.
ACS Chem Neurosci
; 3(5): 418-26, 2012 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22860211
14.
Novel γ-secretase modulators: a review of patents from 2008 to 2010.
Expert Opin Ther Pat
; 21(2): 205-26, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21231889
15.
Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.
ACS Chem Neurosci
; 2(12): 705-710, 2011 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22229075
16.
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
ACS Med Chem Lett
; 2(2): 91-96, 2011 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21666860
17.
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Chem Biol
; 16(4): 411-20, 2009 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19389627
18.
Correlation of carboxylic acid pKa to protein binding and antibacterial activity of a novel class of bacterial translation inhibitors.
Bioorg Med Chem Lett
; 17(19): 5479-82, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17709248
19.
Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles.
Bioorg Med Chem Lett
; 17(8): 2347-50, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350254