Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
1.
J Biol Rhythms ; 38(5): 476-491, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37357746

RESUMO

Epidemiological studies associate night shift work with increased breast cancer risk. However, the underlying mechanisms are not clearly understood. To better understand these mechanisms, animal models that mimic the human situation of different aspects of shift work are needed. In this study, we used "timed sleep restriction" (TSR) cages to simulate clockwise and counterclockwise rotating shift work schedules and investigated predicted sleep patterns and mammary tumor development in breast tumor-prone female p53R270H©/+WAPCre mice. We show that TSR cages are effective in disturbing normal activity and estimated sleep patterns. Although circadian rhythms were not shifted, we observed effects of the rotating schedules on sleep timing and sleep duration. Sleep loss during a simulated shift was partly compensated after the shift and also partly during the free days. No effects were observed on body weight gain and latency time of breast cancer development. In summary, our study shows that the TSR cages can be used to model shift work in mice and affect patterns of activity and sleep. The effect of disturbing sleep patterns on carcinogenesis needs to be further investigated.


Assuntos
Neoplasias , Jornada de Trabalho em Turnos , Humanos , Camundongos , Feminino , Animais , Proteína Supressora de Tumor p53/genética , Ritmo Circadiano , Sono , Modelos Animais de Doenças , Tolerância ao Trabalho Programado
2.
Sci Rep ; 12(1): 2022, 2022 02 07.
Artigo em Inglês | MEDLINE | ID: mdl-35132155

RESUMO

Night shift work is associated with increased health risks. Here we examined the association of metabolic risk factors and immune cell counts, with both night shift work and particular characteristics thereof: frequency, duration and consecutive night shifts. We performed a cross-sectional study using data from 10,201 non-shift workers and 1062 night shift workers of the Lifelines Cohort study. Linear regression analyses, adjusted for demographic, lifestyle and occupational factors, were used to study associations of night shift work characteristics with metabolic risk factors and immune cell counts. Night shift workers had an increased BMI, waist circumference and immune cell counts compared to non-shift workers. This was especially seen in night shift workers who had a higher frequency of night shifts per month (≥ 5: BMI: B = 0.81 kg/m2 (95%-CI = 0.43-1.10); waist circumference: B = 1.58 cm (95%-Cl = 0.34-1.71; leukocytes: B = 0.19 × 109 cells/L (95%-CI = 0.04-0.34 × 109)) and worked more consecutive night shifts (> 3: BMI: B = 0.92 kg/m2 (95%-CI = 0.41-1.43); waist circumference: B = 1.85 cm (95%-Cl = 0.45-3.24); leukocytes: B = 0.32 × 109 cells/L (95%-CI = 0.09-0.55 × 109)). This association was less pronounced in long-term night shift workers (≥ 20 years). Our findings provide evidence for the association between night shift work characteristics and BMI, waist circumference and leukocytes (including, monocytes, lymphocytes, and basophil granulocytes).


Assuntos
Imunidade Celular , Contagem de Leucócitos , Saúde Ocupacional , Jornada de Trabalho em Turnos/efeitos adversos , Tolerância ao Trabalho Programado/fisiologia , Índice de Massa Corporal , Estudos de Coortes , Estudos Transversais , Fatores de Risco , Fatores de Tempo , Circunferência da Cintura
3.
Nutrients ; 13(12)2021 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-34960096

RESUMO

The term social jetlag is used to describe the discrepancy between biological time, determined by our internal body clock, and social times, mainly dictated by social obligations such as school or work. In industrialized countries, two-thirds of the studying/working population experiences social jetlag, often for several years. Described for the first time in 2006, a considerable effort has been put into understanding the effects of social jetlag on human physiopathology, yet our understanding of this phenomenon is still very limited. Due to its high prevalence, social jetlag is becoming a primary concern for public health. This review summarizes current knowledge regarding social jetlag, social jetlag associated behavior (e.g., unhealthy eating patterns) and related risks for human health.


Assuntos
Transtornos Cronobiológicos/fisiopatologia , Transtornos Cronobiológicos/psicologia , Ritmo Circadiano/fisiologia , Saúde , Transtornos Cronobiológicos/etiologia , Comportamento Alimentar , Feminino , Humanos , Conhecimento , Estilo de Vida , Masculino , Saúde Pública , Risco , Instituições Acadêmicas , Sono , Comportamento Social , Fatores de Tempo , Trabalho
4.
Chronobiol Int ; 36(5): 657-671, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30793958

RESUMO

Circadian rhythm disturbance (CRD) increases the risk of disease, e.g. metabolic syndrome, cardiovascular disease, and cancer. In the present study, we investigated later life adverse health effects triggered by repeated jet lag during gestation. Pregnant mice were subjected to a regular light-dark cycle (CTRL) or to a repeated delay (DEL) or advance (ADV) jet lag protocol. Both DEL and ADV offspring showed reduced weight gain. ADV offspring had an increased circadian period, and an altered response to a jet lag was observed in both DEL and ADV offspring. Analysis of the bones of adult male ADV offspring revealed reduced cortical bone mass and strength. Strikingly, analysis of the heart identified structural abnormalities and impaired heart function. Finally, DNA methylation analysis revealed hypermethylation of miR17-92 cluster and differential methylation within circadian clock genes, which correlated with altered gene expression. We show that developmental CRD affects the circadian system and predisposes to non-communicable disease in adult life.


Assuntos
Doenças Ósseas/etiologia , Ritmo Circadiano/fisiologia , Cardiopatias/etiologia , Síndrome do Jet Lag , Transtornos do Sono do Ritmo Circadiano/fisiopatologia , Animais , Relógios Circadianos/fisiologia , Modelos Animais de Doenças , Feminino , Genótipo , Síndrome do Jet Lag/fisiopatologia , Camundongos Endogâmicos C57BL , Fotoperíodo , Gravidez
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA