Detalhe da pesquisa
1.
Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
EMBO J
; 41(16): e110550, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35818993
2.
The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target.
Pharmacol Rev
; 74(4): 1051-1135, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36180112
3.
Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1-7) with selectivity for the C-terminal domain.
Bioorg Chem
; 129: 106204, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306699
4.
Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.
Pharmacol Rev
; 71(4): 539-570, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31537750
5.
ACE-domain selectivity extends beyond direct interacting residues at the active site.
Biochem J
; 477(7): 1241-1259, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32195541
6.
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV.
Clin Sci (Lond)
; 134(21): 2851-2871, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33146371
7.
Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).
Biochem J
; 476(10): 1553-1570, 2019 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31072910
8.
Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme.
Mol Pharmacol
; 93(4): 344-354, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29371233
9.
The effect of structural motifs on the ectodomain shedding of human angiotensin-converting enzyme.
Biochem Biophys Res Commun
; 481(1-2): 111-116, 2016 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27818199
10.
The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme.
J Chem Inf Model
; 56(12): 2486-2494, 2016 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27959521
11.
Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE).
J Biol Chem
; 289(3): 1798-814, 2014 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24297181
12.
Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence.
Biol Chem
; 395(10): 1135-49, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25205727
13.
Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.
Clin Sci (Lond)
; 127(1): 57-63, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24506807
14.
Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors.
Clin Sci (Lond)
; 126(4): 305-13, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24015848
15.
Structural insights into the inhibitory mechanism of angiotensin-I-converting enzyme by the lactotripeptides IPP and VPP.
FEBS Lett
; 598(2): 242-251, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37904282
16.
Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): opportunities for angiotensin-converting enzyme inhibitor design.
Clin Exp Pharmacol Physiol
; 40(8): 535-41, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23351021
17.
New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme.
Biol Chem
; 393(6): 485-93, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22628311
18.
Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides.
Biol Chem
; 393(12): 1547-54, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23667908
19.
Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide.
Biochem J
; 436(1): 53-9, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21352096
20.
Exploring the Impact of ACE Inhibition in Immunity and Disease.
J Renin Angiotensin Aldosterone Syst
; 2022: 9028969, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36016727