Detalhe da pesquisa
1.
Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.
J Lipid Res
; 54(1): 177-88, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23103473
2.
Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.
J Lipid Res
; 53(1): 51-65, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22021650
3.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Bioorg Med Chem
; 20(9): 2845-9, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22494842
4.
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
J Exp Med
; 202(4): 517-27, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103409
5.
Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist.
J Pharmacol Exp Ther
; 336(2): 356-64, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21036912
6.
Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
Bioorg Med Chem Lett
; 21(10): 2911-5, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21493064
7.
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Bioorg Med Chem Lett
; 21(8): 2330-4, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21439820
8.
Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments.
Am J Physiol Endocrinol Metab
; 299(5): E816-24, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20807840
9.
Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.
Bioorg Med Chem Lett
; 20(12): 3750-4, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20483606
10.
Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.
Bioorg Med Chem Lett
; 20(4): 1448-52, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20096577
11.
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Bioorg Med Chem Lett
; 20(16): 4895-900, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20621473
12.
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Bioorg Med Chem Lett
; 20(22): 6524-32, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20933410
13.
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Bioorg Med Chem Lett
; 20(6): 1913-7, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20167483
14.
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Bioorg Med Chem Lett
; 20(7): 2106-10, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207541
15.
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Bioorg Med Chem Lett
; 20(15): 4399-405, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20598882
16.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 27(1): 32-40.e3, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31653597
17.
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.
Bioorg Med Chem Lett
; 19(9): 2591-4, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328684
18.
Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.
Eur J Pharmacol
; 579(1-3): 215-24, 2008 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18021763
19.
2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.
Bioorg Med Chem Lett
; 18(17): 4833-7, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18684621
20.
Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
Bioorg Med Chem Lett
; 18(15): 4393-6, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614364